Search Results - "Tye, Bik K"

MCM PROTEINS IN DNA REPLICATION by Tye, Bik K

“…The MCM proteins are essential replication initiation factors originally identified as proteins required for minichromosome maintenance in Saccharomyces…”
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Alternative Mechanisms for Coordinating Polymerase α and MCM Helicase by Lee, Chanmi, Liachko, Ivan, Bouten, Roxane, Kelman, Zvi, Tye, Bik K.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Mcm10 Mediates the Interaction Between DNA Replication and Silencing Machineries by Liachko, Ivan, Tye, Bik K

“…The connection between DNA replication and heterochromatic silencing in yeast has been a topic of investigation for >20 years. While early studies showed that…”
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Aneuploidy and improved growth are coincident but not causal in a yeast cancer model by Li, Xin Chenglin, Schimenti, John C, Tye, Bik K

“…Cancer cells have acquired mutations that alter their growth. Aneuploidy that typify cancer cells are often assumed to contribute to the abnormal growth…”
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Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis by Lei, M, Kawasaki, Y, Young, M R, Kihara, M, Sugino, A, Tye, B K

“…The initiation of DNA synthesis is an important cell cycle event that defines the beginning of S phase. This critical event involves the participation of…”
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Mcm10 and Cdc45 Cooperate in Origin Activation in Saccharomyces cerevisiae by Sawyer, Sara L, Cheng, Irene H, Chai, Weihang, Tye, Bik K

“…Mcm10 has recently been found to play a crucial role in multiple steps of the DNA replication initiation process in eukaryotes. Here, we have examined the role…”
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Genome-wide hierarchy of replication origin usage in Saccharomyces cerevisiae by Donato, Justin J, Chung, Shau Chee C, Tye, Bik K

“…Replication origins in a genome are inherently different in their base sequence and in their response to temporal and cell cycle regulation signals for DNA…”
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The Methanobacterium thermoautotrophicum MCM protein can form heptameric rings by Yu, Xiong, VanLoock, Margaret S, Poplawski, Andrzej, Kelman, Zvi, Xiang, Tao, Tye, Bik K, Egelman, Edward H

“…Mini‐chromosome maintenance (MCM) proteins form a conserved family found in all eukaryotes and are essential for DNA replication. They exist as…”
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Mcm10 is required for the maintenance of transcriptional silencing in Saccharomyces cerevisiae by Liachko, Ivan, Tye, Bik K

“…Mcm10 is an essential protein that participates in both the initiation and the elongation of DNA replication. In this study we demonstrate a role for Mcm10 in…”
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Insights into DNA Replication from the Third Domain of Life by Tye, B K

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Evidence for a Role of MCM (Mini-chromosome Maintenance)5 in Transcriptional Repression of Sub-telomeric and Ty-proximal Genes in Saccharomyces cerevisiae by Dziak, Renata, Leishman, David, Radovic, Maja, Tye, Bik K., Yankulov, Krassimir

“…The MCM (mini-chromosome maintenance) genes have a well established role in the initiation of DNA replication and in the elongation of replication forks in…”
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Computational detection of significant variation in binding affinity across two sets of sequences with application to the analysis of replication origins in yeast by Keich, Uri, Gao, Hong, Garretson, Jeffrey S, Bhaskar, Anand, Liachko, Ivan, Donato, Justin, Tye, Bik K

“…In analyzing the stability of DNA replication origins in Saccharomyces cerevisiae we faced the question whether one set of sequences is significantly enriched…”
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A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice by Shima, Naoko, Schimenti, John C, Alcaraz, Ana, Liachko, Ivan, Buske, Tavanna R, Andrews, Catherine A, Munroe, Robert J, Hartford, Suzanne A, Tye, Bik K

“…Mcm4 (minichromosome maintenance-deficient 4 homolog) encodes a subunit of the MCM2-7 complex (also known as MCM2-MCM7), the replication licensing factor and…”
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Mcm7, a Subunit of the Presumptive MCM Helicase, Modulates Its Own Expression in Conjunction with Mcm1 by Fitch, Michael J., Donato, Justin J., Tye, Bik K.

“…The Saccharomyces cerevisiae Mcm7 protein is a subunit of the presumed heteromeric MCM helicase that melts origin DNA and unwinds replication forks. Previous…”
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Mcm1 Promotes Replication Initiation by Binding Specific Elements at Replication Origins by Chang, Victoria K., Donato, Justin J., Chan, Clarence S., Tye, Bik K.

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Structural insights into the Cdt1-mediated MCM2-7 chromatin loading by Liu, Changdong, Wu, Rentian, Zhou, Bo, Wang, Jiafeng, Wei, Zhun, Tye, Bik K, Liang, Chun, Zhu, Guang

“…Initiation of DNA replication in eukaryotes is exquisitely regulated to ensure that DNA replication occurs exactly once in each cell division. A conserved and…”
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Ploidy dictates repair pathway choice under DNA replication stress by Li, Xin Chenglin, Tye, Bik K

“…This study reports an unusual ploidy-specific response to replication stress presented by a defective minichromosome maintenance (MCM) helicase allele in…”
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Initiating DNA synthesis: from recruiting to activating the MCM complex by Lei, M, Tye, B K

“…The exact duplication of a genome once per cell division is required of every proliferating cell. To achieve this goal, eukaryotes adopt a strategy that limits…”
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Dual functional regulators coordinate DNA replication and gene expression in proliferating cells by Tye, Bik K, Chang, Victoria K

“…Gene products for cell growth must meet the pace of DNA replication and vice versa during the cell division cycle, therefore coordination of DNA replication…”
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Mcm1 Binds Replication Origins by Chang, Victoria K, Fitch, Michael J, Donato, Justin J, Christensen, Tim W, Merchant, A Margaret, Tye, Bik K

“…Mcm1 is an essential protein required for the efficient replication of minichromosomes and the transcriptional regulation of early cell cycle genes in…”
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