Search Results - "Tuthill, Ralph"

Southwest Oncology Group S0008: a phase III trial of high-dose interferon Alfa-2b versus cisplatin, vinblastine, and dacarbazine, plus interleukin-2 and interferon in patients with high-risk melanoma--an intergroup study of cancer and leukemia Group B, Children's Oncology Group, Eastern Cooperative Oncology Group, and Southwest Oncology Group by Flaherty, Lawrence E, Othus, Megan, Atkins, Michael B, Tuthill, Ralph J, Thompson, John A, Vetto, John T, Haluska, Frank G, Pappo, Alberto S, Sosman, Jeffrey A, Redman, Bruce G, Moon, James, Ribas, Antoni, Kirkwood, John M, Sondak, Vernon K

“…High-dose interferon (IFN) for 1 year (HDI) is the US Food and Drug Administration-approved adjuvant therapy for patients with high-risk melanoma. Efforts to…”
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A Phase 2 Trial of Complete Resection for Stage IV Melanoma: Results of Southwest Oncology Group Clinical Trial S9430 by SOSMAN, Jeffrey A, MOON, James, TUTHILL, Ralph J, WARNEKE, James A, VETTO, John T, REDMAN, Bruce G, LIU, P. Y, UNGER, Joseph M, FLAHERTY, Lawrence E, SONDAK, Vernon K

“…On the basis of retrospective experience at individual centers, it appears that patients with stage IV melanoma who undergo complete resection have a favorable…”
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A phase II trial of imatinib mesylate in merkel cell carcinoma (neuroendocrine carcinoma of the skin): A Southwest Oncology Group study (S0331) by Samlowski, Wolfram E, Moon, James, Tuthill, Ralph J, Heinrich, Michael C, Balzer-Haas, Naomi S, Merl, Stuart A, DeConti, Ronald C, Thompson, John A, Witter, Merle T, Flaherty, Lawrence E, Sondak, Vernon K

“…Imatinib mesylate (Gleevec) was evaluated as a treatment for Merkel cell carcinoma (MCC, neuroendocrine carcinoma of the skin) based on the identification of…”
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Adjuvant Immunotherapy of Resected, Intermediate-Thickness, Node-Negative Melanoma With an Allogeneic Tumor Vaccine: Overall Results of a Randomized Trial of the Southwest Oncology Group by SONDAK, Vernon K, LIU, P.-Y, NOYES, R. Dirk, FLAHERTY, Lawrence E, TUTHILL, Ralph J, KEMPF, Raymond A, UNGER, Joseph M, SOSMAN, Jeffrey A, THOMPSON, John A, WEISS, Geoffrey R, REDMAN, Bruce G, JAKOWATZ, James G

“…Patients with clinically negative nodes constitute over 85% of new melanoma cases. There is no adjuvant therapy for intermediate-thickness, node-negative…”
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Dual-color, break-apart fluorescence in situ hybridization for EWS gene rearrangement distinguishes clear cell sarcoma of soft tissue from malignant melanoma by Patel, Rajiv M, Downs-Kelly, Erinn, Weiss, Sharon W, Folpe, Andrew L, Tubbs, Raymond R, Tuthill, Ralph J, Goldblum, John R, Skacel, Marek

“…Clear cell sarcoma of soft tissue (malignant melanoma of soft parts) is a soft tissue sarcoma with melanocytic differentiation that typically occurs in the…”
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Detection of Copy Number Alterations in Metastatic Melanoma by a DNA Fluorescence In situ Hybridization Probe Panel and Array Comparative Genomic Hybridization: A Southwest Oncology Group Study (S9431) by Moore, Stephen R, Persons, Diane L, Sosman, Jeffrey A, Bobadilla, Dolores, Bedell, Victoria, Smith, David D, Wolman, Sandra R, Tuthill, Ralph J, Moon, Jim, Sondak, Vernon K, Slovak, Marilyn L

“…Purpose: Gene copy number alteration (CNA) is common in malignant melanoma and is associated with tumor development and progression. The concordance between…”
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A 48-year-old woman with an ecchymotic rash by Chatterjee, Soumya, Tuthill, Ralph J

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Re-inventing intratumoral immunotherapy for melanoma by Triozzi, Pierre L, Tuthill, Ralph J, Borden, Ernest

“…Immunotherapeutics have been applied intratumorally to manage accessible lesions and to induce systemic immunity in malignant melanoma. Intratumoral bacillus…”
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Failure of Senescence in the Dysplasia–Melanoma Sequence: Demonstration Using a Tissue Microarray and a Revised Paradigm for Melanoma by Tuthill, Ralph J, Reed, Richard J

“…In order to correlate changes in morphology to changes in molecular attributes, we constructed a tissue microarray of thin and thick melanomas selected to…”
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A case of recurrent pseudolymphomatous folliculitis: A mimic of cutaneous lymphoma by Kwon, Eun Ji, MD, Kristjansson, Arni K., MD, Meyerson, Howard J., MD, Fedele, Gregory M., MD, Tung, Rebecca C., MD, Sellheyer, Klaus, MD, Tuthill, Ralph J., MD, Honda, Kord S., MD, Gilliam, Anita C., MD, PhD, McNiff, Jennifer M., MD

