Search Results - "Turville, Stuart G."

The HIV-1 proviral landscape reveals that Nef contributes to HIV-1 persistence in effector memory CD4+ T cells by Duette, Gabriel, Hiener, Bonnie, Morgan, Hannah, Mazur, Fernando G, Mathivanan, Vennila, Horsburgh, Bethany A, Fisher, Katie, Tong, Orion, Lee, Eunok, Ahn, Haelee, Shaik, Ansari, Fromentin, Rémi, Hoh, Rebecca, Bacchus-Souffan, Charline, Nasr, Najla, Cunningham, Anthony L, Hunt, Peter W, Chomont, Nicolas, Turville, Stuart G, Deeks, Steven G, Kelleher, Anthony D, Schlub, Timothy E, Palmer, Sarah

“…Despite long-term antiretroviral therapy (ART), HIV-1 persists within a reservoir of CD4+ T cells that contribute to viral rebound if treatment is interrupted…”
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HIV-1 infection of human macrophages directly induces viperin which inhibits viral production by Nasr, Najla, Maddocks, Susan, Turville, Stuart G., Harman, Andrew N., Woolger, Natalie, Helbig, Karla J., Wilkinson, John, Bye, Chris R., Wright, Thomas K., Rambukwelle, Dharshini, Donaghy, Heather, Beard, Michael R., Cunningham, Anthony L.

“…Macrophages are key target cells for HIV-1. HIV-1BaL induced a subset of interferon-stimulated genes in monocyte-derived macrophages (MDMs), which differed…”
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SARS-CoV-2 Omicron BA.5: Evolving tropism and evasion of potent humoral responses and resistance to clinical immunotherapeutics relative to viral variants of concern by Aggarwal, Anupriya, Akerman, Anouschka, Milogiannakis, Vanessa, Silva, Mariana Ruiz, Walker, Gregory, Stella, Alberto Ospina, Kindinger, Andrea, Angelovich, Thomas, Waring, Emily, Amatayakul-Chantler, Supavadee, Roth, Nathan, Manni, Sandro, Hauser, Thomas, Barnes, Thomas, Condylios, Anna, Yeang, Malinna, Wong, Maureen, Jean, Tyra, Foster, Charles S.P., Christ, Daniel, Hoppe, Alexandra Carey, Munier, Mee Ling, Darley, David, Churchill, Melissa, Stark, Damien J., Matthews, Gail, Rawlinson, William D., Kelleher, Anthony D., Turville, Stuart G.

“…Genetically distinct viral variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been recorded since January 2020. The introduction of…”
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Mobilization of HIV spread by diaphanous 2 dependent filopodia in infected dendritic cells by Aggarwal, Anupriya, Iemma, Tina L, Shih, Ivy, Newsome, Timothy P, McAllery, Samantha, Cunningham, Anthony L, Turville, Stuart G

“…Paramount to the success of persistent viral infection is the ability of viruses to navigate hostile environments en route to future targets. In response to…”
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Improvement of immune dysregulation in individuals with long COVID at 24-months following SARS-CoV-2 infection by Phetsouphanh, Chansavath, Jacka, Brendan, Ballouz, Sara, Jackson, Katherine J. L., Wilson, Daniel B., Manandhar, Bikash, Klemm, Vera, Tan, Hyon-Xhi, Wheatley, Adam, Aggarwal, Anupriya, Akerman, Anouschka, Milogiannakis, Vanessa, Starr, Mitchell, Cunningham, Phillip, Turville, Stuart G., Kent, Stephen J., Byrne, Anthony, Brew, Bruce J., Darley, David R., Dore, Gregory J., Kelleher, Anthony D., Matthews, Gail V.

