Search Results - "Twyman, Roy"

Strengthening the Case for Epilepsy Drug Development: Bridging Experiences from the Alzheimer’s Disease Field—An Opinion by Twyman, Roy E.

“…Given the sheer number of drugs (over 20!) available for treatment of seizures, epilepsy can be considered one of the most successful areas in pharmaceutical…”
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New avenues for anti-epileptic drug discovery and development by Löscher, Wolfgang, Klitgaard, Henrik, Twyman, Roy E., Schmidt, Dieter

“…Key Points Despite the introduction of over 15 third-generation anti-epileptic drugs (AEDs) during the past three decades, current medications cannot control…”
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Identification of clinically relevant biomarkers of epileptogenesis — a strategic roadmap by Simonato, Michele, Agoston, Denes V., Brooks-Kayal, Amy, Dulla, Chris, Fureman, Brandy, Henshall, David C., Pitkänen, Asla, Theodore, William H., Twyman, Roy E., Kobeissy, Firas H., Wang, Kevin K., Whittemore, Vicky, Wilcox, Karen S.

“…Onset of many forms of epilepsy occurs after an initial epileptogenic insult or as a result of an identified genetic defect. Given that the precipitating…”
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Repurposed molecules for antiepileptogenesis: Missing an opportunity to prevent epilepsy? by Klein, Pavel, Friedman, Alon, Hameed, Mustafa Q., Kaminski, Rafal M., Bar‐Klein, Guy, Klitgaard, Henrik, Koepp, Mathias, Jozwiak, Sergiusz, Prince, David A., Rotenberg, Alexander, Twyman, Roy, Vezzani, Annamaria, Wong, Michael, Löscher, Wolfgang

“…Prevention of epilepsy is a great unmet need. Acute central nervous system (CNS) insults such as traumatic brain injury (TBI), cerebrovascular accidents (CVA),…”
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Revision of Unicompartmental Knee Arthroplasty Versus Primary Total Knee Arthroplasty by Craik, Johnathan D., MRCS, El Shafie, Sherif A., MRCS, Singh, Vinay K., FRCS orth, Twyman, Roy S., FRCS orth

“…Abstract The risk of revision following unicompartmental arthroplasty (UKA) is greater compared with primary total knee arthroplasty (TKA). Some surgeons…”
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Large-conductance calcium-activated potassium channel haploinsufficiency leads to sensory deficits in the visual system: a case report by Perche, Olivier, Lesne, Fabien, Patat, Alain, Raab, Susanne, Twyman, Roy, Ring, Robert H, Briault, Sylvain

“…Mutations in the genes encoding the large-conductance calcium-activated potassium channel, especially KCNMA1 encoding its α-subunit, have been linked to…”
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Electroretinography and contrast sensitivity, complementary translational biomarkers of sensory deficits in the visual system of individuals with fragile X syndrome by Perche, Olivier, Lesne, Fabien, Patat, Alain, Raab, Susanne, Twyman, Roy, Ring, Robert H, Briault, Sylvain

“…Abstract Background Disturbances in sensory function are an important clinical feature of neurodevelopmental disorders such as fragile X syndrome (FXS)…”
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Validation of revision data for total hip and knee replacements undertaken at a high volume orthopaedic centre against data held on the National Joint Registry by Afzal, Irrum, Radha, Sarkhell, Smoljanović, Tomislav, Stafford, Giles H, Twyman, Roy, Field, Richard E

“…With over 2.35 million records, the National Joint Registry (NJR) is the largest arthroplasty registry in the world. It provides a powerful tool to monitor…”
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Antiepileptogenesis and disease modification: Clinical and regulatory issues by French, Jacqueline A., Bebin, Martina, Dichter, Marc A., Engel, Jerome, Hartman, Adam L., Jóźwiak, Sergiusz, Klein, Pavel, McNamara, James, Twyman, Roy, Vespa, Paul

“…This is a summary report of clinical and regulatory issues discussed at the 2018 NINDS workshop, entitled “Accelerating Therapies for Antiepileptogenesis and…”
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Blinded prospective evaluation of computer-based mechanistic schizophrenia disease model for predicting drug response by Geerts, Hugo, Spiros, Athan, Roberts, Patrick, Twyman, Roy, Alphs, Larry, Grace, Anthony A

