Search Results - "Tynan, John A"

Clinical validation of a noninvasive prenatal test for genomewide detection of fetal copy number variants by Lefkowitz, Roy B., PhD, Tynan, John A., PhD, Liu, Tong, PhD, Wu, Yijin, PhD, Mazloom, Amin R., PhD, Almasri, Eyad, MS, Hogg, Grant, MS, Angkachatchai, Vach, PhD, Zhao, Chen, PhD, Grosu, Daniel S., MD, McLennan, Graham, MS, Ehrich, Mathias, MD

“…Background Current cell-free DNA assessment of fetal chromosomes does not analyze and report on all chromosomes. Hence, a significant proportion of fetal…”
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Noninvasive detection of fetal trisomy 21 by sequencing of DNA in maternal blood: a study in a clinical setting by Ehrich, Mathias, MD, Deciu, Cosmin, MSc, Zwiefelhofer, Tricia, Tynan, John A., DPhil, Cagasan, Lesley, MSc, Tim, Roger, DPhil, Lu, Vivian, McCullough, Ron, DPhil, McCarthy, Erin, Nygren, Anders O.H., DPhil, Dean, Jarrod, Tang, Lin, DPhil, Hutchison, Don, MSc, Lu, Tim, DPhil, Wang, Huiquan, DPhil, Angkachatchai, Vach, DPhil, Oeth, Paul, MSc, Cantor, Charles R., DPhil, Bombard, Allan, MD, van den Boom, Dirk, DPhil

“…Objective We sought to evaluate a multiplexed massively parallel shotgun sequencing assay for noninvasive trisomy 21 detection using circulating cell-free…”
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Multiplexed analysis of circulating cell-free fetal nucleic acids for noninvasive prenatal diagnostic RHD testing by Tynan, John A., DPhil, Angkachatchai, Vach, DPhil, Ehrich, Mathias, MD, Paladino, Toni, DPhil, van den Boom, Dirk, DPhil, Oeth, Paul, MS

“…Objective The objective of the study was the evaluation of a novel multiplex assay to detect fetal Rh blood group D-antigen gene ( RHD) loci in maternal plasma…”
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Horizons in Veterinary Precision Oncology: Fundamentals of Cancer Genomics and Applications of Liquid Biopsy for the Detection, Characterization, and Management of Cancer in Dogs by Chibuk, Jason, Flory, Andi, Kruglyak, Kristina M, Leibman, Nicole, Nahama, Alexis, Dharajiya, Nilesh, van den Boom, Dirk, Jensen, Taylor J, Friedman, Jeffrey S, Shen, M Richard, Clemente-Vicario, Francisco, Chorny, Ilya, Tynan, John A, Lytle, Katherine M, Holtvoigt, Lauren E, Murtaza, Muhammed, Diaz, Jr, Luis A, Tsui, Dana W Y, Grosu, Daniel S

“…Cancer is the leading cause of death in dogs, in part because many cases are identified at an advanced stage when clinical signs have developed, and prognosis…”
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Ets2 is required for trophoblast stem cell self-renewal by Wen, Fang, Tynan, John A., Cecena, Grace, Williams, Roy, Múnera, Jorge, Mavrothalassitis, George, Oshima, Robert G.

“…The Ets2 transcription factor is essential for the development of the mouse placenta and for generating signals for embryonic mesoderm and axis formation…”
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Proof-of-concept evaluation of next-generation sequencing-based liquid biopsy for non-invasive cancer detection in cats by Ruiz-Perez, Carlos A, Nakashe, Prachi, Marshall, Maggie A, Marass, Francesco, Tang, Tuong, McLennan, Lisa M, Kroll, Marissa, Flesner, Brian K, Gray, Suzanne, Rafalko, Jill M, Grosu, Daniel S, Hicks, Susan C, Tynan, John A, Tsui, Dana W Y, Flory, Andi, Kruglyak, Kristina M