“…This study investigates the humoral and cellular immune responses and health-related quality of life measures in individuals with mild to moderate long COVID…”
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Enhanced stability of the SARS CoV-2 spike glycoprotein following modification of an alanine cavity in the protein core by Poumbourios, Pantelis, Langer, Christine, Boo, Irene, Zakir, Tasnim, Center, Rob J, Akerman, Anouschka, Milogiannakis, Vanessa, Aggarwal, Anupriya, Johnstone, Bronte A, Ha, Jungmin, Coulibaly, Fasséli, Turville, Stuart G, Drummer, Heidi E

“…The spike (S) glycoprotein of SARS CoV-2 is the target of neutralizing antibodies (NAbs) that are crucial for vaccine effectiveness. The S1 subunit binds ACE2…”
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N-Linked Glycosylation Facilitates Sialic Acid-Independent Attachment and Entry of Influenza A Viruses into Cells Expressing DC-SIGN or L-SIGN by LONDRIGAN, Sarah L, TURVILLE, Stuart G, TATE, Michelle D, DENG, Yi-Mo, BROOKS, Andrew G, READING, Patrick C

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Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure by Faysal, K M Rifat, Walsh, James C, Renner, Nadine, Márquez, Chantal L, Shah, Vaibhav B, Tuckwell, Andrew J, Christie, Michelle P, Parker, Michael W, Turville, Stuart G, Towers, Greg J, James, Leo C, Jacques, David A, Böcking, Till

“…The HIV-1 capsid has emerged as a tractable target for antiretroviral therapy. Lenacapavir, developed by Gilead Sciences, is the first capsid-targeting drug…”
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HIV-1 entry and trans-infection of astrocytes involves CD81 vesicles by Gray, Lachlan R, Turville, Stuart G, Hitchen, Tina L, Cheng, Wan-Jung, Ellett, Anne M, Salimi, Hamid, Roche, Michael J, Wesselingh, Steve L, Gorry, Paul R, Churchill, Melissa J

“…Astrocytes are extensively infected with HIV-1 in vivo and play a significant role in the development of HIV-1-associated neurocognitive disorders. Despite…”
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Diversity of receptors binding HIV on dendritic cell subsets by Cunningham, Anthony L, Turville, Stuart G, Cameron, Paul U, Handley, Amanda, Lin, George, Pöhlmann, Stefan, Doms, Robert W

“…The ability of HIV-1 to use dendritic cells (DCs) for transport and to transfer virus to activated T cells in the lymph node may be crucial in early HIV-1…”
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Embedding of HIV Egress within Cortical F-Actin by Aggarwal, Anupriya, Stella, Alberto Ospina, Henry, Catherine C, Narayan, Kedar, Turville, Stuart G

“…F-Actin remodeling is important for the spread of HIV via cell-cell contacts; however, the mechanisms by which HIV corrupts the actin cytoskeleton are poorly…”
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The NRTIs lamivudine, stavudine and zidovudine have reduced HIV-1 inhibitory activity in astrocytes by Gray, Lachlan R, Tachedjian, Gilda, Ellett, Anne M, Roche, Michael J, Cheng, Wan-Jung, Guillemin, Gilles J, Brew, Bruce J, Turville, Stuart G, Wesselingh, Steve L, Gorry, Paul R, Churchill, Melissa J

“…HIV-1 establishes infection in astrocytes and macroage-lineage cells of the central nervous system (CNS). Certain antiretroviral drugs (ARVs) can penetrate the…”
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Rapid spread of the SARS-CoV-2 JN.1 lineage is associated with increased neutralization evasion by Zhang, Lu, Dopfer-Jablonka, Alexandra, Cossmann, Anne, Stankov, Metodi V., Graichen, Luise, Moldenhauer, Anna-Sophie, Fichter, Christina, Aggarwal, Anupriya, Turville, Stuart G., Behrens, Georg M.N., Pöhlmann, Stefan, Hoffmann, Markus

“…In July/August 2023, the highly mutated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) BA.2.86 lineage emerged and its descendant JN.1 is on…”
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Immunodeficiency virus uptake, turnover, and 2-phase transfer in human dendritic cells by Turville, Stuart G., Santos, John J., Frank, Ines, Cameron, Paul U., Wilkinson, John, Miranda-Saksena, Monica, Dable, Joanne, Stössel, Hella, Romani, Nikolaus, Piatak, Michael, Lifson, Jeffrey D., Pope, Melissa, Cunningham, Anthony L.