“…The tremendous advances in understanding the neurobiological circuits involved in schizophrenia have not translated into more effective treatments. An…”
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Antiepileptogenesis and disease modification: Progress, challenges, and the path forward—Report of the Preclinical Working Group of the 2018 NINDS‐sponsored antiepileptogenesis and disease modification workshop by Galanopoulou, Aristea S., Löscher, Wolfgang, Lubbers, Laura, O’Brien, Terence J., Staley, Kevin, Vezzani, Annamaria, D’Ambrosio, Raimondo, White, H. Steve, Sontheimer, Harald, Wolf, John A., Twyman, Roy, Whittemore, Vicky, Wilcox, Karen S., Klein, Brian

“…Epilepsy is one of the most common chronic brain diseases and is often associated with cognitive, behavioral, or other medical conditions. The need for…”
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Pharmacokinetic interactions of topiramate by BIALER, Meir, DOOSE, Dennis R, MURTHY, Bindu, CURTIN, Christopher, WANG, Shean-Sheng, TWYMAN, Roy E, SCHWABE, Stefan

“…Topiramate is a new antiepileptic drug (AED) that has been approved worldwide (in more than 80 countries) for the treatment of various kinds of epilepsy. It is…”
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Can local administration of tranexamic acid during total knee arthroplasty reduce blood loss and transfusion requirements in the absence of surgical drains? by Craik, Johnathan D., EI Shafie, Sherif A., Kidd, Alexander G., Twyman, Roy S.

“…Blood transfusions are frequently required following total knee arthroplasty. Tranexamic acid (TXA) inhibits fibrinolysis and has been shown to reduce blood…”
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The Caenorhabditis elegans unc-49 Locus Encodes Multiple Subunits of a Heteromultimeric GABA Receptor by Bamber, Bruce A, Beg, Asim A, Twyman, Roy E, Jorgensen, Erik M

“…Ionotropic GABA receptors generally require the products of three subunit genes. By contrast, the GABA receptor needed for locomotion in Caenorhabditis elegans…”
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Correlation analysis between anticonvulsant ED50 values of antiepileptic drugs in mice and rats and their therapeutic doses and plasma levels by Bialer, Meir, Twyman, Roy E, White, H Steve

“…Although there are several animal models of epilepsy, the extrapolation of antiepileptic drug (AEDs) performance to epileptic patients from anticonvulsant…”
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Glutamate receptor antibodies activate a subset of receptors and reveal an agonist binding site by Twyman, Roy E, Gahring, Lorise C, Spiess, Joachim, Rogers, Scott W

“…Two rabbits immunized with a portion of glutamate receptor (GIuR) subunit GIuR' (amino acids 245–457) exhibited seizure-like behaviors, suggesting that…”
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Pharmacological characterization of the homomeric and heteromeric UNC‐49 GABA receptors in C. elegans by Bamber, Bruce A, Twyman, Roy E, Jorgensen, Erik M

“…UNC‐49B and UNC‐49C are γ‐aminobutyric acid (GABA) receptor subunits encoded by the Caenorhabditis elegans unc‐49 gene. UNC‐49B forms a homomeric GABA…”
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Short-term outcome of unicompartmental knee arthroplasty in the octogenarian population by Tadros, Baha John, Dabis, John, Twyman, Roy

“…Purpose Unicompartmental knee arthroplasty (UKA) provides significant benefits to patients with anteromedial osteoarthritis, with good long-term results…”
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A case report: painful Hoffa’s fat pad herniation by Menzies-Wilson, Richard, Twyman, Roy

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Potent and selective pharmacodynamic synergy between the metabotropic glutamate receptor subtype 2–positive allosteric modulator JNJ‐46356479 and levetiracetam in the mouse 6‐Hz (44‐mA) model by Metcalf, Cameron S., Klein, Brian D., Smith, Misty D., Ceusters, Marc, Lavreysen, Hilde, Pype, Stefan, Van Osselaer, Nancy, Twyman, Roy, White, H. Steve

“…Summary Objective We previously demonstrated that positive allosteric modulators (PAMs) of metabotropic glutamate subtype 2 (mGlu2) receptors have potential…”
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