Search Results - "Tyms, A S"

Inhibition of HIV replication by amino-sugar derivatives by Fleet, George W.J., Karpas, Abraham, Dwek, Raymond A., Fellows, Linda E., Tyms, A.S., Petursson, Sigthor, Namgoong, Sung K., Ramsden, Nigel G., Smith, Paul W., Son, Jong Chan, Wilson, Francis, Witty, David R., Jacob, Gary S., Rademacher, Thomas W.

“…The plant alkaloids castanospermine, dihydroxymethyldihydroxypyrrolidine and deoxynojirimycin have recently been shown to have potential anti-HIV activity…”
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Inhibition of alpha-glucosidase I of the glycoprotein-processing enzymes by 6-O-butanoyl castanospermine (MDL 28,574) and its consequences in human immunodeficiency virus-infected T cells by TAYLOR, D. L, KANG, M. S, BRENNAN, T. M, BRIDGES, C. G, SUNKARA, P. S, TYMS, A. S

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Isolation and Characterization of the Fungal Metabolite 3-O-Methylviridicatin as an Inhibitor of Tumour Necrosis Factor α-Induced Human Immunodeficiency Virus Replication by Heguy, A, Cai, P, Meyn, P, Houck, D, Russo, S, Michitsch, R, Pearce, C, Katz, B, Bringmann, G, Feineis, D, Taylor, DL, Tyms, AS

“…The cytokine tumour necrosis factor α (TNF-α) has been shown to play a role in human immunodeficiency virus (HIV) replication by activating transcription of…”
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Pyrido [1,2a] indole derivatives identified as novel non-nucleoside reverse transcriptase inhibitors of human immunodeficiency virus type 1 by TAYLOR, D. L, AHMED, P. S, BOWLIN, T, CHAMBERS, P, TYMS, A. S, BEDARD, J, DUCHAINE, J, FALARDEAU, G, LAVALLEE, J. F, BROWN, W, RANDO, R. F

“…Pyrido [1,2a] indole derivatives were identified as potent inhibitors of human immunodeficiency virus type 1 (HIV-1) replication during a random screening…”
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Drug Resistance and Drug Combination Features of the Human Immunodeficiency Virus Inhibitor, BCH-10652 [(±)-2′-Deoxy-3′-Oxa-4′-Thiocytidine, dOTC] by Taylor, Debra L, Ahmed, Parvin S, Tyms, A Stanley, Wood, Lara J, Kelly, Lisa A, Chambers, Philip, Clarke, John, Bedard, Jean, Bowlin, Terry L, Rando, Robert F

“…The heterosubstituted nucleoside analogue dOTC [(±)-2′-deoxy-3′-oxa-4′-thiocytidine, BCH-10652] is a racemic compound structurally related to 3TC (lamivudine),…”
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MDL 74,968, a new acyclonucleotide analog: activity against human immunodeficiency virus in vitro and in the hu-PBL-SCID.beige mouse model of infection by Bridges, C G, Taylor, D L, Ahmed, P S, Brennan, T M, Hornsperger, J M, Navé, J F, Casara, P, Tyms, A S

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The ribonucleotide reductase inhibitor ( E)-2′-fluoromethylene-2′-deoxycytidine (MDL 101,731): a potential topical therapy for herpes simplex virus infection by Bridges, C.Gordon, Ahmed, S.Parvin, Sunkara, Prasad S., McCarthy, James R., Tyms, A.Stanley

“…The ribonucleotide reductase inhibitor MDL 101,731 was examined for antiviral activity against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro…”
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The prevention of cell adhesion and the cell-to-cell spread of HIV-1 in vitro by the alpha-glucosidase 1 inhibitor, 6-O-butanoyl castanospermine (MDL 28574) by Bridges, C G, Brennan, T M, Taylor, D L, McPherson, M, Tyms, A S

“…The intercellular adhesion molecule (ICAM-1, CD54) and its counter receptor, the integrin leukocyte function associated antigen 1 (LFA-1, CD11a/CD18), have…”
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Detection of human cytomegalovirus in peripheral mononuclear cells and urine samples using PCR by Stanier, P, Kitchen, A D, Taylor, D L, Tyms, A S

“…Samples of peripheral blood lymphocytes from 105 different blood donors were investigated for the presence of human cytomegalovirus (HCMV) DNA using the…”
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Potent inhibition of human immunodeficiency virus by MDL 101028, a novel sulphonic acid polymer by Taylor, D.L., Brennan, T.M., Bridges, C.G., Mullins, M.J., Tyms, A.S., Jackson, R., Cardin, A.D.

