Search Results - "Twenhafel, Nancy A."

Effect of Monkeypox Virus Preparation on the Lethality of the Intravenous Cynomolgus Macaque Model by Mucker, Eric M, Shamblin, Josh D, Raymond, Jo Lynne, Twenhafel, Nancy A, Garry, Robert F, Hensley, Lisa E

“…For over two decades, researchers have sought to improve smallpox vaccines and also develop therapies to ensure protection against smallpox or smallpox-like…”
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Evaluation of Virulence in Cynomolgus Macaques Using a Virus Preparation Enriched for the Extracellular Form of Monkeypox Virus by Mucker, Eric M, Shamblin, Josh D, Goff, Arthur J, Bell, Todd M, Reed, Christopher, Twenhafel, Nancy A, Chapman, Jennifer, Mattix, Marc, Alves, Derron, Garry, Robert F, Hensley, Lisa E

“…The 2022 global human monkeypox outbreak emphasizes the importance of maintaining poxvirus research, including enriching a basic understanding of animal models…”
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Natural History of Aerosol-Induced Ebola Virus Disease in Rhesus Macaques by Downs, Isaac, Johnson, Joshua C, Rossi, Franco, Dyer, David, Saunders, David L, Twenhafel, Nancy A, Esham, Heather L, Pratt, William D, Trefry, John, Zumbrun, Elizabeth, Facemire, Paul R, Johnston, Sara C, Tompkins, Erin L, Jansen, Nathan K, Honko, Anna, Cardile, Anthony P

“…Ebola virus disease (EVD) is a serious global health concern because case fatality rates are approximately 50% due to recent widespread outbreaks in Africa…”
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Evaluation of Lassa antiviral compound ST-193 in a guinea pig model by Cashman, Kathleen A., Smith, Mark A., Twenhafel, Nancy A., Larson, Ryan A., Jones, Kevin F., Allen, Robert D., Dai, Dongcheng, Chinsangaram, Jarasvech, Bolken, Tove’ C., Hruby, Dennis E., Amberg, Sean M., Hensley, Lisa E., Guttieri, Mary C.

“…Lassa virus (LASV), a member of the Arenaviridae family, causes a viral hemorrhagic fever endemic to West Africa, where as many as 300,000 infections occur per…”
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Dose Response of MARV/Angola Infection in Cynomolgus Macaques following IM or Aerosol Exposure by Johnston, Sara C, Lin, Kenny L, Twenhafel, Nancy A, Raymond, Jo Lynne W, Shamblin, Joshua D, Wollen, Suzanne E, Wlazlowski, Carly B, Wilkinson, Eric R, Botto, Miriam A, Goff, Arthur J

“…Marburg virus infection in humans causes a hemorrhagic disease with a high case fatality rate. Countermeasure development requires the use of…”
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Anthrax Meningoencephalitis and Intracranial Hemorrhage by Caffes, Nicholas, Hendricks, Katherine, Bradley, John S, Twenhafel, Nancy A, Simard, J Marc

“…The neurological sequelae of Bacillus anthracis infection include a rapidly progressive fulminant meningoencephalitis frequently associated with intracranial…”
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Short-Course Postexposure Antibiotic Prophylaxis Combined with Vaccination Protects against Experimental Inhalational Anthrax by Vietri, Nicholas J., Purcell, Bret K., Lawler, James V., Leffel, Elizabeth K., Rico, Pedro, Gamble, Christopher S., Twenhafel, Nancy A., Ivins, Bruce E., Heine, Henry S., Sheeler, Ryan, Wright, Mary E., Friedlander, Arthur M.

“…Prevention of inhalational anthrax after Bacillus anthracis spore exposure requires a prolonged course of antibiotic prophylaxis. In response to the 2001…”
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A Short Course of Antibiotic Treatment Is Effective in Preventing Death from Experimental Inhalational Anthrax after Discontinuing Antibiotics by Vietri, Nicholas J., Purcell, Bret K., Tobery, Steven A., Rasmussen, Suzanne L., Leffel, Elizabeth K., Twenhafel, Nancy A., Ivins, Bruce E., Kellogg, Mark D., Webster, Wendy M., Wright, Mary E., Friedlander, Arthur M.

“…Background. Postexposure prophylaxis of inhalational anthrax requires prolonged antibiotic therapy or antibiotics and vaccination. The duration of treatment…”
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Niemann-pick C1 is essential for ebolavirus replication and pathogenesis in vivo by Herbert, Andrew S, Davidson, Cristin, Kuehne, Ana I, Bakken, Russell, Braigen, Stephen Z, Gunn, Kathryn E, Whelan, Sean P, Brummelkamp, Thijn R, Twenhafel, Nancy A, Chandran, Kartik, Walkley, Steven U, Dye, John M

“…Recent work demonstrated that the Niemann-Pick C1 (NPC1) protein is an essential entry receptor for filoviruses. While previous studies focused on filovirus…”
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Clindamycin Protects Nonhuman Primates Against Inhalational Anthrax But Does Not Enhance Reduction of Circulating Toxin Levels When Combined With Ciprofloxacin by Vietri, Nicholas J, Tobery, Steven A, Chabot, Donald J, Ingavale, Susham, Somerville, Brandon C, Miller, Jeremy A, Schellhase, Chris W, Twenhafel, Nancy A, Fetterer, David P, Cote, Christopher K, Klimko, Christopher P, Boyer, Anne E, Woolfitt, Adrian R, Barr, John R, Wright, Mary E, Friedlander, Arthur M

