Search Results - "Tutt, ANJ"

Abstract ES6-4: Parp inhibitors for brca 1/2 mutation associated breast cancer by Tutt, ANJ

“…Abstract More than 15 years ago we and others showed the use of potent PARP1 inhibitors (PARPi), that both inhibit the catalytic activity of the PARP1 enzyme…”
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Tumor-Infiltrating B Lymphocyte Profiling Identifies IgG-Biased, Clonally Expanded Prognostic Phenotypes in Triple-Negative Breast Cancer by Harris, Robert J, Cheung, Anthony, Ng, Joseph C F, Laddach, Roman, Chenoweth, Alicia M, Crescioli, Silvia, Fittall, Matthew, Dominguez-Rodriguez, Diana, Roberts, James, Levi, Dina, Liu, Fangfang, Alberts, Elena, Quist, Jelmar, Santaolalla, Aida, Pinder, Sarah E, Gillett, Cheryl, Hammar, Niklas, Irshad, Sheeba, Van Hemelrijck, Mieke, Dunn-Walters, Deborah K, Fraternali, Franca, Spicer, James F, Lacy, Katie E, Tsoka, Sophia, Grigoriadis, Anita, Tutt, Andrew N J, Karagiannis, Sophia N

“…In breast cancer, humoral immune responses may contribute to clinical outcomes, especially in more immunogenic subtypes. Here, we investigated B lymphocyte…”
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Do tumor infiltrating lymphocytes (TILs) predict benefits from trastuzumab therapy for HER2 positive breast cancer? Meta-analysis of individual patient data from 4097 women in 5 trials by Hills, Robert Kerrin, Bradley, Rosie, Braybrooke, Jeremy, Gray, Richard G., Taylor, Hannah, Denkert, Carsten, Badve, Sunil S., Kim, Rim S., Lacroix-Triki, Magali, Regan, Meredith M., Hayes, Daniel F., Dowsett, Mitchell, Tutt, Andrew NJ, Gelber, Richard D., Cameron, David A., Bergh, Jonas C. S., Swain, Sandra M., Michiels, Stefan, Loi, Sherene, Salgado, Roberto

“…508 Background: High TIL counts are associated with a lower risk of breast cancer recurrence, especially in women with ER negative, HER2 negative tumors and,…”
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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy by Smith, Graeme C. M, Ashworth, Alan, Farmer, Hannah, McCabe, Nuala, Lord, Christopher J, Tutt, Andrew N. J, Johnson, Damian A, Richardson, Tobias B, Santarosa, Manuela, Dillon, Krystyna J, Hickson, Ian, Knights, Charlotte, Martin, Niall M. B, Jackson, Stephen P

“…BRCA1 and BRCA2 are important for DNA double-strand break repair by homologous recombination, and mutations in these genes predispose to breast and other…”
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DSS1 is required for RAD51 focus formation and genomic stability in mammalian cells by Gudmundsdottir, Katrin, Lord, Christopher J, Witt, Emily, Tutt, Andrew N J, Ashworth, Alan

“…BRCA2 is a breast cancer susceptibility gene implicated in the repair of double‐strand breaks by homologous recombination with RAD51. BRCA2 associates with a…”
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PO-228 Comprehensive molecular characterisation of TNBCs expressing HORMAD1, a driver of homologous recombination deficiency by Quist, J, Mirza, H, Weekes, D, Nowinski, S, Cheang, MCU, Lord, CJ, Tutt, ANJ, Grigoriadis, A

“…IntroductionTriple-negative breast cancers (TNBCs) are characterised by increased tumour-infiltrating lymphocytes and the presence of complex compositions of…”
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Disruption of Brca2 increases the spontaneous mutation rate in vivo: synergism with ionizing radiation by Tutt, Andrew N J, van Oostrom, Conny Th M, Ross, Gillian M, van Steeg, Harry, Ashworth, Alan

“…The breast cancer predisposition gene BRCA2 encodes a protein involved in the repair of DNA double‐strand breaks, which arise spontaneously and following…”
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Enteropathy associated T cell lymphoma presenting as an isolated CNS lymphoma three years after diagnosis of coeliac disease: T cell receptor polymerase chain reaction studies failed to show the original enteropathy to be a clonal disorder by Tutt, A N, Brada, M, Sampson, S A

“…A case of enteropathy associated T cell lymphoma is reported in a 45 year old woman, presenting with isolated disease in the CNS, three years after diagnosis…”
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