Search Results - "Turteltaub, K W"

Mass Spectrometric Characterization of an Acid-Labile Adduct Formed with 2‑Amino-1-methyl-6-phenylimidazo[4,5‑b]pyridine and Albumin in Humans by Wang, Yi, Villalta, Peter W, Peng, Lijuan, Dingley, Karen, Malfatti, Michael A, Turteltaub, K. W, Turesky, Robert J

“…2-Amino-1-methyl-6-phenylimidazo­[4,5-b]­pyridine (PhIP) is a carcinogenic heterocyclic aromatic amine formed during the high-temperature cooking of meats. The…”
Get full text

Methods of DNA adduct determination and their application to testing compounds for genotoxicity by Phillips, D. H., Farmer, P. B., Beland, F. A., Nath, R. G., Poirier, M. C., Reddy, M. V., Turteltaub, K. W.

“…At the International Workshop on Genotoxicity Test Procedures (IWGTP) held in Washington, DC (March 25–26, 1999), a working group considered the uses of DNA…”
Get full text

DNA and Protein Adduct Formation in the Colon and Blood of Humans after Exposure to a Dietary-relevant Dose of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by DINGLEY, K. H, CURTIS, K. D, NOWELL, S, FELTON, J. S, LANG, N. P, TURTELTAUB, K. W

“…Epidemiology studies have indicated that certain dietary components, including well-cooked meat, are risk determinants for colon cancer. Cooked meat can…”
Get full text

Characterization of a peptide adduct formed by N-acetoxy-2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine (PhIP), a reactive intermediate of the food carcinogen PhIP by Chepanoske, C.L, Brown, K, Turteltaub, K.W, Dingley, K.H

“…2-Amino-1-methyl-6-phenylimidazo[4,5- b]pyridine (PhIP) is a member of a class of compounds known as the heterocyclic amines (HCAs) that are formed in meat…”
Get full text

Trials and tribulations in the first three years in operation of the SSAMS for biomedical 14C-AMS at LLNL by Ognibene, T.J., Haack, K.W., Bench, G., Turteltaub, K.W.

“…We report on the first several years of operation of our recently installed 250 kV SSAMS at LLNL, purchased to replace our 1-MV AMS system for the measurement…”
Get full text

Accelerator mass spectrometry allows for cellular quantification of doxorubicin at femtomolar concentrations by DEGREGORIO, M. W, DINGLEY, K. H, WURZ, G. T, UBICK, E, TURTELTAUB, K. W

“…Accelerator mass spectrometry (AMS) is a highly sensitive analytical methodology used to quantify the content of radioisotopes, such as (14)C, in a sample. The…”
Get full text

An interface for the direct coupling of small liquid samples to AMS by Ognibene, T.J., Thomas, A.T., Daley, P.F., Bench, G., Turteltaub, K.W.

“…We describe the moving wire interface attached to the 1-MV AMS system at LLNL’s Center for Accelerator Mass Spectrometry for the analysis of nonvolatile liquid…”
Get full text

Operation of the “Small” BioAMS spectrometers at CAMS: Past and future prospects by Ognibene, T.J., Haack, K.W., Bench, G., Brown, T.A., Turteltaub, K.W.

“…A summary of results from the solid samples run on our compact 1MV AMS system over its 13.5years of operation is presented. On average 7065 samples per year…”
Get full text

The identification of [2-14C]2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine metabolites in humans by Malfatti, Michael A., Kulp, Kristen S., Knize, Mark G., Davis, Cindy, Massengill, Joyce P., Williams, Suzanne, Nowell, Susan, MacLeod, Stewart, Dingley, Karen H., Turteltaub, Kenneth W., Lang, Nicholas P., Felton, James S.

“…[2-14C]2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine ([14C]PhIP), a putative human carcinogenic heterocyclic amine found in well-done cooked meat, was…”
Get full text

Accelerator Mass Spectrometry in Biomedical Dosimetry: Relationship Between Low-Level Exposure and Covalent Binding of Heterocyclic Amine Carcinogens to DNA by Turteltaub, K. W., Felton, J. S., Gledhill, B. L., Vogel, J. S., Southon, J. R., Caffee, M. W., Finkel, R. C., Nelson, D. E., Proctor, I. D., Davis, J. C.

