Search Results - "Tyndall, D."

Structural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14α-Demethylase by Sagatova, Alia A, Keniya, Mikhail V, Wilson, Rajni K, Monk, Brian C, Tyndall, Joel D A

“…Infections by fungal pathogens such as Candida albicans and Aspergillus fumigatus and their resistance to triazole drugs are major concerns. Fungal lanosterol…”
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Proteases and protease inhibitors in infectious diseases by Agbowuro, Ayodeji A., Huston, Wilhelmina M., Gamble, Allan B., Tyndall, Joel D. A.

“…There are numerous proteases of pathogenic organisms that are currently targeted for therapeutic intervention along with many that are seen as potential drug…”
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Crystal Structures of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provide Tools for Antifungal Discovery by Keniya, Mikhail V, Sabherwal, Manya, Wilson, Rajni K, Woods, Matthew A, Sagatova, Alia A, Tyndall, Joel D A, Monk, Brian C

“…Targeting lanosterol 14α-demethylase (LDM) with azole drugs provides prophylaxis and treatments for superficial and disseminated fungal infections, but cure…”
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Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer by Monk, Brian C., Tomasiak, Thomas M., Keniya, Mikhail V., Huschmann, Franziska U., Tyndall, Joel D. A., O'Connell, Joseph D., Cannon, Richard D., McDonald, Jeffrey G., Rodriguez, Andrew, Finer-Moore, Janet S., Stroud, Robert M.

“…Bitopic integral membrane proteins with a single transmembrane helix play diverse roles in catalysis, cell signaling, and morphogenesis. Complete monospanning…”
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Honey bee dopamine and octopamine receptors linked to intracellular calcium signaling have a close phylogenetic and pharmacological relationship by Beggs, Kyle T, Tyndall, Joel D A, Mercer, Alison R

“…Three dopamine receptor genes have been identified that are highly conserved among arthropod species. One of these genes, referred to in honey bees as Amdop2,…”
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Azole Resistance Reduces Susceptibility to the Tetrazole Antifungal VT-1161 by Monk, Brian C, Keniya, Mikhail V, Sabherwal, Manya, Wilson, Rajni K, Graham, Danyon O, Hassan, Harith F, Chen, Danni, Tyndall, Joel D A

“…Tetrazole antifungals designed to target fungal lanosterol 14α-demethylase (LDM) appear to be effective against a range of fungal pathogens. In addition, a…”
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Heterologous Expression of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provides Tools for Antifungal Discovery by Keniya, Mikhail V, Ruma, Yasmeen N, Tyndall, Joel D A, Monk, Brian C

“…Targeting lanosterol 14α-demethylase (LDM) with azole drugs provides prophylaxis and treatments for superficial and disseminated fungal infections, but cure…”
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Update 1 of: Proteases Universally Recognize Beta Strands In Their Active Sites by Madala, Praveen K, Tyndall, Joel D. A, Nall, Tessa, Fairlie, David P

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Anxiogenic and Stressor Effects of the Hypothalamic Neuropeptide RFRP-3 Are Overcome by the NPFFR Antagonist GJ14 by Kim, Joon S, Brownjohn, Phil W, Dyer, Blake S, Beltramo, Massimiliano, Walker, Christopher S, Hay, Debbie L, Painter, Gavin F, Tyndall, Joel D. A, Anderson, Greg M

“…RFamide-related peptide-3 (RFRP-3) is a recently discovered neuropeptide that has been proposed to play a role in the stress response. We aimed to elucidate…”
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Development of Covalent, Clickable Probes for Adenosine A1 and A3 Receptors by Trinh, Phuc N. H, Chong, Daniel J. W, Leach, Katie, Hill, Stephen J, Tyndall, Joel D. A, May, Lauren T, Vernall, Andrea J, Gregory, Karen J

“…Adenosine receptors are attractive therapeutic targets for multiple conditions, including ischemia-reperfusion injury and neuropathic pain. Adenosine receptor…”
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Sociodemographic factors, prescription history and opioid overdose deaths: a statewide analysis using linked PDMP and mortality data by Nechuta, Sarah J., Tyndall, Benjamin D., Mukhopadhyay, Sutapa, McPheeters, Melissa L.

