Search Results - "Tweats, D J"

Report of the IWGT working group on strategies and interpretation of regulatory in vivo tests I. Increases in micronucleated bone marrow cells in rodents that do not indicate genotoxic hazards by TWEATS, D. J, BLAKEY, D, TICE, R, HEFLICH, R. H, JACOBS, A, JACOBSEN, S. D, MORITA, T, NOHMI, T, O'DONOVAN, M. R, SASAKI, Y. F, SOFUNI, T

“…In vivo genotoxicity tests play a pivotal role in genotoxicity testing batteries. They are used both to determine if potential genotoxicity observed in vitro…”
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Testing strategies in mutagenicity and genetic toxicology: An appraisal of the guidelines of the European Scientific Committee for Cosmetics and Non-Food Products for the evaluation of hair dyes by Kirkland, D.J., Henderson, L., Marzin, D., Müller, L., Parry, J.M., Speit, G., Tweats, D.J., Williams, G.M.

“…The European Scientific Committee on Cosmetics and Non-Food Products (SCCNFP) guideline for testing of hair dyes for genotoxic/mutagenic/carcinogenic potential…”
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Report of the IWGT working group on strategy/interpretation for regulatory in vivo tests II. Identification of in vivo-only positive compounds in the bone marrow micronucleus test by TWEATS, D. J, BLAKEY, D, TICE, R, HEFLICH, R. H, JACOBS, A, JACOBSEN, S. D, MORITA, T, NOHMI, T, O'DONOVAN, M. R, SASAKI, Y. F, SOFUNI, T

“…A survey conducted as part of an International Workshop on Genotoxicity Testing (IWGT) has identified a number of compounds that appear to be more readily…”
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The GreenScreen® genotoxicity assay: a screening validation programme by Cahill, P.A., Knight, A.W., Billinton, N., Barker, M.G., Walsh, L., Keenan, P.O., Williams, C.V., Tweats, D.J., Walmsley, R.M.

“…A yeast (Saccharomyces cerevisiae) DNA repair reporter assay termed the GreenScreen® assay (GSA) is described. This is a novel, cost‐effective genotoxicity…”
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An assessment of the utility of the yeast GreenScreen assay in pharmaceutical screening by Van Gompel, J., Woestenborghs, F., Beerens, D., Mackie, C., Cahill, P.A., Knight, A.W., Billinton, N., Tweats, D.J., Walmsley, R.M.

“…In this paper we describe an initial reproducibility study of 12 proprietary compounds followed by the assessment of 51 marketed pharmaceuticals and, lastly, a…”
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An analysis of results from 305 compounds tested with the yeast RAD54-GFP genotoxicity assay (GreenScreen GC)—including relative predictivity of regulatory tests and rodent carcinogenesis and performance with autofluorescent and coloured compounds by Knight, Andrew W., Billinton, N., Cahill, P. A., Scott, A., Harvey, J. S., Roberts, K. J., Tweats, D. J., Keenan, P. O., Walmsley, R. M.

“…Data from 305 non-proprietary compounds tested using the yeast RAD54-GFP (Green Fluorescent Protein) assay, GreenScreen GC, are presented, together with a…”
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Determination of genetic toxicity and potential carcinogenicity in vitro—challenges post the Seventh Amendment to the European Cosmetics Directive by Tweats, D.J., Scott, A.D., Westmoreland, C., Carmichael, P.L.

“…Genetic toxicology and its role in the detection of carcinogens is currently undergoing a period of reappraisal. There is an increasing interest in developing…”
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The preclinical toxicological evaluation of sumatriptan by Owen, K, Hartley, K, Tucker, M L, Parkinson, M M, Tweats, D J, Jackson, M R

“…1 Sumatriptan is a potent and selective 5-HT1 receptor agonist marketed for the treatment of migraine by both oral and subcutaneous routes. An extensive…”
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Investigations into the induction of aneuploidy and polyploidy in mammalian cells by the anti-tussive agent noscapine hydrochloride by Gatehouse, D G, Stemp, G, Pascoe, S, Wilcox, P, Hawker, J, Tweats, D J

“…Noscapine, a non-narcotic, centrally-acting anti-tussive drug induces polyploidy in Chinese hamster CHL cells; further studies were carried out to investigate…”
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Uptake of tritiated thymidine by cells of the rat gastric mucosa after exposure to loxtidine or omeprazole by Burlinson, B, Morriss, S, Gatehouse, D G, Tweats, D J, Jackson, M R

“…The H2-antagonist loxtidine and the H+/K(+)-ATPase inhibitor omeprazole inhibit gastric acid secretion and both have been associated with the appearance of…”
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Genotoxicity studies of gastric acid inhibiting drugs by Burlinson, B, Morriss, S H, Gatehouse, D G, Tweats, D J

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Further debate of testing strategies by Tweats, D J, Gatehouse, D G

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Studies of error-prone DNA repair in Escherichia coli K-12 and Ames Salmonella typhimurium strains using a model alkylating agent by Little, C A, Tweats, D J, Pinney, R J

“…4-Acetoxy-3-acetoxymethyl acetophenone (AAMAP) is mutagenic in Ames Salmonella typhimurium tester strains TA100 and TA98, which carry plasmid pKM101, but not…”
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Relevance of plasmid pKM101-mediated mutagenicity in bacteria to genotoxicity in mammalian cells by Little, C A, Tweats, D J, Pinney, R J

“…Three structurally related compounds, 4-acetoxy-3-acetoxy-methyl-acetophenone (AAMAP), 1-[4'-hydroxy-3'-hydroxy-methylphenyl]-2-[benzyl-t-butylamino] ethanone…”
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Investigations into the genotoxic potential of loxtidine, a long-acting H2-receptor antagonist by Gatehouse, D, Wedd, D J, Paes, D, Delow, G, Burlinson, B, Pascoe, S, Brice, A, Stemp, G, Tweats, D J

“…Loxtidine, a potent, non-competitive histamine H2-receptor antagonist was evaluated for genotoxic potential using a range of short-term mutagenicity assays…”
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Monitoring the marine environment for mutagens by PARRY, J. M, TWEATS, D. J, AL-MOSSAWI, M. A. J

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A differential killing assay for mutagens and carcinogens based on an improved repair-deficient strain of Escherichia coli by Tweats, D J, Green, M H, Muriel, W J

“…The lexA gene suppresses the spontaneous inviability of recA strains of Escherichia coli without affecting their repair deficiency. We have taken advantage of…”
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R-Factor-Mediated Nuclease Activity Involved in Thymineless Elimination by Tweats, D J, Pinney, R J, Smith, J T

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Plasmid pGW16, a derivative of pKM101, increases post-UV DNA synthesis, but sensitises some strains of Escherichia coli to UV by Little, C A, Tweats, D J, Pinney, R J

“…Plasmid pKM101, which carries muc genes that are analogous in function to chromosomal umu genes, protected Escherichia coli strains AB1157 uvrB+ umuC+, JC3890…”
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Ondansetron: pre-clinical safety evaluation by Tucker, M L, Jackson, M R, Scales, M D, Spurling, N W, Tweats, D J, Capel-Edwards, K

“…A programme of pre-clinical safety evaluation of ondansetron has been undertaken which involved a series of studies - single dose studies, repeat dose studies,…”
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