“…Pseudolymphomatous folliculitis is a rare entity. We present a 62-year-old man with a recurrent solitary nodule on his nose requiring multiple excisions…”
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Adjuvant vaccine immunotherapy of resected, clinically node-negative melanoma: long-term outcome and impact of HLA class I antigen expression on overall survival by Carson, 3rd, William E, Unger, Joseph M, Sosman, Jeffrey A, Flaherty, Lawrence E, Tuthill, Ralph J, Porter, Mark J, Thompson, John A, Kempf, Raymond A, Othus, Megan, Ribas, Antoni, Sondak, Vernon K

“…Associations between HLA class I antigen expression and the efficacy of a melanoma vaccine (Melacine; Corixa Corp.) were initially described in stage IV…”
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A phase 2 trial of complete resection for stage IV melanoma by Sosman, Jeffrey A., Moon, James, Tuthill, Ralph J., Warneke, James A., Vetto, John T., Redman, Bruce G., Liu, P. Y., Unger, Joseph M., Flaherty, Lawrence E., Sondak, Vernon K.

“…BACKGROUND: On the basis of retrospective experience at individual centers, it appears that patients with stage IV melanoma who undergo complete resection have…”
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Risk assessment in localized primary cutaneous melanoma: A southwest oncology group study evaluating nine factors and a test of the Clark logistic regression prediction model by TUTHILL, Ralph J, UNGER, Joseph M, LIU, P. Y, FLAHERTY, Lawrence E, SONDAK, Vernon K

“…We studied 9 clinical and pathologic factors in 259 patients using Cox model regression analysis to determine which factors have independent predictive value…”
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Adenoid cystic carcinoma of the base of the tongue: Late metastasis to the pancreas by Falk, Gavin A, El-Hayek, Kevin, Morris-Stiff, Gareth, Tuthill, Ralph J, Winans, Charles G

“…Abstract Adenoid cystic carcinoma (ACC) is a relatively rare epithelial tumor of the salivary glands. We present a 64-year-old gentleman with ACC of the tongue…”
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A Unique Cause of Intestinal and Splenic Infarction in a Sickle Cell Trait Patient by Asfaw, Sofya H., Falk, Gavin A., Morris-Stiff, Gareth, Tuthill, Ralph J., Moorman, Matthew L., Samotowka, Michael A.

“…Sickle-cell trait is a common genetic abnormality in the African American population. A sickle-cell crisis in a patient with sickle-cell trait is uncommon at…”
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JAAD Grand Rounds quiz by Burdick, Laura M., MD, Hamrock, David, MD, Mawhorter, Steven, MD, Tuthill, Ralph, MD, Karai, Laszlo, MD, PhD

“…Learning objectives: At the conclusion of this learning activity, physician participants should be able to assess their own diagnostic and patient management…”
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Efficient identification of T‐cell clones associated with graft‐versus‐host disease in target tissue allows for subsequent detection in peripheral blood by Beck, Rose C., Wlodarski, Marcin, Gondek, Lukasz, Theil, Karl S., Tuthill, Ralph J., Sobeck, Ronald, Bolwell, Brian, Maciejewski, Jaroslaw P.

“…Summary Graft‐versus‐host disease (GVHD) causes severe morbidity and mortality in allogeneic haematopoietic stem cell transplantation (HSCT) because of…”
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Comprehensive analysis of 112 melanocytic skin lesions demonstrates microsatellite instability in melanomas and dysplastic nevi, but not in benign nevi by Hussein, Mahmoud R., Sun, Min, Tuthill, Ralph J., Roggero, Eduardo, Monti, Jorge A., Sudilovsky, Eulalia C., Wood, Gary S., Sudilovsky, Oscar

“…Introduction: Alterations in the length of DNA repetitive sequences (microsatellite instability (MSI)) represent distinct tumorigenic pathways associated with…”
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Alterations of mismatch repair protein expression in benign melanocytic nevi, melanocytic dysplastic nevi, and cutaneous malignant melanomas by HUSSEIN, Mahmoud R, ROGGERO, Eduardo, SUDILOVSKY, Eulalia C, TUTHILL, Ralph J, WOOD, Gary S, SUDILOVSKY, Oscar

“…Immunoperoxidase-staining methods were used to examine the expression of hMLH1, hMSH2, and hMSH6 mismatch repair (MMR) proteins in 50 melanocytic lesions…”
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Loss of heterozygosity, microsatellite instability, and mismatch repair protein alterations in the radial growth phase of cutaneous malignant melanomas by Hussein, Mahmoud R., Sun, Min, Roggero, Eduardo, Sudilovsky, Eulalia C., Tuthill, Ralph J., Wood, Gary S., Sudilovsky, Oscar

“…Little is known about genomic alterations during development of the radial growth phase (RGP) of cutaneous malignant melanomas (CMMs). In this investigation…”
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