Search Results - "Tweedy, Clare"

Mitochondrial electron transport chain defects modify Parkinson's disease phenotypes in a Drosophila model by O'Hanlon, Maria E., Tweedy, Clare, Scialo, Filippo, Bass, Rosemary, Sanz, Alberto, Smulders-Srinivasan, Tora K.

“…INTRODUCTIONMitochondrial defects have been implicated in Parkinson's disease (PD) since complex I poisons were found to cause accelerated parkinsonism in…”
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Hippocampal network hyperexcitability in young transgenic mice expressing human mutant alpha-synuclein by Tweedy, Clare, Kindred, Nathan, Curry, Joshua, Williams, Christopher, Taylor, John-Paul, Atkinson, Peter, Randall, Fiona, Erskine, Daniel, Morris, Christopheer M., Reeve, Amy K., Clowry, Gavin J., LeBeau, Fiona E.N.

“…Abnormal excitability in cortical networks has been reported in patients and animal models of Alzheimer's disease (AD), and other neurodegenerative conditions…”
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Impaired Fast Network Oscillations and Mitochondrial Dysfunction in a Mouse Model of Alpha-synucleinopathy (A30P) by Robson, Emma, Tweedy, Clare, Manzanza, Nelson, Taylor, John-Paul, Atkinson, Peter, Randall, Fiona, Reeve, Amy, Clowry, Gavin J., LeBeau, Fiona E.N.

“…•Age-dependent impairment in hippocampal gamma frequency activity in A30P mice.•Gamma oscillations in slices from A30P mice show greater sensitivity to…”
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Protective effect of PDE4B subtype-specific inhibition in an App knock-in mouse model for Alzheimer's disease by Armstrong, Paul, Güngör, Hüseyin, Anongjanya, Pariya, Tweedy, Clare, Parkin, Edward, Johnston, Jamie, Carr, Ian M, Dawson, Neil, Clapcote, Steven J

“…Meta-analysis of genome-wide association study data has implicated PDE4B in the pathogenesis of Alzheimer's disease (AD), the leading cause of senile dementia…”
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Anti‐inflammatory treatment rescues memory deficits during aging in nfkb1−/− mice by Fielder, Edward, Tweedy, Clare, Wilson, Caroline, Oakley, Fiona, LeBeau, Fiona E. N., Passos, João F., Mann, Derek A., Zglinicki, Thomas, Jurk, Diana

“…Chronic inflammation is a common feature of many age‐related conditions including neurodegenerative diseases such as Alzheimer's disease. Cellular senescence…”
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Age-dependent hippocampal network dysfuntion in a mouse model of alpha-synucleinopathy by Tweedy, Clare

“…Aggregation of the protein alpha-synuclein (ASYN) is a key pathological feature of the alpha-synucleinopathies, a group of diseases including Lewy body…”
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