“…HIV-1 subverts antigen processing in dendritic cells (DCs) resulting in viral uptake, infection, and transfer to T cells. Although DCs bound monomeric gp120…”
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High-Titer Neutralizing Antibodies against the SARS-CoV-2 Delta Variant Induced by Alhydroxyquim-II-Adjuvanted Trimeric Spike Antigens by Counoupas, Claudio, Pino, Paco, Stella, Alberto O, Ashley, Caroline, Lukeman, Hannah, Bhattacharyya, Nayan D, Tada, Takuya, Anchisi, Stephanie, Metayer, Charles, Martinis, Jacopo, Aggarwal, Anupriya, Dcosta, Belinda M, Britton, Warwick J, Kint, Joeri, Wurm, Maria J, Landau, Nathaniel R, Steain, Megan, Turville, Stuart G, Wurm, Florian M, David, Sunil A, Triccas, James A

“…Global control of COVID-19 will require the deployment of vaccines capable of inducing long-term protective immunity against SARS-CoV-2 variants. In this…”
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The microvesicle component of HIV-1 inocula modulates dendritic cell infection and maturation and enhances adhesion to and activation of T lymphocytes by Mercier, Sarah K, Donaghy, Heather, Botting, Rachel A, Turville, Stuart G, Harman, Andrew N, Nasr, Najla, Ji, Hong, Kusebauch, Ulrike, Mendoza, Luis, Shteynberg, David, Sandgren, Kerrie, Simpson, Richard J, Moritz, Robert L, Cunningham, Anthony L

“…HIV-1 is taken up by immature monocyte derived dendritic cells (iMDDCs) into tetraspanin rich caves from which the virus can either be transferred to T…”
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Double-Stranded RNA Analog Poly(I:C) Inhibits Human Immunodeficiency Virus Amplification in Dendritic Cells via Type I Interferon-Mediated Activation of APOBEC3G by TRAPP, Susanna, DERBY, Nina R, SINGER, Rachel, SHAW, Andrew, WILLIAMS, Vennansha G, TURVILLE, Stuart G, BESS, Julian W, LIFSON, Jeffrey D, ROBBIANI, Melissa

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CD4-specific designed ankyrin repeat proteins are novel potent HIV entry inhibitors with unique characteristics by Schweizer, Andreas, Rusert, Peter, Berlinger, Livia, Ruprecht, Claudia R, Mann, Axel, Corthésy, Stéphanie, Turville, Stuart G, Aravantinou, Meropi, Fischer, Marek, Robbiani, Melissa, Amstutz, Patrick, Trkola, Alexandra

“…Here, we describe the generation of a novel type of HIV entry inhibitor using the recently developed Designed Ankyrin Repeat Protein (DARPin) technology…”
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Oligomerization of the Macrophage Mannose Receptor Enhances gp120-mediated Binding of HIV-1 by Lai, Joey, Bernhard, Oliver K., Turville, Stuart G., Harman, Andrew N., Wilkinson, John, Cunningham, Anthony L.

“…C-type lectin receptors expressed on the surface of dendritic cells and macrophages are able to bind glycoproteins of microbial pathogens via mannose, fucose,…”
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Efficacy of Carraguard-based microbicides in vivo despite variable in vitro activity by Turville, Stuart G, Aravantinou, Meropi, Miller, Todd, Kenney, Jessica, Teitelbaum, Aaron, Hu, Lieyu, Chudolij, Anne, Zydowsky, Tom M, Piatak, Jr, Michael, Bess, Jr, Julian W, Lifson, Jeffrey D, Blanchard, James, Gettie, Agegnehu, Robbiani, Melissa

“…Anti-HIV microbicides are being investigated in clinical trials and understanding how promising strategies work, coincident with demonstrating efficacy in…”
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