Search Results - "Tuszynski, Jack A"

An Overview of Molecular Modeling for Drug Discovery with Specific Illustrative Examples of Applications by Aminpour, Maral, Montemagno, Carlo, Tuszynski, Jack A

“…In this paper we review the current status of high-performance computing applications in the general area of drug discovery. We provide an introduction to the…”
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A Review of the Recent Developments of Molecular Hybrids Targeting Tubulin Polymerization by Ebenezer, Oluwakemi, Shapi, Michael, Tuszynski, Jack A

“…Microtubules are cylindrical protein polymers formed from -tubulin heterodimers in the cytoplasm of eukaryotic cells. Microtubule disturbance may cause cell…”
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Study of the Myosin Relay Helix Peptide by Molecular Dynamics Simulations, Pump-Probe and 2D Infrared Spectroscopy by Freedman, Holly, Tuszynski, Jack A

“…The Davydov model was conjectured to describe how an amide I excitation created during ATP hydrolysis in myosin might be significant in providing energy to…”
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The Neurotransmission Basis of Post-Traumatic Stress Disorders by the Fear Conditioning Paradigm by Traina, Giovanna, Tuszynski, Jack A

“…Fear conditioning constitutes the best and most reproducible paradigm to study the neurobiological mechanisms underlying emotions. On the other hand, studies…”
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An Overview of the Biological Evaluation of Selected Nitrogen-Containing Heterocycle Medicinal Chemistry Compounds by Ebenezer, Oluwakemi, Jordaan, Maryam Amra, Carena, Gea, Bono, Tommaso, Shapi, Michael, Tuszynski, Jack A.

“…Heterocyclic compounds are a class of compounds of natural origin with favorable properties and hence have major pharmaceutical significance. They have an…”
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Modeling the structure of the frameshift-stimulatory pseudoknot in SARS-CoV-2 reveals multiple possible conformers by Omar, Sara Ibrahim, Zhao, Meng, Sekar, Rohith Vedhthaanth, Moghadam, Sahar Arbabi, Tuszynski, Jack A, Woodside, Michael T

“…The coronavirus causing the COVID-19 pandemic, SARS-CoV-2, uses -1 programmed ribosomal frameshifting (-1 PRF) to control the relative expression of viral…”
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Automatic prediction of tumour malignancy in breast cancer with fractal dimension by Chan, Alan, Tuszynski, Jack A.

“…Breast cancer is one of the most prevalent types of cancer today in women. The main avenue of diagnosis is through manual examination of histopathology tissue…”
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Development of Novel siRNA Therapeutics: A Review with a Focus on Inclisiran for the Treatment of Hypercholesterolemia by Ebenezer, Oluwakemi, Comoglio, Pietro, Wong, Gane Ka-Shu, Tuszynski, Jack A

“…Over the past two decades, it was discovered that introducing synthetic small interfering RNAs (siRNAs) into the cytoplasm facilitates effective gene-targeted…”
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The zinc dyshomeostasis hypothesis of Alzheimer's disease by Craddock, Travis J A, Tuszynski, Jack A, Chopra, Deepak, Casey, Noel, Goldstein, Lee E, Hameroff, Stuart R, Tanzi, Rudolph E

“…Alzheimer's disease (AD) is the most common form of dementia in the elderly. Hallmark AD neuropathology includes extracellular amyloid plaques composed largely…”
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Tubulin's response to external electric fields by molecular dynamics simulations by Timmons, Joshua J, Preto, Jordane, Tuszynski, Jack A, Wong, Eric T

“…Tubulin heterodimers are the building blocks of microtubules and disruption of their dynamics is exploited in the treatment of cancer. Electric fields at…”
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Molecular signaling network complexity is correlated with cancer patient survivability by Breitkreutz, Dylan, Hlatky, Lynn, Rietman, Edward, Tuszynski, Jack A.

“…The 5-y survival for cancer patients after diagnosis and treatment is strongly dependent on tumor type. Prostate cancer patients have a > 99% chance of…”
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From quantum chemistry to quantum biology: a path toward consciousness by Tuszynski, Jack A

“…This paper presents a historical overview of quantum physics methodology's development and application to various science fields beyond physics, especially…”
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Holographic Brain Theory: Super-Radiance, Memory Capacity and Control Theory by Nishiyama, Akihiro, Tanaka, Shigenori, Tuszynski, Jack A, Tsenkova, Roumiana

“…We investigate Quantum Electrodynamics corresponding to the holographic brain theory introduced by Pribram to describe memory in the human brain. First, we…”
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The feasibility of coherent energy transfer in microtubules by Craddock, Travis John Adrian, Friesen, Douglas, Mane, Jonathan, Hameroff, Stuart, Tuszynski, Jack A.

“…It was once purported that biological systems were far too ‘warm and wet’ to support quantum phenomena mainly owing to thermal effects disrupting quantum…”
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Toward a holographic brain paradigm: a lipid-centric model of brain functioning by Cavaglià, Marco, Deriu, Marco A, Tuszynski, Jack A

“…Due to the stimulation of neuronal membrane dipoles by action potentials, under suitable conditions coherent dipole oscillations can be formed. We argue that…”
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Cytoskeletal signaling: is memory encoded in microtubule lattices by CaMKII phosphorylation? by Craddock, Travis J A, Tuszynski, Jack A, Hameroff, Stuart

“…Memory is attributed to strengthened synaptic connections among particular brain neurons, yet synaptic membrane components are transient, whereas memories can…”
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Gibbs Energy and Gene Expression Combined as a New Technique for Selecting Drug Targets for Inhibiting Specific Protein–Protein Interactions by Rietman, Edward A, Siegelmann, Hava T, Klement, Giannoula Lakka, Tuszynski, Jack A

“…One of the most important aspects of successful cancer therapy is the identification of a target protein for inhibition interaction. Conventionally, this…”
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Computational Prediction of the Interaction of Ivermectin with Fibrinogen by Vottero, Paola, Tavernini, Scott, Santin, Alessandro D, Scheim, David E, Tuszynski, Jack A, Aminpour, Maral

“…Hypercoagulability and formation of extensive and difficult-to-lyse microclots are a hallmark of both acute COVID-19 and long COVID. Fibrinogen, when converted…”
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How COVID-19 Hijacks the Cytoskeleton: Therapeutic Implications by Aminpour, Maral, Hameroff, Stuart, Tuszynski, Jack A.

“…The SARS-CoV-2 virus invades and replicates within host cells by “hijacking” biomolecular machinery, gaining control of the microtubule cytoskeleton. After…”
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Novel Combretastatin A-4 Analogs-Design, Synthesis, and Antiproliferative and Anti-Tubulin Activity by Jędrzejczyk, Marta, Morabito, Benedetta, Żyżyńska-Granica, Barbara, Struga, Marta, Janczak, Jan, Aminpour, Maral, Tuszynski, Jack A, Huczyński, Adam

“…Combretastatins isolated from the tree belong to a group of closely related stilbenes. They are colchicine binding site inhibitors which disrupt the…”
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