“…This proof-of-concept evaluation demonstrates that next-generation sequencing-based liquid biopsy can detect genomic alterations in the blood of cats with…”
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Blood-Based Liquid Biopsy for Comprehensive Cancer Genomic Profiling Using Next-Generation Sequencing: An Emerging Paradigm for Non-invasive Cancer Detection and Management in Dogs by Kruglyak, Kristina M, Chibuk, Jason, McLennan, Lisa, Nakashe, Prachi, Hernandez, Gilberto E, Motalli-Pepio, Rita, Fath, Donna M, Tynan, John A, Holtvoigt, Lauren E, Chorny, Ilya, Grosu, Daniel S, Tsui, Dana W Y, Flory, Andi

“…This proof-of-concept study demonstrates that blood-based liquid biopsy using next generation sequencing of cell-free DNA can non-invasively detect multiple…”
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Detection of Age-Related Somatic Alterations in Canine Blood Using Next-Generation Sequencing-Based Liquid Biopsy: An Analysis of over 4800 Dogs by Kruglyak, Kristina M, O'Kell, Allison L, Cohen, Todd A, Marshall, Maggie A, Ruiz-Perez, Carlos A, Marass, Francesco, Tynan, John A, Hicks, Susan C, Lytle, Katherine M, Phelps-Dunn, Ashley, Brandstetter, Gina, Warren, Chelsea D, DiMarzio, Lauren R, Rosentel, Michelle C, Wong, Lilian K, McLennan, Lisa M, Rafalko, Jill M, Grosu, Daniel S, Chibuk, Jason, Chorny, Ilya, McCleary-Wheeler, Angela L, Flory, Andi, Tsui, Dana W Y

“…Age-related somatic genomic alterations in hematopoietic cell lines have been well characterized in humans; however, this phenomenon has not been well studied…”
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Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4 by HART, K. C, ROBERTSON, S. C, KANEMITSU, M. Y, MEYER, A. N, TYNAN, J. A, DONOGHUE, D. J

“…The fibroblast growth factor receptor (FGFR) family members mediate a number of important cellular processes, and are mutated or overexpressed in several forms…”
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Rotational coupling of the transmembrane and kinase domains of the Neu receptor tyrosine kinase by Bell, C A, Tynan, J A, Hart, K C, Meyer, A N, Robertson, S C, Donoghue, D J

“…Ligand binding to receptor tyrosine kinases (RTKs) regulates receptor dimerization and activation of the kinase domain. To examine the role of the…”
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Clinical validation of a blood-based liquid biopsy test integrating cell-free DNA quantification and next-generation sequencing for cancer screening in dogs by Flory, Andi, Ruiz-Perez, Carlos A, Clavere-Graciette, Ana G, Rafalko, Jill M, O'Kell, Allison L, Flesner, Brian K, McLennan, Lisa M, Hicks, Susan C, Nakashe, Prachi, Phelps-Dunn, Ashley, DiMarzio, Lauren R, Warren, Chelsea D, Cohen, Todd A, Chibuk, Jason, Chorny, Ilya, Grosu, Daniel S, Tsui, Dana W Y, Tynan, John A, Kruglyak, Kristina M

“…To validate the performance of a novel, integrated test for canine cancer screening that combines cell-free DNA quantification with next-generation sequencing…”
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Next-generation sequencing-based liquid biopsy may be used for detection of residual disease and cancer recurrence monitoring in dogs by McCleary-Wheeler, Angela L, Fiaux, Patrick C, Flesner, Brian K, Ruiz-Perez, Carlos A, McLennan, Lisa M, Tynan, John A, Hicks, Susan C, Rafalko, Jill M, Grosu, Daniel S, Chibuk, Jason, O'Kell, Allison L, Cohen, Todd A, Chorny, Ilya, Tsui, Dana W Y, Kruglyak, Kristina M, Flory, Andi

