Search Results - "Tutton, Stephen"

CTCF driven TERRA transcription facilitates completion of telomere DNA replication by Beishline, Kate, Vladimirova, Olga, Tutton, Stephen, Wang, Zhuo, Deng, Zhong, Lieberman, Paul M.

“…Telomere repeat DNA forms a nucleo-protein structure that can obstruct chromosomal DNA replication, especially under conditions of replication stress…”
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A role for p53 in telomere protection by Tutton, Stephen, Lieberman, Paul M.

“…Telomeres cap the ends of chromosomes and are crucial for genome stability. The p53 protein (TP53) is a vital tumor suppressor, activating the transcription of…”
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Specific Double-Stranded RNA Interference in Undifferentiated Mouse Embryonic Stem Cells by Yang, Shicheng, Tutton, Stephen, Pierce, Eric, Yoon, Kyonggeun

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The Sensor IRE1 Couples Stress Detection to Protein Synthesis by Ricci, Daniela, Saunders, Jillian, Tutton, Stephen, Gidalevitz, Tali, Argon, Yair

“…Endoplasmic reticulum (ER) stress results in accumulation of misfolded proteins and profoundly regulates cellular protein synthesis. The regulation includes…”
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The Basis for kcat Impairment in Prophospholipase A2 from the Anion-Assisted Dimer Structure by Epstein, Todd M, Yu, Bao-Zhu, Pan, Ying H, Tutton, Stephen P, Maliwal, Badri P, Jain, Mahendra K, Bahnson, Brian J

“…Kinetic results in this paper show that, contrary to earlier reports, pig pancreatic prophospholipase A2 (proPLA2) does not hydrolyze monodisperse short chain…”
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Subtelomeric p53 binding prevents accumulation of DNA damage at human telomeres by Tutton, Stephen, Azzam, Greggory A, Stong, Nicholas, Vladimirova, Olga, Wiedmer, Andreas, Monteith, Jessica A, Beishline, Kate, Wang, Zhuo, Deng, Zhong, Riethman, Harold, McMahon, Steven B, Murphy, Maureen, Lieberman, Paul M

“…Telomeres and tumor suppressor protein TP53 (p53) function in genome protection, but a direct role of p53 at telomeres has not yet been described. Here, we…”
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An interdomain helix in IRE1α mediates the conformational change required for the sensor's activation by Ricci, Daniela, Tutton, Stephen, Marrocco, Ilaria, Ying, Mingjie, Blumenthal, Daniel, Eletto, Daniela, Vargas, Jade, Boyle, Sarah, Fazelinia, Hossein, Qian, Lei, Suresh, Krishna, Taylor, Deanne, Paton, James C., Paton, Adrienne W., Tang, Chih-Hang Anthony, Hu, Chih-Chi Andrew, Radhakrishnan, Ravi, Gidalevitz, Tali, Argon, Yair

“…The unfolded protein response plays an evolutionarily conserved role in homeostasis, and its dysregulation often leads to human disease, including diabetes and…”
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Elevated telomere dysfunction in cells containing the African-centric Pro47Ser cancer-risk variant of TP53 by Tutton, Stephen, Deng, Zhong, Gulve, Nitish, Vladimirova, Olga, Beishline, Kate, Wiedmer, Andreas, Murphy, Maureen, Lieberman, Paul M

“…Subtelomeric transcription and chromatin can have a significant impact on telomere repeat maintenance and chromosome stability. We have previously found that…”
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The connector between the kinase and RNase domains of IRE1α differentially controls the activities of this stress sensor by Ricci, Daniela, Tutton, Stephen, Chomistek, Steven, Marrocco, Ilaria, Ying, Mingjie, Blumental, Daniel, Eletto, Daniela, Vargas, Jade, Boyle, Sarah, Fazelinia, Hossein, Paton, James, Paton, Adrienne, Tang, Anthony, Hu, Chih-Chi Andrew, Gidalevitz, Tali, Argon, Yair

“…Abstract only Inositol requiring enzyme 1 (IRE1α) is a sensor that responds to endoplasmic reticulum stress with self‐phosphorylation, oligomerization and…”
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Repression of E2F-4 Mediated Transcription and Growth by Hypophosphorylated pRb2/p130 in Human Prostate Cancer Cells by Tutton, Stephen P

“…A fundamental property of tumor cells is the ability to proliferate in an unscheduled manner, circumventing the cues which would otherwise prevent entry into,…”
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The Basis for k cat Impairment in Prophospholipase A 2 from the Anion-Assisted Dimer Structure by Epstein, Todd M., Yu, Bao-Zhu, Pan, Ying H., Tutton, Stephen P., Maliwal, Badri P., Jain, Mahendra K., Bahnson, Brian J.

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