Search Results - "Twelvetrees, Alison E"

Axonal Transport: Cargo-Specific Mechanisms of Motility and Regulation by Maday, Sandra, Twelvetrees, Alison E., Moughamian, Armen J., Holzbaur, Erika L.F.

“…Axonal transport is essential for neuronal function, and many neurodevelopmental and neurodegenerative diseases result from mutations in the axonal transport…”
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The Dynamic Localization of Cytoplasmic Dynein in Neurons Is Driven by Kinesin-1 by Twelvetrees, Alison E., Pernigo, Stefano, Sanger, Anneri, Guedes-Dias, Pedro, Schiavo, Giampietro, Steiner, Roberto A., Dodding, Mark P., Holzbaur, Erika L.F.

“…Cytoplasmic dynein, the major motor driving retrograde axonal transport, must be actively localized to axon terminals. This localization is critical as dynein…”
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The adaptor proteins HAP1a and GRIP1 collaborate to activate the kinesin-1 isoform KIF5C by Twelvetrees, Alison E, Lesept, Flavie, Holzbaur, Erika L F, Kittler, Josef T

“…Binding of motor proteins to cellular cargoes is regulated by adaptor proteins. HAP1 and GRIP1 are kinesin-1 adaptors that have been implicated individually in…”
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Neuronal activity mediated regulation of glutamate transporter GLT-1 surface diffusion in rat astrocytes in dissociated and slice cultures by Al Awabdh, Sana, Gupta-Agarwal, Swati, Sheehan, David F., Muir, James, Norkett, Rosalind, Twelvetrees, Alison E., Griffin, Lewis D., Kittler, Josef T.

“…The astrocytic GLT‐1 (or EAAT2) is the major glutamate transporter for clearing synaptic glutamate. While the diffusion dynamics of neurotransmitter receptors…”
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The lifecycle of the neuronal microtubule transport machinery by Twelvetrees, Alison E.

“…Neurons are incredibly reliant on their cytoskeletal transport machinery. During development the cytoskeleton is the primary driver of growth and remodelling…”
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Mending microtubules enhances cell polarity by Twelvetrees, Alison E.

“…Microtubule repair has recently emerged as a mechanism that is capable of enhancing the longevity of microtubules. In this issue of Developmental Cell,…”
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Methodological advances in imaging intravital axonal transport [version 1; peer review: 3 approved] by Sleigh, James N, Vagnoni, Alessio, Twelvetrees, Alison E, Schiavo, Giampietro

“…Axonal transport is the active process whereby neurons transport cargoes such as organelles and proteins anterogradely from the cell body to the axon terminal…”
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Intracellular Transport: New Tools Provide Insights into Multi-motor Transport by Hendricks, Adam G., Twelvetrees, Alison E., Holzbaur, Erika L.F.

“…Teams of kinesin and dynein motors drive bidirectional transport of intracellular cargoes along the microtubule cytoskeleton. How do opposite-polarity motors…”
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Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin by Twelvetrees, Alison E, Yuen, Eunice Y, Arancibia-Carcamo, I Lorena, MacAskill, Andrew F, Rostaing, Philippe, Lumb, Michael J, Humbert, Sandrine, Triller, Antoine, Saudou, Frederic, Yan, Zhen, Kittler, Josef T

“…The density of GABA(A) receptors (GABA(A)Rs) at synapses regulates brain excitability, and altered inhibition may contribute to Huntington's disease, which is…”
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Miro1 Is a Calcium Sensor for Glutamate Receptor-Dependent Localization of Mitochondria at Synapses by MacAskill, Andrew F., Rinholm, Johanne E., Twelvetrees, Alison E., Arancibia-Carcamo, I. Lorena, Muir, James, Fransson, Asa, Aspenstrom, Pontus, Attwell, David, Kittler, Josef T.

“…Energy use, mainly to reverse ion movements in neurons, is a fundamental constraint on brain information processing. Trafficking of mitochondria to locations…”
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Impaired α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) Receptor Trafficking and Function by Mutant Huntingtin by Mandal, Madhuchhanda, Wei, Jing, Zhong, Ping, Cheng, Jia, Duffney, Lara J., Liu, Wenhua, Yuen, Eunice Y., Twelvetrees, Alison E., Li, Shihua, Li, Xiao-Jiang, Kittler, Josef T., Yan, Zhen

“…Emerging evidence from studies of Huntington disease (HD) pathophysiology suggests that huntingtin (htt) and its associated protein HAP1 participate in…”
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Delivery of GABAARs to Synapses Is Mediated by HAP1-KIF5 and Disrupted by Mutant Huntingtin by Twelvetrees, Alison E., Yuen, Eunice Y., Arancibia-Carcamo, I. Lorena, MacAskill, Andrew F., Rostaing, Philippe, Lumb, Michael J., Humbert, Sandrine, Triller, Antoine, Saudou, Frederic, Yan, Zhen, Kittler, Josef T.

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Establishing a novel knock-in mouse line for studying neuronal cytoplasmic dynein under normal and pathologic conditions by Zhang, Jun, Twelvetrees, Alison E., Lazarus, Jacob E., Blasier, Kiev R., Yao, Xuanli, Inamdar, Nirja A., Holzbaur, Erika L. F., Pfister, K.Kevin, Xiang, Xin

“…Cytoplasmic dynein plays important roles in mitosis and the intracellular transport of organelles, proteins, and mRNAs. Dynein function is particularly…”
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Delivery of GABA sub(A)Rs to Synapses Is Mediated by HAP1-KIF5 and Disrupted by Mutant Huntingtin by Twelvetrees, Alison E, Yuen, Eunice Y, Arancibia-Carcamo, ILorena, MacAskill, Andrew F, Rostaing, Philippe, Lumb, Michael J, Humbert, Sandrine, Triller, Antoine, Saudou, Frederic, Yan, Zhen, Kittler, Josef T

“…The density of GABA sub(A) receptors (GABA sub(A)Rs) at synapses regulates brain excitability, and altered inhibition may contribute to Huntington's disease,…”
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Deslivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin by Twelvetrees, Alison E., Yuen, Eunice Y., Arancibia-Carcamo, I. Lorena, MacAskill, Andrew F., Rostaing, Philippe, Lumb, Michael J., Humbert, Sandrine, Triller, Antoine, Saudou, Frederic, Yan, Zhen, Kittler, Josef T.

“…The density of GABA A receptors (GABA A Rs) at synapses regulates brain excitability, and altered inhibition may contribute to Huntington’s disease, which is…”
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Delivery of GABA ARs to Synapses Is Mediated by HAP1-KIF5 and Disrupted by Mutant Huntingtin by Twelvetrees, Alison E., Yuen, Eunice Y., Arancibia-Carcamo, I. Lorena, MacAskill, Andrew F., Rostaing, Philippe, Lumb, Michael J., Humbert, Sandrine, Triller, Antoine, Saudou, Frederic, Yan, Zhen, Kittler, Josef T.

“…The density of GABA A receptors (GABA ARs) at synapses regulates brain excitability, and altered inhibition may contribute to Huntington's disease, which…”
Get full text