Search Results - "Tutill, H J"

BCRP expression does not result in resistance to STX140 in vivo, despite the increased expression of BCRP in A2780 cells in vitro after long-term STX140 exposure by Day, J M, Foster, P A, Tutill, H J, Newman, S P, Ho, Y T, Leese, M P, Potter, B V L, Reed, M J, Purohit, A

“…The anti-proliferative and anti-angiogenic properties of the endogenous oestrogen metabolite, 2-methoxyoestradiol (2-MeOE2), are enhanced in a series of…”
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Use of whole genome sequencing in the Dutch Acute HCV in HIV study: focus on transmitted antiviral resistance by Christiansen, M.T., Hullegie, S.J., Schutten, M., Einer-Jensen, K., Tutill, H.J., Breuer, J., Rijnders, B.J.A.

“…Within HIV-positive men having sex with men, the epidemic of hepatitis C virus (HCV) is ongoing. Transmission of resistant variants of HCV after failure of…”
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Design and validation of specific inhibitors of 17 -hydroxysteroid dehydrogenases for therapeutic application in breast and prostate cancer, and in endometriosis by Day, J. M, Tutill, H. J, Purohit, A., Reed, M. J

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The regulation and inhibition of 17β-hydroxysteroid dehydrogenase in breast cancer by Purohit, A., Tutill, H.J., Day, J.M., Chander, S.K., Lawrence, H.R., Allan, G.M., Fischer, D.S., Vicker, N., Newman, S.P., Potter, B.V.L., Reed, M.J.

“…17β-Hydroxysteroid dehydrogenase Type 1 (17β-HSD1) has a pivotal role in regulating the synthesis of oestradiol (E2) within breast tumours. In whole body…”
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E-Ring Modified Steroids as Novel Potent Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 by Fischer, Delphine S, Allan, Gillian M, Bubert, Christian, Vicker, Nigel, Smith, Andrew, Tutill, Helena J, Purohit, Atul, Wood, Lynn, Packham, Graham, Mahon, Mary F, Reed, Michael J, Potter, Barry V. L

“…17β-Hydroxysteroid dehydrogenases (17β-HSDs) are an important class of steroidogenic enzymes that regulate the bioavailability of active estrogens and…”
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The regulation and inhibition of 17beta-hydroxysteroid dehydrogenase in breast cancer by Purohit, A, Tutill, H J, Day, J M, Chander, S K, Lawrence, H R, Allan, G M, Fischer, D S, Vicker, N, Newman, S P, Potter, B V L, Reed, M J

“…17Beta-hydroxysteroid dehydrogenase Type 1 (17beta-HSD1) has a pivotal role in regulating the synthesis of oestradiol (E2) within breast tumours. In whole body…”
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Modification of Estrone at the 6, 16, and 17 Positions:  Novel Potent Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 by Allan, Gillian M, Lawrence, Harshani R, Cornet, Josephine, Bubert, Christian, Fischer, Delphine S, Vicker, Nigel, Smith, Andrew, Tutill, Helena J, Purohit, Atul, Day, Joanna M, Mahon, Mary F, Reed, Michael J, Potter, Barry V. L

“…The 17β-hydroxysteroid dehydrogenases (17β-HSDs) catalyze the interconversion between the oxidized and reduced forms of androgens and estrogens at the 17…”
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The role of 17β-hydroxysteroid dehydrogenases in modulating the activity of 2-methoxyestradiol in breast cancer cells by NEWMAN, Simon P, IRESON, Christopher R, TUTILL, Helena J, DAY, Joanna M, PARSONS, Michael F. C, LEESE, Mathew P, POTTER, Barry V. L, REED, Michael J, PUROHIT, Atul

“…Abstract The bis-sulfamoylated derivative of 2-methoxyestradiol (2-MeOE2), 2-methoxyestradiol-3,17-O,O-bis-sulfamate (2-MeOE2bisMATE), has shown potent…”
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Novel and Potent 17β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors by Lawrence, Harshani R, Vicker, Nigel, Allan, Gillian M, Smith, Andrew, Mahon, Mary F, Tutill, Helena J, Purohit, Atul, Reed, Michael J, Potter, Barry V. L

“…Structure-based drug design using the crystal structure of human 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) led to the discovery of novel, selective,…”
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17 beta -Hydroxysteroid dehydrogenase Type 1 and Type 2: Association between mRNA expression and activity in cell lines by Day, Joanna M, Tutill, Helena J, Newman, Simon P, Purohit, Atul, Lawrence, Harshani R, Vicker, Nigel, Potter, Barry VL, Reed, Michael J

“…17 beta -Hydroxysteroid dehydrogenases (17 beta -HSDs) are a family of enzymes that regulate steroid availability within a tissue by catalysing the…”
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17ß-hydroxysteroid dehydrogenase inhibitors by Day, J M, Tutill, H J, Purohit, A

“…17ß-hydroxysteroid dehydrogenases (17ß-HSDs) are enzymes which require NAD(P)(H) for activity and are responsible for reduction or oxidation of hormones, fatty…”
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