Search Results - "Twohig, Jason P."

DR3 Signaling Protects against Cisplatin Nephrotoxicity Mediated by Tumor Necrosis Factor by Al-Lamki, Rafia S, Lu, WanHua, Finlay, Sarah, Twohig, Jason P, Wang, Eddie C.Y, Tolkovsky, Aviva M, Bradley, John R

“…The expression of death receptor 3 (DR3), a member of the tumor necrosis factor (TNF) receptor superfamily, is up-regulated in human tubular epithelial cells…”
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ADAM17 targeting by human cytomegalovirus remodels the cell surface proteome to simultaneously regulate multiple immune pathways by Rubina, Anzelika, Patel, Mihil, Nightingale, Katie, Potts, Martin, Fielding, Ceri A, Kollnberger, Simon, Lau, Betty, Ladell, Kristin, Miners, Kelly L, Nichols, Jenna, Nobre, Luis, Roberts, Dawn, Trinca, Terrence M, Twohig, Jason P, Vlahava, Virginia-Maria, Davison, Andrew J, Price, David A, Tomasec, Peter, Wilkinson, Gavin W G, Weekes, Michael P, Stanton, Richard J, Wang, Eddie C Y

“…Human cytomegalovirus (HCMV) is a major human pathogen whose life-long persistence is enabled by its remarkable capacity to systematically subvert host immune…”
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Activation of naïve CD4+ T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4+ T cells by Twohig, Jason P., Cardus Figueras, Ana, Andrews, Robert, Wiede, Florian, Cossins, Benjamin C., Derrac Soria, Alicia, Lewis, Myles J., Townsend, Michael J., Millrine, David, Li, Jasmine, Hill, David G., Uceda Fernandez, Javier, Liu, Xiao, Szomolay, Barbara, Pepper, Christopher J., Taylor, Philip R., Pitzalis, Costantino, Tiganis, Tony, Williams, Nigel M., Jones, Gareth W., Jones, Simon A.

“…The cytokine IL-6 controls the survival, proliferation and effector characteristics of lymphocytes through activation of the transcription factors STAT1 and…”
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Death Receptor 3 Promotes Chemokine-Directed Leukocyte Recruitment in Acute Resolving Inflammation and Is Essential for Pathological Development of Mesothelial Fibrosis in Chronic Disease by Perks, William V, Singh, Ravinder K, Jones, Gareth W, Twohig, Jason P, Williams, Anwen S, Humphreys, Ian R, Taylor, Philip R, Jones, Simon A, Wang, Eddie C.Y

“…Death receptor 3 (DR3; TNFRSF25) and its tumor necrosis factor–like ligand TL1A (TNFSF15) control several processes in inflammatory diseases through the…”
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Regulation of Early Cartilage Destruction in Inflammatory Arthritis by Death Receptor 3 by Wang, Eddie C. Y., Newton, Zarabeth, Hayward, Olivia A., Clark, Stephen R., Collins, Fraser, Perks, William V., Singh, Ravinder K., Twohig, Jason P., Williams, Anwen S.

“…Objective To investigate the role of death receptor 3 (DR‐3) and its ligand tumor necrosis factor–like molecule 1A (TL1A) in the early stages of inflammatory…”
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The death receptor 3/TL1A pathway is essential for efficient development of antiviral CD4+ and CD8+ T‐cell immunity by Twohig, Jason P., Marsden, Morgan, Cuff, Simone M., Ferdinand, John R., Gallimore, Awen M., Perks, William V., Al‐Shamkhani, Aymen, Humphreys, Ian R., Wang, Eddie C. Y.

“…ABSTRACT Death receptor 3 (DR3, TNFRSF25), the closest family relative to tumor necrosis factor receptor 1, promotes CD4+ T‐cell‐driven inflammatory disease…”
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Toll-like receptor linked cytokine profiles in cerebrospinal fluid discriminate neurological infection from sterile inflammation by Cuff, Simone M, Merola, Joseph P, Twohig, Jason P, Eberl, Matthias, Gray, William P

“…Abstract Rapid determination of an infective aetiology causing neurological inflammation in the cerebrospinal fluid can be challenging in clinical practice…”
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Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation by Jones, Gareth W, Stumhofer, Jason S, Foster, Tom, Twohig, Jason P, Hertzog, Paul, Topley, Nicholas, Williams, Anwen S, Hunter, Christopher A, Jenkins, Brendan J, Wang, Eddie C.Y, Jones, Simon A

“…Tumor necrosis factor (TNF)-like cytokine (TL1A) is a T-cell costimulator that bolsters cytokine-induced activation through death receptor 3 (DR3). To explore…”
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The role of tumor necrosis factor receptor superfamily members in mammalian brain development, function and homeostasis by Twohig, Jason P, Cuff, Simone M, Yong, Audrey A, Wang, Eddie C Y

“…Tumor necrosis factor receptor superfamily (TNFRSF) members were initially identified as immunological mediators, and are still commonly perceived as…”
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Defective B cell ontogeny and humoral immune response in mice prematurely expressing human complement receptor 2 (CR2, CD21) is similar to that seen in aging wild type mice by Twohig, Jason P, Pappworth, Isabel Y, Sivasankar, Baalasubramanian, Kulik, Liudmila, Bull, Melanie, Holers, V Michael, Wang, Eddie C Y, Marchbank, Kevin J

“…Mice prematurely expressing human CR2 (hCR2) in the B cell lineage have a defective B cell ontogeny and humoral immune response. We have previously determined…”
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Activation of naive CD4.sup.+ T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4.sup.+ T cells by Twohig, Jason P, Cardus Figueras, Ana, Andrews, Robert, Wiede, Florian, Cossins, Benjamin C, Derrac Soria, Alicia, Lewis, Myles J

“…The cytokine IL-6 controls the survival, proliferation and effector characteristics of lymphocytes through activation of the transcription factors STAT1 and…”
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186 by Twohig, Jason P., Cardus, Anna, Jones, Gareth W., Jones, Simon A.

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186: CD4+ T-cell maturation and activation state dictate the impact of STAT3 mediated IL-6 induced changes in the transcriptome by Twohig, Jason P., Cardus, Anna, Jones, Gareth W., Jones, Simon A.

“…Interleukin-6 (IL-6) plays a pivotal role in essential inflammatory events in both innate and acquired immunity including T cell recruitment, differentiation,…”
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A functional role for death receptor-3 in arthritis by Williams, Anwen S., Bull, Melanie J., Mecklenburgh, Zarabeth, Calder, Claudia J., Twohig, Jason P., Elford, Carole, Evans, Bronwen, Al-Shamkhani, Aymen, Wang, Eddie

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