“…Accelerator mass spectrometry (AMS) is used to determine the amount of carcinogen covalently bound to mouse liver DNA (DNA adduct) following very low-level…”
Get full text

Macromolecular adduct formation and metabolism of heterocyclic amines in humans and rodents at low doses by Turteltaub, Kenneth W, Dingley, Karen H, Curtis, Kellie D, Malfatti, Michael A, Turesky, Robert J, Colin Garner, R, Felton, James S, Lang, Nicholas P

“…2-Amino-3,8-dimethylimidazo[4,5- f]quinoxaline (MeIQx) and 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine (PhIP) are heterocyclic amines formed during the…”
Get full text

Comparative biotransformation studies of MeIQx and PhIP in animal models and humans by Garner, R.C, Lightfoot, T.J, Cupid, B.C, Russell, D, Coxhead, J.M, Kutschera, W, Priller, A, Rom, W, Steier, P, Alexander, D.J, Leveson, S.H, Dingley, K.H, Mauthe, R.J, Turteltaub, K.W

“…MeIQx and PhIP are putative carcinogenic heterocyclic amines formed during the cooking of meat and fish. Using accelerator mass spectrometry, we have…”
Get full text

Dose-Dependent Binding of ortho-Phenylphenol to Protein but Not DNA in the Urinary Bladder of Male F344 Rats by Kwok, E.S.C, Buchholz, B.A, Vogel, J.S, Turteltaub, K.W, Eastmond, D.A

“…ortho-Phenylphenol (OPP) is a widely used fungicide and antibacterial agent that is also known to be highly effective in inducing bladder tumors in male F344…”
Get full text

Tissue distribution and macromolecular binding of extremely low doses of [14C]-benzene in B6C3F1 mice by CREEK, M. R, MANI, C, VOGEL, J. S, TURTELTAUB, K. W

“…The tissue distribution and macromolecular binding of benzene was studied over a dose range spanning nine-orders of magnitude to determine the nature of the…”
Get full text

Quantitative imaging microscopy for the sensitive detection of administered metal containing drugs in single cells and tissue slices—a demonstration using platinum based chemotherapeutic agents by Mauthe, R.J, Sideras-Haddad, E, Turteltaub, K.W, Bench, G

“…We describe the use of Nuclear microscopy (microbeam PIXE) for the quantitative micron scale analysis of platinum based chemotherapeutic agents in individual…”
Get full text

Covalent binding of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline to albumin and hemoglobin at environmentally relevant doses : Comparison of human subjects and F344 rats by DINGLEY, K. H, FREEMAN, S. P. H. T, NELSON, D. O, GARNER, R. C, TURTELTAUB, K. W

“…Covalent binding of the food-borne heterocyclic amine 2-amino-3, 8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) to albumin and hemoglobin (Hb), 3.5-6.0 hr after…”
Get full text

Investigation of the formation and accumulation of liver DNA adducts in mice chronically exposed to tamoxifen by MARTIN, E. A, CARTHEW, P, WHITE, I. N. H, HEYDON, R. T, GASKELL, M, MAUTHE, R. J, TURTELTAUB, K. W, SMITH, L. L

“…Tamoxifen was administered to three strains of female mice (B6C3F1, C57BL/6 and DBA/2) in short- and long-term studies to determine their ability to activate…”
Get full text

In vivo human metabolism of [2- 14C]2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine (PhIP) by Lang, Nicholas P., Nowell, Susan, Malfatti, Michael A., Kulp, Kristen S., Knize, Mark G., Davis, Cindy, Massengill, Joyce, Williams, Suzanne, MacLeod, Stewart, Dingley, Karen H., Felton, James S., Turteltaub, Kenneth W.

“…To better understand the interactions of the pathways of activation and detoxification on the metabolism of the putative carcinogen, PhIP, we administered a…”
Get full text

formation of AFB1-macromolecular adducts in rats and humans at dietary levels of exposure by Cupid, B.C, Lightfoot, T.J, Russell, D, Gant, S.J, Turner, P.C, Dingley, K.H, Curtis, K.D, Leveson, S.H, Turteltaub, K.W, Garner, R.C

Get full text

Species and Strain Comparisons in the Macromolecular Binding of Extremely Low Doses of [14C]Benzene in Rodents, Using Accelerator Mass Spectrometry by Mani, Chitra, Freeman, Stewart, Nelson, David O., Vogel, John S., Turteltaub, Kenneth W.

“…The kinetics of macromolecular binding of a 5 μg/kg body wt dose of [14C]benzene was studied over 48 h in B6C3F1, DBA/2, and C57BL/6 mice and Fischer rats to…”
Get full text