Search Results - "Tykocinski, L."

Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer by Greene, Mark I, Furuuchi, Keiji, Kojima, Yoshitsugu, Tone, Yukiko, Tone, Masahide, Tykocinski, Mark L

“…The transcription factor Foxp3 is involved in the differentiation, function and survival of CD4 + CD25 + regulatory T (T reg ) cells. Details of the mechanism…”
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Energy transfer in "parasitic" cancer metabolism: Mitochondria are the powerhouse and Achilles' heel of tumor cells by Martinez-Outschoorn, Ubaldo E., Pestell, Richard G., Howell, Anthony, Tykocinski, Mark L., Nagajyothi, Fnu, Machado, Fabiana S., Tanowitz, Herbert B., Sotgia, Federica, Lisanti, Michael P.

“…It is now widely recognized that the tumor microenvironment promotes cancer cell growth and metastasis via changes in cytokine secretion and extracellular…”
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Can Empathy, Other Personality Attributes, and Level of Positive Social Influence in Medical School Identify Potential Leaders in Medicine? by Hojat, Mohammadreza, Michalec, Barret, Veloski, J Jon, Tykocinski, Mark L

“…PURPOSETo test the hypotheses that medical students recognized by peers as the most positive social influencers would score (1) high on measures of engaging…”
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Fn14•TRAIL effectively inhibits hepatocellular carcinoma growth by Aronin, Alexandra, Amsili, Shira, Prigozhina, Tatyana B, Tzdaka, Kobi, Rachmilewitz, Jacob, Shani, Noam, Tykocinski, Mark L, Dranitzki Elhalel, Michal

“…New strategies for the treatment of hepatocellular carcinoma (HCC) are needed, given that currently available chemotherapeutics are inefficient. Since tumor…”
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Inhibition of effector function but not T cell activation and increase in FoxP3 expression in T cells differentiated in the presence of PP14 by Ochanuna, Zohar, Geiger-Maor, Anat, Dembinsky-Vaknin, Adi, Karussis, Dimitrios, Tykocinski, Mark L, Rachmilewitz, Jacob

“…T-helper polarization of naïve T cells is determined by a complex mechanism that involves many factors, eventually leading to activation of Th1, Th2, or Th17…”
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Virchow at 200 and Lown at 100 — Physicians as Activists by Mangione, Salvatore, Tykocinski, Mark L

“…The Covid-19 pandemic has forced many people to reconsider what medicine is all about. But debate over what doctoring is — and what it is not — is nothing new,…”
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Lipid length controls antigen entry into endosomal and nonendosomal pathways for CD1b presentation by Moody, D. Branch, Briken, Volker, Cheng, Tan-Yun, Roura-Mir, Carme, Guy, Mark R, Geho, David H, Tykocinski, Mark L, Besra, Gurdyal S, Porcelli, Steven A

“…CD1 proteins present various glycolipid antigens to T cells, but the cellular mechanisms that control which particular glycolipids generate T cell responses…”
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Fn14-TRAIL, a Chimeric Intercellular Signal Exchanger, Attenuates Experimental Autoimmune Encephalomyelitis by Razmara, Marjaneh, Hilliard, Brendan, Ziarani, Azadeh K, Murali, Ramachandran, Yellayi, Srikanth, Ghazanfar, Mustafa, Chen, Youhai H, Tykocinski, Mark L

“…Hallmarks of the pathogenesis of autoimmune encephalomyelitis include perivascular infiltration of inflammatory cells into the central nervous system,…”
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Negative Regulation of T Cell Activation by Placental Protein 14 Is Mediated by the Tyrosine Phosphatase Receptor CD45 by Rachmilewitz, Jacob, Borovsky, Zipora, Riely, Gregory J., Miller, Robin, Tykocinski, Mark L.