“…The purpose of this study was to evaluate the performance of a next-generation sequencing-based liquid biopsy test for cancer monitoring in dogs. Pre- and…”
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Clinical experience with next-generation sequencing-based liquid biopsy testing for cancer detection in dogs: a review of 1,500 consecutive clinical cases by O'Kell, Allison L, Lytle, Katherine M, Cohen, Todd A, Wong, Lilian K, Sandford, Emily, Rafalko, Jill M, Brandstetter, Gina, DiMarzio, Lauren R, Phelps-Dunn, Ashley, Rosentel, Michelle C, Warren, Chelsea D, McCleary-Wheeler, Angela L, Fiaux, Patrick C, Marass, Francesco, Marshall, Maggie A, Ruiz-Perez, Carlos A, Kruglyak, Kristina M, Tynan, John A, Hicks, Susan C, Grosu, Daniel S, Chibuk, Jason, Chorny, Ilya, Tsui, Dana W Y, Flory, Andi

“…To review ordering patterns, positivity rates, and outcome data for a subset of consecutive samples submitted for a commercially available, blood-based…”
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Ets2-Dependent Stromal Regulation of Mouse Mammary Tumors by Man, Albert K., Young, Lawrence J. T., Tynan, John A., Lesperance, Jacqueline, Egeblad, Mikala, Werb, Zena, Hauser, Craig A., Muller, William J., Cardiff, Robert D., Oshima, Robert G.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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RTK mutations and human syndromes: when good receptors turn bad by Robertson, Scott C, Tynan, John A, Donoghue, Daniel J

“…Mutations in receptor tyrosine kinases (RTKs) have been linked to an increasing number of inherited human disease syndromes, including dwarfism,…”
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Restriction Enzyme–Mediated Enhanced Detection of Circulating Cell-Free Fetal DNA in Maternal Plasma by Tynan, John A, Mahboubi, Payam, Cagasan, Lesley L, van den Boom, Dirk, Ehrich, Mathias, Oeth, Paul

“…A universal method confirming the presence of circulating cell-free fetal (ccff) DNA in maternal plasma is important in the field of noninvasive prenatal…”
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Multiplexed Analysis of Circulating Cell-Free Fetal Nucleic Acids for Noninvasive Prenatal Diagnostic RHD Testing by Tynan, John A, Angkachatchai, Vach, Ehrich, Mathias, Paladino, Toni, van den Boom, Dirk, Oeth, Paul

“…The fetuses of RhD-negative pregnant women that are positive for the Rh blood group D-antigen gene (RHD) are at risk for hemolytic disease of the fetus and…”
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Human Speedy: A Novel Cell Cycle Regulator That Enhances Proliferation through Activation of Cdk2 by Porter, Lisa A., Dellinger, Ryan W., Tynan, John A., Barnes, Elizabeth A., Kong, Monica, Lenormand, Jean-Luc, Donoghue, Daniel J.

“…The decision for a cell to self-replicate requires passage from G1 to S phase of the cell cycle and initiation of another round of DNA replication. This…”
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Noninvasive Detection of Fetal Trisomy 21 by Sequencing of DNA in Maternal Blood: A Study in a Clinical Setting by Ehrich, Mathias, Deciu, Cosmin, Zwiefelhofer, Tricia, Tynan, John A, Cagasan, Lesley, Tim, Roger, Lu, Vivian, McCullough, Ron, McCarthy, Erin, Nygren, Anders O. H, Dean, Jarrod, Tang, Lin, Hutchison, Don, Lu, Tim, Wang, Huiquan, Angkachatchai, Vach, Oeth, Paul, Cantor, Charles R, Bombard, Allan, van den Boom, Dirk

“…The incidence of trisomy 21 in the general population is about 1 in 800 births. The risk of this chromosomal aneuploidy increases with age to 1 in 35 term…”
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Ets2-dependent microenvironmental support of mouse mammary tumors by TYNAN, John A, FANG WEN, MULLER, William J, OSHIMA, Robert G

“…Decreasing the amount of active mouse Ets2 transcription factor by half in mice or use of a MAP kinase insensitive hypomorphic targeted Ets2 allele restricts…”
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