“…MDL 101028, a novel biphenyl disulphonic acid urea co-polymer was designed and synthesised as a heparin mimetic. This low molecular weight polymer showed…”
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Stilbene disulfonic acids. CD4 antagonists that block human immunodeficiency virus type-1 growth at multiple stages of the virus life cycle by CARDIN, A. D, SMITH, P. L, HYDE, L, BLANKENSHIP, D. T, BOWLIN, T. L, SCHROEDER, K, STAUDERMAN, K. A, TAYLOR, D. L, TYMS, A. S

“…The stilbene disulfonic acids 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS), 4,4'-diisothiocyanatodihydrostilbene-2,2'-disulfonic acid and,…”
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Inhibitors of polyamine biosynthesis block human cytomegalovirus replication by Tyms, A. S, Williamson, J. D

“…The antivirial activities of the few compounds available that are effective in the clinical treatment of virus infections are directed against nucleic acid…”
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Polyamine biosynthesis in cells infected with different clinical isolates of human cytomegalovirus by Clarke, J R, Tyms, A S

“…Previous work in this laboratory showed that polyamine biosynthesis was stimulated in fibroblasts following infection with the AD169 strain of human…”
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Loss of cytomegalovirus infectivity after treatment with castanospermine or related plant alkaloids correlates with aberrant glycoprotein synthesis by Taylor, D L, Fellows, L E, Farrar, G H, Nash, R J, Taylor-Robinson, D, Mobberley, M A, Ryder, T A, Jeffries, D J, Tyms, A S

“…Many plants contain polyhydroxyalkaloids which are potent inhibitors of glucosidases, enzymes involved in oligosaccharide trimming. These are important in…”
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Asymptomatic shedding and subsequent transmission of genital herpes simplex virus by Barton, S E, Davis, J M, Moss, V W, Tyms, A S, Munday, P E

“…We report the transmission of genital herpes simplex virus (HSV) infection from an asymptomatic woman shedding virus from the cervix to two male sexual…”
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Ultrastructural changes and immunocytochemical analysis of human placental trophoblast during short-term culture by Bax, C M, Ryder, T A, Mobberley, M A, Tyms, A S, Taylor, D L, Bloxam, D L

“…Trophoblastic cells, of at least 95 per cent purity by immunofluorescence and morphological criteria, were obtained from human term placenta by a simple…”
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The herpes simplex virus type 1 immediate-early protein ICP27 is obligately required for the accumulation of a cellular protein during viral infection by Estridge, J K, Kemp, L M, La Thangue, N B, Mann, B S, Tyms, A S, Latchman, D S

“…Lytic infection with herpes virus type 1 (HSV-1) causes the accumulation of a 40-kDa cellular protein (p40) which is also overexpressed in cultured cells…”
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Synthesis of Cytomegalovirus DNA Is an Antiviral Target Late in Virus Growth by Tyms, A. S, Davis, J. M, Clarke, J. R, Jeffries, D. J

“…Division of Virology, Department of Medical Microbiology, St Mary's Hospital Medical School, Paddington, London W2 1PG, U.K. The mechanism of action of…”
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Polyamine inhibitors in antimicrobial chemotherapy by Tyms, A S, Williamson, J D, Bacchi, C J

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Characterization of cytomegalovirus isolates from patients with AIDS by DNA restriction analysis by Taylor, D. L., Taylor-Robinson, D., Jeffries, D. J., Tyms, A. S.

“…Thirty-seven isolates of cytomegalovirus (CMV) were obtained from a group of 20 promiscuous homosexual men, either suffering from the acquired immunodeficiency…”
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