“…CD45 is the major protein tyrosine phosphatase receptor on T cell surfaces that functions as both a positive and a negative regulator of T cell receptor (TCR)…”
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Treatment and prevention of rat glioblastoma by immunogenic C6 cells expressing antisense insulin-like growth factor I RNA by TROJAN, J, JOHNSON, T. R, RUDIN, S. D, ILAN, J, TYKOCINSKI, M. L

“…Rat C6 glioma cells express insulin-like growth factor I (IGF-I) and form rapidly growing tumors in syngeneic animals. When transfected with an episome-based…”
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Academic Pathology's “Spiderless Network”: The power of a professional society, its listserv, and its journal during a public health emergency by Tykocinski, Mark L.

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Differential effects of chondroitin sulfates A and B on monocyte and B-cell activation: Evidence for B-cell activation via a CD44-dependent pathway by RACHMILEWITZ, J, TYKOCINSKI, M. L

“…At inflammatory sites, proteoglycans are both secreted by activated mononuclear leukocytes and released as a consequence of extracellular matrix degradation…”
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Differential Regulation of Th1/Th2 Cytokine Responses by Placental Protein 14 by Mishan-Eisenberg, Galit, Borovsky, Zipora, Weber, Matthew C, Gazit, Roi, Tykocinski, Mark L, Rachmilewitz, Jacob

“…The potency of TCR signaling during primary CD4+ T cell activation influences initial cytokine expression patterns and subsequent polarization toward either…”
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CTLA-4–Fas ligand functions as a trans signal converter protein in bridging antigen-presenting cells and T cells by Huang, Jui-Han, Tykocinski, Mark L.

“…Co-stimulator blockade and trans inhibitory signaling, using agents such as CTLA-4–Ig and Fas ligand (FasL) respectively have been invoked as alternative…”
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HuR Contributes to TRAIL Resistance by Restricting Death Receptor 4 Expression in Pancreatic Cancer Cells by Romeo, Carmella, Weber, Matthew C, Zarei, Mahsa, DeCicco, Danielle, Chand, Saswati N, Lobo, Angie D, Winter, Jordan M, Sawicki, Janet A, Sachs, Jonathan N, Meisner-Kober, Nicole, Yeo, Charles J, Vadigepalli, Rajanikanth, Tykocinski, Mark L, Brody, Jonathan R

“…Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal cancers, in part, due to resistance to both conventional and targeted therapeutics. TRAIL…”
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Cell-surface engineering with GPI-anchored proteins by Medof, M E, Nagarajan, S, Tykocinski, M L

“…Protein engineering of cell surfaces is a potentially powerful technology through which the surface protein composition of cells can be manipulated without…”
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Hierarchical Costimulator Thresholds for Distinct Immune Responses: Application of a Novel Two-Step Fc Fusion Protein Transfer Method by Chen, Aoshuang, Zheng, Guoxing, Tykocinski, Mark L

“…Activation of T cells is dependent upon coordinate engagement of Ag and costimulator receptors on their surfaces. In the case of the Ag receptors (TCRs),…”
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CTLA-4·Ig converts naive CD4+CD25− T cells into CD4+CD25+ regulatory T cells by Razmara, Marjaneh, Hilliard, Brendan, Ziarani, Azadeh K., Chen, Youhai H., Tykocinski, Mark L.

“…CTLA-4·Ig was originally designed as an immunosuppressive agent capable of interfering with the co-stimulation of T cells. In the present study, we demonstrate…”
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Pathology as the enabler of human research by CRAWFORD, James M, TYKOCINSKI, Mark L

“…Academic Pathology is a key player in human molecular science and in the powerful initiatives of the National Institutes of Health. Pathologists generate data…”
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Toxicology and Pharmacokinetic Studies in Mice and Nonhuman Primates of the Nontoxic, Efficient, Targeted Hexameric FasL: CTLA4-FasL by Makdasi, Efi, Amsili, Shira, Aronin, Alexandra, Prigozhina, Tatyana B, Tzdaka, Kobi, Gozlan, Yosi Meir, Ben Gigi-Tamir, Liat, Sagiv, Jitka Yehudith, Shkedy, Fanny, Shani, Noam, Tykocinski, Mark L, Dranitzki Elhalel, Michal

“…Cytotoxic T-lymphocyte antigen 4 (CTLA4)-FasL, a homo-hexameric signal converter protein, is capable of inducing robust apoptosis in malignant cells of the…”
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