Search Results - "Tuttle, Marcelle"

Comparison of Cas9 activators in multiple species by Chavez, Alejandro, Tuttle, Marcelle, Pruitt, Benjamin W, Ewen-Campen, Ben, Chari, Raj, Ter-Ovanesyan, Dmitry, Haque, Sabina J, Cecchi, Ryan J, Kowal, Emma J K, Buchthal, Joanna, Housden, Benjamin E, Perrimon, Norbert, Collins, James J, Church, George

“…A comparison of seven dCas9-based transcriptional activators shows that VPR, SAM, and Suntag perform best in cell lines from a variety of organisms. Several…”
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Highly efficient Cas9-mediated transcriptional programming by Chavez, Alejandro, Scheiman, Jonathan, Vora, Suhani, Pruitt, Benjamin W, Tuttle, Marcelle, P R Iyer, Eswar, Lin, Shuailiang, Kiani, Samira, Guzman, Christopher D, Wiegand, Daniel J, Ter-Ovanesyan, Dmitry, Braff, Jonathan L, Davidsohn, Noah, Housden, Benjamin E, Perrimon, Norbert, Weiss, Ron, Aach, John, Collins, James J, Church, George M

“…The fusion of three transcriptional activation domains to a nuclease-deficient Cas9 achieves robust induction of gene expression and can induce differentiation…”
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Epidemiology and Management of Patients With Kidney Disease and Heart Failure With Preserved Ejection Fraction by Tuttle, Marcelle L., Fang, James C., Sarnak, Mark J., McCallum, Wendy

“…Heart failure with preserved ejection fraction (HFpEF) comprises approximately one-half of all diagnoses of heart failure. There is significant overlap of this…”
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Coronary Artery Bypass Grafting Versus Percutaneous Coronary Intervention in Patients Receiving Dialysis: Is CABG Worth the Risk? by Tuttle, Marcelle L., Weiner, Daniel E.

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Relmapirazin, a new exogenous filtration marker, and more widespread use of measured GFR by Tuttle, Marcelle, Levey, Andrew S

“…Plasma or urinary clearance of exogenous filtration markers is required for assessment of measured glomerular filtration rate. Although multiple methods are…”
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Next stop for the CRISPR revolution: RNA‐guided epigenetic regulators by Vora, Suhani, Tuttle, Marcelle, Cheng, Jenny, Church, George

“…Clustered regularly interspaced short palindromic repeats (CRISPRs) and CRISPR‐associated (Cas) proteins offer a breakthrough platform for cheap, programmable,…”
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Comparison Between Longitudinal Kidney Function and Volume Changes in Association with Heart Failure Outcomes Among Discharged Patients in EVEREST: SA-PO709 by Oka, Tatsufumi, Tighiouart, Hocine, McCallum, Wendy I., Tuttle, Marcelle, Konstam, Marvin, Udelson, James, Sarnak, Mark J.

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Association of Tricuspid Regurgitant Jet Velocity with Kidney Function in Patients with Heart Failure with Preserved Ejection Fraction in TOPCAT: TH-PO199 by Oka, Tatsufumi, Tighiouart, Hocine, McCallum, Wendy I., Tuttle, Marcelle, Testani, Jeffrey M., Sarnak, Mark J.

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Therapeutic approaches for pulmonary hypertension in patients with chronic kidney disease by Tuttle, Marcelle, Sarnak, Mark J, Navaneethan, Sankar D

“…Pulmonary hypertension is a common comorbidity in patients with chronic kidney disease (CKD), but therapeutic options are limited. We discuss the epidemiology…”
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Cas9 gRNA engineering for genome editing, activation and repression by Kiani, Samira, Chavez, Alejandro, Tuttle, Marcelle, Hall, Richard N, Chari, Raj, Ter-Ovanesyan, Dmitry, Qian, Jason, Pruitt, Benjamin W, Beal, Jacob, Vora, Suhani, Buchthal, Joanna, Kowal, Emma J K, Ebrahimkhani, Mohammad R, Collins, James J, Weiss, Ron, Church, George

“…The length of a single guide RNA (gRNA) determines the function of Cas9. In this study 20-nt gRNAs allowed nuclease activity and genome editing, whereas 14-nt…”
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Abstract 11968: Association of Invasive Measures of Congestion With Short- and Long-Term Kidney Function Outcomes Among Patients With Acute Decompensated Heart Failure by Moises, Amanda I, Tighiouart, Hocine, Oka, Tatsufumi, Tuttle, Marcelle, Banlengchit, Run, Sarnak, Hannah, Ferguson, Katie, Testani, Jeffrey M, Kiernan, Michael S, Sarnak, Mark J, McCallum, Wendy

