Search Results - "Tutt, A N J"

Triple negative tumours: a critical review by Reis-Filho, J S, Tutt, A N J

“…Breast cancer is a heterogeneous disease that encompasses several distinct entities with remarkably different biological characteristics and clinical…”
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Exploiting the DNA repair defect in BRCA mutant cells in the design of new therapeutic strategies for cancer by Tutt, A N J, Lord, C J, McCabe, N, Farmer, H, Turner, N, Martin, N M, Jackson, S P, Smith, G C M, Ashworth, A

“…Individuals harboring germ-line mutations in the BRCA1 or BRCA2 genes are at highly elevated risk of a variety of cancers. Ten years of research has revealed…”
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The role of positron emission tomography in the management of colorectal cancer by Tutt, A. N. J., Plunkett, T. A., Barrington, S. F., Leslie, M. D.

“…Positron emission tomography (PET) is a functional imaging modality that has made the transition from the research enviroment to the clinical enviroment over…”
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Overall survival in the OlympiA phase Ill trial of adjuvant olaparib in patients with germime pathogenic variants in BRCA1/2 and high-risk, early breast cancer by Geyer, C. E., Garber, J. E., Gelber, R. D., Yothers, G., Taboada, M., Ross, L., Rastogi, P., Cui, K., Arahmani, A., Aktan, G., Armstrong, A. C., Arnedos, M., Balmana, J., Bergh, J., Bliss, J., Delaloge, S., Domchek, S. M., Eisen, A., Elsafy, F., Fein, L. E., Fielding, A., Ford, J. M., Friedman, S., Gelmon, K. A., Gianni, L., Gnant, M., Hollingsworth, S. J., Im, S. A., Jager, A., Lakhani, S. R., Janni, W., Linderholm, Barbro, Liu, T. W., Loman, N., Korde, L., Loibl, S., Lucas, P. C., Marme, F., de Duenas, E. M., McConnell, R., Phillips, K. A., Piccart, M., Rossi, G., Schmutzler, R., Senkus, E., Shao, Z., Sharma, P., Singer, C. F., Spanic, T., Stickeler, E., Toi, M., Traina, T. A., Viale, G., Zoppoli, G., Park, Y. H., Yerushalmi, R., Yang, H., Pang, D., Jung, K. H., Mailliez, A., Fan, Z., Tennevet, I., Zhang, J., Nagy, T., Sonke, G. S., Sun, Q., Parton, M., Colleoni, M. A., Schmidt, M., Brufsky, A. M., Razaq, W., Kaufman, B., Cameron, D., Campbell, C., Tutt, A. N. J., Johannsson, O. T.

“…Background: The randomized, double-blind OlympiA trial compared 1 year of the oral poly(adenosine diphosphate-ribose) polymerase inhibitor, olaparib, to…”
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VP1-2022: Pre-specified event driven analysis of Overall Survival (OS) in the OlympiA phase III trial of adjuvant olaparib (OL) in germline BRCA1/2 mutation (gBRCAm) associated breast cancer by Tutt, A.N.J., Garber, J., Gelber, R.D., Phillips, K-A., Eisen, A., Johannsson, O.T., Rastogi, P., Cui, K.Y., Im, S-A., Yerushalmi, R., Brufsky, A.M., Taboada, M., Rossi, G., Yothers, G., Singer, C., Fein, L.E., Loman, N., Cameron, D., Campbell, C., Geyer, C.E.

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Longitudinal profiling identifies co-occurring BRCA1/2 reversions, TP53BP1, RIF1 and PAXIP1 mutations in PARP inhibitor-resistant advanced breast cancer by Harvey-Jones, E, Raghunandan, M, Robbez-Masson, L, Magraner-Pardo, L, Alaguthurai, T, Yablonovitch, A, Yen, J, Xiao, H, Brough, R, Frankum, J, Song, F, Yeung, J, Savy, T, Gulati, A, Alexander, J, Kemp, H, Starling, C, Konde, A, Marlow, R, Cheang, M, Proszek, P, Hubank, M, Cai, M, Trendell, J, Lu, R, Liccardo, R, Ravindran, N, Llop-Guevara, A, Rodriguez, O, Balmana, J, Lukashchuk, N, Dorschner, M, Drusbosky, L, Roxanis, I, Serra, V, Haider, S, Pettitt, S J, Lord, C J, Tutt, A N J

“…Resistance to therapies that target homologous recombination deficiency (HRD) in breast cancer limits their overall effectiveness. Multiple, preclinically…”
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Phase I study of abiraterone acetate (AA) in patients (pts) with estrogen receptor– (ER) or androgen receptor (AR) –positive advanced breast carcinoma resistant to standard endocrine therapies by Basu, B., Ang, J. E., Crawley, D., Folkerd, E., Sarker, D., Blanco-Codesido, M., Moran, K., Wan, S., Dobbs, N., Raynaud, F., Johnston, S. R. D., Dowsett, M., Tutt, A. N. J., Spicer, J. F., Swanton, C., De Bono, J. S.

“…Abstract only…”
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Enteropathy associated T cell lymphoma presenting as an isolated CNS lymphoma three years after diagnosis of coeliac disease: T cell receptor polymerase chain reaction studies failed to show the original enteropathy to be a clonal disorder by Tutt, A N, Brada, M, Sampson, S A

“…A case of enteropathy associated T cell lymphoma is reported in a 45 year old woman, presenting with isolated disease in the CNS, three years after diagnosis…”
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