Search Results - "Tussey, Lynda G"

Antigen Burden Is a Major Determinant of Human Immunodeficiency Virus–Specific CD8+ T Cell Maturation State: Potential Implications for Therapeutic Immunization by Tussey, Lynda G., Nair, Ushasree Sadasivan, Bachinsky, Margaret, Edwards, Bradley H., Bakari, Janna, Grimm, Karen, Joyce, Joseph, Vessey, Rupert, Steigbigel, Roy, Robertson, Michael N., Shiver, John W., Goepfert, Paul A.

“…The majority of untreated human immunodeficiency virus (HIV) type 1–infected individuals ultimately develop uncontrolled viremia and progressive disease…”
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The effect of early versus delayed challenge after vaccination in controlling SHIV 89.6P infection by Chavez, Leslie L, Davenport, Miles P, Shiver, John W, Tussey, Lynda G, Cox, Kara S, Bachinsky, Margaret, Wang, Fubao, Huang, Lingyi, Schleif, William A, Davies, Mary-Ellen, Tang, Aimin, Casimiro, Danilo R, Perelson, Alan S, Ribeiro, Ruy M

“…Abstract We sought to determine how effectively a CD8+ T cell inducing vaccine controls SHIV-89.6P infection in rhesus macaques at a range of challenge times…”
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Attenuation of Simian Immunodeficiency Virus SIVmac239 Infection by Prophylactic Immunization with DNA and Recombinant Adenoviral Vaccine Vectors Expressing Gag by CASIMIRO, Danilo R, FUBAO WANG, BAGCHI, Ansu, TUSSEY, Lynda G, BETT, Andrew J, FINNEFROCK, Adam C, FU, Tong-Ming, AIMIN TANG, WILSON, Keith A, MINCHUN CHEN, PERRY, Helen C, HEIDECKER, Gwendolyn J, SCHLEIF, William A, FREED, Daniel C, CARELLA, Anthony, PUNT, Kara S, SYKES, Kara J, LINGYI HUANG, AUSENSI, Virginia I, BACHINSKY, Margaret, SADASIVAN-NAIR, Usha, WATKINS, David I, EMINI, Emilio A, XIAOPING LIANG, SHIVER, John W, ZHANG, Zhi-Qiang, TOBERY, Timothy W, DAVIES, Mary-Ellen, MCDERMOTT, Adrian B, O'CONNOR, David H, FRIDMAN, Arthur

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Induction of antigen-specific CD8+ T cells, T helper cells, and protective levels of antibody in humans by particle-mediated administration of a hepatitis B virus DNA vaccine by Roy, Michael J, Wu, Mary S, Barr, Lori James, Fuller, James T, Tussey, Lynda G, Speller, Sue, Culp, Jerilyn, Burkholder, Joseph K, Swain, William F, Dixon, Russell M, Widera, Georg, Vessey, Rupert, King, Abbi, Ogg, Graham, Gallimore, Awen, Haynes, Joel R, Heydenburg Fuller, Deborah

“…A DNA vaccine against the hepatitis B virus (HBV) was evaluated for safety and induction of immune responses in 12 healthy, hepatitis-naı̈ve human volunteers…”
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Memory T cells and vaccines by Esser, Mark T., Marchese, Rocio D., Kierstead, Lisa S., Tussey, Lynda G., Wang, Fubao, Chirmule, Narendra, Washabaugh, Michael W.

“…T lymphocytes play a central role in the generation of a protective immune response in many microbial infections. After immunization, dendritic cells take up…”
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Mapping and binding analysis of peptides derived from the tumor-associated antigen survivin for eight HLA alleles by Bachinsky, Margaret M, Guillen, Darlene E, Patel, Sima R, Singleton, Judith, Chen, Chaoyuan, Soltis, Daniel A, Tussey, Lynda G

“…There is considerable interest in developing immunotherapeutic approaches to elicit tumor-specific CTL responses in cancer patients. Epitope-based approaches…”
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A Point Mutation in HLA-A0201 Results in Failure to Bind the TAP Complex and to Present Virus-Derived Peptides to CTL by Peace-Brewer, Amy L, Tussey, Lynda G, Matsui, Masanori, Li, Guoxuan, Quinn, Daniel G, Frelinger, Jeffrey A

“…Mutating the HLA-A*0201 heavy chain from threonine to lysine at position 134 (T134K) results in a molecule that presents exogenous peptide, but cannot present…”
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Different MHC class I alleles compete for presentation of overlapping viral epitopes by Tussey, Lynda G., Rowland-Jones, Sarah, Zheng, Timothy S., Androlewicz, Matthew J., Cresswell, Peter, Frelinger, Jeffrey A., McMichael, Andrew J.

“…We previously identified an HLA-B8 + donor, NW, whose lymphoblestoid cells failed to present a B8-restricted epitope from the influenza A nucleoprotein…”
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Analysis of mutant HLA-A2 molecules. Differential effects on peptide binding and CTL recognition by Tussey, LG, Matsui, M, Rowland-Jones, S, Warburton, R, Frelinger, JA, McMichael, A

“…Previous studies have identified several residues lining the groove of the HLA-A2.1 molecule that are critical for Ag presentation. However, it is not clear…”
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Genetic evidence for difference between intracellular and extracellular peptides in influenza A matrix peptide-specific CTL recognition by Matsui, M, Moots, RJ, Warburton, RJ, Peace-Brewer, AL, Tussey, LG, Quinn, DG, McMichael, AJ, Frelinger, JA

“…During the course of extensive mutagenesis of HLA-A2.1, we examined influenza A matrix peptide (FMP)-specific CTL recognition of HMy2.C1R (C1R) cells…”
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Engagement of a T cell receptor by major histocompatibility complex irrespective of peptide by Vessey, S J, Barouch, D H, McAdam, S N, Tussey, L G, Davenport, M A, O'Callaghan, C A, Bell, J I, McMichael, A J, Jakobsen, B K

“…T cell receptors (TCR) identify target cells presenting a ligand consisting of a major histocompatibility complex molecule (MHC) and an antigenic peptide. A…”
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Detergent enhances binding of a secreted HLA-A2 molecule to solid phase peptides by Tussey, L G, Frelinger, J A

“…We have constructed a secreted analogue (sA2) of the human class I molecule HLA-A2. sA2 was affinity purified both in the presence and absence of detergent and…”
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