Search Results - "Twigger, K"

Characterization of the adaptive and innate immune response to intravenous oncolytic reovirus (Dearing type 3) during a phase I clinical trial by White, C L, Twigger, K R, Vidal, L, De Bono, J S, Coffey, M, Heinemann, L, Morgan, R, Merrick, A, Errington, F, Vile, R G, Melcher, A A, Pandha, H S, Harrington, K J

“…There is an emerging realization from animal models that the immune response may have both detrimental and beneficial therapeutic effects during cancer…”
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Inflammatory tumour cell killing by oncolytic reovirus for the treatment of melanoma by Errington, F, White, C L, Twigger, K R, Rose, A, Scott, K, Steele, L, Ilett, L J, Prestwich, R, Pandha, H S, Coffey, M, Selby, P, Vile, R, Harrington, K J, Melcher, A A

“…Reovirus is a promising unmodified double-stranded RNA (dsRNA) anti-cancer oncolytic virus, which is thought to specifically target cells with activated Ras…”
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Synergistic cytotoxicity of oncolytic reovirus in combination with cisplatin–paclitaxel doublet chemotherapy by Roulstone, V, Twigger, K, Zaidi, S, Pencavel, T, Kyula, J N, White, C, McLaughlin, M, Seth, R, Karapanagiotou, E M, Mansfield, D, Coffey, M, Nuovo, G, Vile, R G, Pandha, H S, Melcher, A A, Harrington, K J

“…Oncolytic reovirus is currently under active investigation in a range of tumour types. Early phase studies have shown that this agent has modest monotherapy…”
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9323 POSTER Enhanced in Vitro and in Vivo Cytotoxicity of Combined Vaccinia Virus Strain GLV-1h68 and Chemotherapy in Melanoma by Karapanaqiotou, E, Pencavel, T, Twigger, K, Mansfield, D, Roulstone, V, Syrigos, K, Harrington, K

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Escherichia coli nitroreductase plus CB1954 enhances the effect of radiotherapy in vitro and in vivo by White, C L, Menghistu, T, Twigger, K R, Searle, P F, Bhide, S A, Vile, R G, Melcher, A A, Pandha, H S, Harrington, K J

“…Escherichia coli nitroreductase (NTR) converts the prodrug CB1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide) into a bifunctional alkylating agent that causes DNA…”
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Reovirus and other oncolytic viruses for the targeted treatment of cancer by Vidal, L, Yap, T. A, White, C. L, Twigger, K, Hingorani, M, Agrawal, V, Kaye, S. B, Harrington, K. J, de Bono, J. S

“…In the last 50 years, there have been a number of anecdotal reports of viral infections causing transient cancer remissions in patients with advanced disease…”
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Phase I trial of intratumoral administration of reovirus type 3 with radiation in patients with advanced malignancies by Vidal-Boixader, L., Karavasilis, V., Beirne, D., Twigger, K., White, C., Pandha, H., Nutting, C., de Bono, J., Melcher, A., Harrington, K.

“…Abstract only 14009 Background: Reoviruses are RNA viruses that replicate preferentially in cells with aberrant Ras-pathway signaling. Preclinical data have…”
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