“…Abstract only Background: Reduced kidney function as evaluated by estimated glomerular filtration rate (eGFR) is a powerful risk factor for adverse outcomes…”
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Association of Pulmonary Arterial Pulsatility Index (PAPi) with Kidney Outcomes Among Patients Admitted for Acute Decompensated Heart Failure: TH-PO200 by Tuttle, Marcelle, Tighiouart, Hocine, Testani, Jeffrey M., Banlengchit, Run, Moises, Amanda I., Sarnak, Hannah L., Oka, Tatsufumi, Kiernan, Michael S., Sarnak, Mark J., McCallum, Wendy I.

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Association of Aortic Pulsatility Index with Clinical Outcomes and In-Hospital eGFR Slope Among Patients Admitted for Acute Decompensated Heart Failure Requiring Hemodynamic Monitoring: SA-PO136 by Banlengchit, Run, Tighiouart, Hocine, Tuttle, Marcelle, Moises, Amanda I., Sarnak, Hannah L., Testani, Jeffrey M., Oka, Tatsufumi, Kiernan, Michael S., Sarnak, Mark J., McCallum, Wendy I.

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Association of Acute eGFR Changes With Mortality and Heart Failure Hospitalizations Among Patients Admitted for Acute Heart Failure Requiring Hemodynamic Monitoring: FR-PO083 by Banlengchit, Run, Tighiouart, Hocine, Gillberg, Jake, Tuttle, Marcelle, Testani, Jeffrey M., Oka, Tatsufumi, Kiernan, Michael S., Sarnak, Mark J., McCallum, Wendy I.

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Association Between ACEI/ARB Use With Mortality, Heart Failure Admissions, and Kidney Failure Outcomes Among Patients Admitted for Acute Heart Failure Requiring Invasive Hemodynamic Monitoring: TH-PO603 by Tuttle, Marcelle, Tighiouart, Hocine, Gillberg, Jake, Banlengchit, Run, Oka, Tatsufumi, Testani, Jeffrey M., Kiernan, Michael S., Sarnak, Mark J., McCallum, Wendy I.

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Peak Tricuspid Regurgitation Jet Velocity and Kidney Outcomes in Patients With Heart Failure With Preserved Ejection Fraction by Oka, Tatsufumi, Tighiouart, Hocine, McCallum, Wendy, Tuttle, Marcelle, Testani, Jeffrey M., Sarnak, Mark J.

“…Although venous congestion secondary to elevated pulmonary artery pressure (PAP) has been hypothesized to worsen kidney function, the association of peak…”
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Precise Cas9 targeting enables genomic mutation prevention by Chavez, Alejandro, Pruitt, Benjamin W., Tuttle, Marcelle, Shapiro, Rebecca S., Cecchi, Ryan J., Winston, Jordan, Turczyk, Brian M., Tung, Michael, Collins, James J., Church, George M.

“…Here, we present a generalized method of guide RNA “tuning” that enables Cas9 to discriminate between two target sites that differ by a single-nucleotide…”
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An enhanced CRISPR repressor for targeted mammalian gene regulation by Yeo, Nan Cher, Chavez, Alejandro, Lance-Byrne, Alissa, Chan, Yingleong, Menn, David, Milanova, Denitsa, Kuo, Chih-Chung, Guo, Xiaoge, Sharma, Sumana, Tung, Angela, Cecchi, Ryan J., Tuttle, Marcelle, Pradhan, Swechchha, Lim, Elaine T., Davidsohn, Noah, Ebrahimkhani, Mo R., Collins, James J., Lewis, Nathan E., Kiani, Samira, Church, George M.

“…The RNA-guided endonuclease Cas9 can be converted into a programmable transcriptional repressor, but inefficiencies in target-gene silencing have limited its…”
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Comparative Analysis of Cas9 Activators Across Multiple Species by Chavez, Alejandro, Tuttle, Marcelle, Pruitt, Benjamin W, Ewen-Campen, Ben, Chari, Raj, Ter-Ovanesyan, Dmitry, Haque, Sabina J, Cecchi, Ryan J, Kowal, Emma J K, Buchthal, Joanna, Housden, Benjamin E, Perrimon, Norbert, Collins, James J, Church, George

“…Several groups have generated programmable transcription factors based on the versatile Cas9 protein, yet their relative potency and effectiveness across…”
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