“…•Large study of prescription history before overdose death by contributing drugs.•Sociodemographic risk factor profiles differed by type of opioid death.•>50%…”
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Structural and Functional Elucidation of Yeast Lanosterol 14α-Demethylase in Complex with Agrochemical Antifungals by Tyndall, Joel D A, Sabherwal, Manya, Sagatova, Alia A, Keniya, Mikhail V, Negroni, Jacopo, Wilson, Rajni K, Woods, Matthew A, Tietjen, Klaus, Monk, Brian C

“…Azole antifungals, known as demethylase inhibitors (DMIs), target sterol 14α-demethylase (CYP51) in the ergosterol biosynthetic pathway of fungal pathogens of…”
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Impact of Homologous Resistance Mutations from Pathogenic Yeast on Saccharomyces cerevisiae Lanosterol 14α-Demethylase by Sagatova, Alia A, Keniya, Mikhail V, Tyndall, Joel D A, Monk, Brian C

“…Fungal infections frequently affect immunodeficient individuals and are estimated to kill 1.35 million people per annum. Azole antifungals target the…”
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Proteases Universally Recognize Beta Strands In Their Active Sites by Tyndall, Joel D. A, Nall, Tessa, Fairlie, David P

“…Tyndall et al offer a comprehensive analysis in support of ligand conformation being important for recognition by all proteolytic enzymes and complements two…”
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Neutrophils suppress mucosal‐associated invariant T cells in humans by Schneider, Marion, Hannaway, Rachel F., Lamichhane, Rajesh, Harpe, Sara M., Tyndall, Joel D.A., Vernall, Andrea J., Kettle, Anthony J., Ussher, James E.

“…Mucosal‐associated invariant T (MAIT) cells are innate‐like T lymphocytes that are abundant in mucosal tissues and the liver where they can respond rapidly to…”
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Self-immolative Linkers in Prodrugs and Antibody Drug Conjugates in Cancer Treatment by Edupuganti, Veera V Shivaji R, Tyndall, Joel D A Tyndall D A, Gamble, Allan B

“…The design of anti-cancer therapies with high anti-tumour efficacy and reduced toxicity continues to be challenging. Anti-cancer prodrug and…”
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Abc1p Is a Multidrug Efflux Transporter That Tips the Balance in Favor of Innate Azole Resistance in Candida krusei by Lamping, Erwin, Ranchod, Amrita, Nakamura, Kenjirou, Tyndall, Joel D A, Niimi, Kyoko, Holmes, Ann R, Niimi, Masakazu, Cannon, Richard D

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Correlating cone beam CT results with temporomandibular joint pain of osteoarthritic origin by Palconet, G, Ludlow, J B, Tyndall, D A, Lim, P F

“…The purpose of this study was to determine whether bony changes in temporomandibular joint (TMJ) osteoarthritis (OA) is correlated with pain and other clinical…”
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Covalent cannabinoid receptor ligands - structural insight and selectivity challenges by Liddle, Ian, Glass, Michelle, Tyndall, Joel D. A, Vernall, Andrea J

“…X-ray crystallography and cryogenic electronic microscopy have provided significant advancement in the knowledge of GPCR structure and have allowed the…”
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A single point mutation converts a glutaryl-7-aminocephalosporanic acid acylase into an N-acyl-homoserine lactone acylase by Murugayah, Shereen A., Evans, Gary B., Tyndall, Joel D. A., Gerth, Monica L.

“…Objective To change the specificity of a glutaryl-7-aminocephalosporanic acid acylase (GCA) towards N -acyl homoserine lactones (AHLs; quorum sensing…”
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