“…Abstract Background Inhalational anthrax is rare and clinical experience limited. Expert guidelines recommend treatment with combination antibiotics including…”
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Temporal Characterization of Marburg Virus Angola Infection following Aerosol Challenge in Rhesus Macaques by Lin, Kenny L, Twenhafel, Nancy A, Connor, John H, Cashman, Kathleen A, Shamblin, Joshua D, Donnelly, Ginger C, Esham, Heather L, Wlazlowski, Carly B, Johnson, Joshua C, Honko, Anna N, Botto, Miriam A, Yen, Judy, Hensley, Lisa E, Goff, Arthur J

“…Marburg virus (MARV) infection is a lethal hemorrhagic fever for which no licensed vaccines or therapeutics are available. Development of appropriate medical…”
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Natural History of Aerosol Exposure with Marburg Virus in Rhesus Macaques by Ewers, Evan C, Pratt, William D, Twenhafel, Nancy A, Shamblin, Joshua, Donnelly, Ginger, Esham, Heather, Wlazlowski, Carly, Johnson, Joshua C, Botto, Miriam, Hensley, Lisa E, Goff, Arthur J

“…Marburg virus causes severe and often lethal viral disease in humans, and there are currently no Food and Drug Administration (FDA) approved medical…”
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Rapid Real-Time PCR Assays for Detection of Klebsiella pneumoniae with the rmpA or magA Genes Associated with the Hypermucoviscosity Phenotype: Screening of Nonhuman Primates by Hartman, Laurie J, Selby, Edward B, Whitehouse, Chris A, Coyne, Susan R, Jaissle, James G, Twenhafel, Nancy A, Burke, Robin L, Kulesh, David A

“…The relationship of mucoviscosity-associated (magA) and/or regulator of mucoid phenotype (rmpA) genes to the Klebsiella pneumoniae hypermucoviscosity (HMV)…”
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Transient Lipopolysaccharide-Induced Resistance to Aerosolized Bacillus anthracis in New Zealand White Rabbits by Yee, Steven B, Dyer, David N, Twenhafel, Nancy A, Pitt, M Louise M

“…Previous studies have demonstrated that prior infection by various bacterial pathogens induces nonspecific resistance to subsequent infection by other…”
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Nosocomial infection of Serratia marcescens may induce a protective effect in monkeys exposed to Bacillus anthracis by Leffel, Elizabeth K, Twenhafel, Nancy A, Whitehouse, Chris A

“…Summary This study was originally designed to collect data on the natural history of inhalational anthrax in a new nonhuman primate model. An uncontrollable…”
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Alterations in Cytokines and Effects of Dexamethasone Immunosuppression during Subclinical Infections of Invasive Klebsiella pneumoniae with Hypermucoviscosity Phenotype in Rhesus (Macaca mulatta) and Cynomolgus (Macaca fascicularis) Macaques by Burke, Robin L, West, Michael W, Erwin-Cohen, Rebecca, Selby, Edward B, Fisher, Diana E, Twenhafel, Nancy A

“…Invasive Klebsiella pneumoniae with the hypermucoviscosity phenotype (HMV K. pneumoniae) is an emerging human pathogen that also has been attributed to fatal…”
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Corynebacterial necrohemorrhagic cystitis in two female macaques by Stevens, Edward L, Twenhafel, Nancy A, MacLarty, Anne M, Kreiselmeier, Norman

“…We describe severe necrohemorrhagic cystitis in a female rhesus macaque and a female cynomolgus macaque due to colonization of the urinary bladder by…”
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Rapid Real-Time PCR Assays for Detection of Klebsiella pneumoniae with the rmpA or magA Genes Associated with the Hypermucoviscosity Phenotype by Hartman, Laurie J, Selby, Edward B, Whitehouse, Chris A, Coyne, Susan R, Jaissle, James G, Twenhafel, Nancy A, Burke, Robin L, Kulesh, David A

“…The relationship of mucoviscosity-associated ( magA ) and/or regulator of mucoid phenotype ( rmpA ) genes to the Klebsiella pneumoniae hypermucoviscosity (HMV)…”
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Pathology of Inhalational Anthrax Animal Models by Twenhafel, N. A.

“…Anthrax is a lethal disease caused by the bacterium Bacillus anthracis. There are three principal forms of the disease in humans—cutaneous, gastrointestinal,…”
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Virulence of Burkholderia pseudomallei ATS2021 Unintentionally Imported to United States in Aromatherapy Spray by Cote, Christopher K, Mlynek, Kevin D, Klimko, Christopher P, Biryukov, Sergei S, Mou, Sherry, Hunter, Melissa, Rill, Nathaniel O, Dankmeyer, Jennifer L, Miller, Jeremey A, Talyansky, Yuli, Davies, Michael L, Meinig, J Matthew, Halasohoris, Stephanie A, Gray, Anette M, Spencer, Jade L, Babyak, Ashley L, Hourihan, M Kelly, Curry, Bobby J, Toothman, Ronald G, Ruiz, Sara I, Zeng, Xiankun, Ricks, Keersten M, Clements, Tamara L, Douglas, Christina E, Ravulapalli, Suma, Stefan, Christopher P, Shoemaker, Charles J, Elrod, Mindy G, Gee, Jay E, Weiner, Zachary P, Qiu, Ju, Bozue, Joel A, Twenhafel, Nancy A, DeShazer, David

“…In the United States in 2021, an outbreak of 4 cases of Burkholderia pseudomallei, the etiologic agent of melioidosis and a Tier One Select Agent (potential…”
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