Search Results - "Tutwiler, Gene F"

Stereoselective synthesis and biological activity of .beta.- and .alpha.-D-arabinose 1,5-diphosphate: analogs of a potent metabolic regulator by Maryanoff, Bruce E, Reitz, Allen B, Tutwiler, Gene F, Benkovic, Stephen J, Benkovic, Patricia A, Pilkis, Simon J

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Resolution of (.+-.)-2-tetradecyloxiranecarboxylic acid. Absolute configuration and chiral synthesis of the hypoglycemic R enantiomer and biological activity of enantiomers by Ho, Winston, Tarhan, Okan, Kiorpes, Timothy C, Tutwiler, Gene F, Mohrbacher, Richard J

“…The resolution of the hypoglycemic agent (+/-)-2-tetradecyloxiranecarboxylic acid (3) as its d- and l-ephedrine salts is presented. The active enantiomer…”
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Alkylglycidic acids: potential new hypoglycemic agents by Ho, Winston, Tutwiler, Gene F, Cottrell, Sandra C, Morgans, Dave J, Tarhan, Okan, Mohrbacher, Richard J

“…A series of alkylglycidic acid analogues and derivatives were synthesized and tested for their ability to inhibit long-chain fatty acid oxidation in vitro and…”
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A pharmacologic profile of McN-3495 [N-(1-methyl-2-pyrrolidinylidene)-N'-phenyl-1-pyrrolidinecarboximidamide], a new, orally effective hypoglycemic agent by Tutwiler, G F, Kirsch, T, Bridi, G

“…McN-3495, a new compound unrelated strucuturally to the sulfonylureas or phenformin, has been found to produce a hypoglycemic effect in nondiabetic rats, dogs,…”
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Methyl 2-tetradecylglycidate, an orally effective hypoglycemic agent that inhibits long chain fatty acid oxidation selectively by Tutwiler, G F, Mohrbacher, R, Ho, W

“…The oral hypoglycemic agents methyl 2-tetradecylglycidate (McN-3716) and 2-tetradecylglycidic acid (McN-3802), synthesized in an effort to design a specific…”
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Inhibition of mitochondrial carnitine palmitoyl transferase by 2-tetradecylglycidic acid (McN-3802) (preliminary communication) by Tutwiler, G F, Ryzlak, M T

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Relation of Oxidation of Long‐Chain Fatty Acids to Gluconeogenesis in the Perfused Liver of the Guinea Pig by TUTWILER, Gene F., BRENTZEL, H. James

“…1 The potent, specific inhibitor of long‐chain fatty acid oxidation, 2‐tetradecylglycitiic acid (McN‐3802), at 10μM totally abolished ketogenesis from…”
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Pharmacologic profile of methyl 2-tetradecylglycidate (McN-3716)--an orally effective hypoglycemic agent by Tutwiler, G F, Kirsch, T, Mohrbacher, R J, Ho, W

“…A specific inhibitor of fatty acid oxidation, methyl 2-tetradecylglycidate (McN-3716) has been found to produce a dose dependent hypoglycemic effect when…”
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Hypoglycaemic and hypoketonaemic effects of single and repeated oral doses of methyl palmoxirate (methyl 2‐tetradecylglycidate) in streptozotocin/alloxan‐induced diabetic dogs by Tuman, Robert W., Tutwiler, Gene F., Joseph, John M., Wallace, Nathaniel H.

“…1 The hypoglycaemic and hypoketonaemic effects of orally administered methyl palmoxirate were studied in streptozotocin/alloxan‐induced diabetic dogs. 2 Single…”
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Effect of methyl palmoxirate, an oral hypoglycemic agent, on epinephrine-induced hyperglycemia in the rat by Tutwiler, G F, Joseph, J, Wallace, N

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Highly purified human growth hormone fails to stimulate lipolysis in rabbit adipocytes in vitro or in rabbits in vivo by Bowden, C R, White, K D, Lewis, U J, Tutwiler, G F

“…To determine whether the rapid lipolytic effect observed with human growth hormone (hGH) preparations in rabbits and rabbit adipose tissue is an intrinsic…”
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Influence of the oral hypoglycemic agent linogliride (McN-3935) on insulin secretion from isolated rat islets of Langerhans by Zawalich, W S, Rasmussen, G, Tuman, R W, Tutwiler, G F

“…The influence of a new orally effective hypoglycemic compound, linogliride (McN-3935), on insulin release from isolated perifused rat islets was investigated…”
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Immunological characterization of a diabetogenic protein from bovine adenohypophysis by Tutwiler, G F

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Immunological cross-reaction of bovine growth hormone (NIH-GH-B8) with the antiserum to the bovine diabetogenic protein by Tutwiler, G F

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Comparison of McN-3495 [N-(1-methyl-2-pyrrolidinylidene)-N'-phenyl-1-pyrrolidinecarboximidamide], a new, orally effective, hypoglycemic agent, with the biguanides by Tutwiler, G F, Bridi, G

“…McN-3495 [chemical name: N-(1-methyl-2-pyrrolidinylidene)-N'-phenyl-1-pyrrolidinecarboximidamide], a new, oral, effective hypoglycemic agent that is…”
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Diabetogenic activity of the anterior pituitary (a progress report) by Tutwiler, G F

“…The exact nature of the diabetogenic activity of the anterior pituitary gland remains a mystery. While growth hormone (GH) fractions clearly can produce a…”
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Relation of oxidation of long-chain fatty acids to gluconeogenesis in the perfused liver of the guinea pig: effect of 2-tetradecylglycidic acid (McN-3802) by Tutwiler, G F, Brentzel, H J

“…1. The potent, specific inhibitor of long-chain fatty acid oxidation, 2-tetradecylglycidic acid (McN-3802), at 10 microM totally abolished ketogenesis from…”
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Effect of the oral hypoglycemic agent, pirogliride, on gluconeogenesis by Tutwiler, G F, Brentzel, H J

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Effect of the oral hypoglycemic agent, pirogliride, on lipolysis by Tutwiler, G F

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Effect of the fatty acid oxidation inhibitor 2-tetradecylglycidic acid (TDGA) on glucose and fatty acid oxidation in isolated rat soleus muscle by Tuman, R W, Joseph, J M, Brentzel, H J, Tutwiler, G F

“…1. The effect of 2-tetradecylglycidic acid (TDGA), a potent, specific inhibitor of long-chain fatty acid oxidation, on fatty acid and glucose oxidation by…”
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