Emerging Functions of IL-33 in Homeostasis and Immunity

Emerging Functions of IL-33 in Homeostasis and Immunity

Our understanding of the functions of the IL-1 superfamily cytokine and damage-associated molecular pattern IL-33 continues to evolve with our understanding of homeostasis and immunity. The early findings that IL-33 is a potent driver of type 2 immune responses promoting parasite expulsion, but also...

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Bibliographic Details
Published in:Annual review of immunology Vol. 40; no. 1; pp. 15 - 43
Main Authors: Dwyer, Gaelen K, D'Cruz, Louise M, Turnquist, H th R
Format: Journal Article
Language:English
Published: United States Annual Reviews 26-04-2022
Subjects:
Animals
Cytokines
damage-associated molecular patterns
Homeostasis
Humans
Hypersensitivity
IL-33
Immunity, Innate
Interleukin-33
Lymphocytes
tissue repair
type 2 immunity
homeostasis
cytokines
damage-associated molecular patterns
IL-33
type 2 immunity
tissue repair
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Summary:Our understanding of the functions of the IL-1 superfamily cytokine and damage-associated molecular pattern IL-33 continues to evolve with our understanding of homeostasis and immunity. The early findings that IL-33 is a potent driver of type 2 immune responses promoting parasite expulsion, but also inflammatory diseases like allergy and asthma, have been further supported. Yet, as the importance of a type 2 response in tissue repair and homeostasis has emerged, so has the fundamental importance of IL-33 to these processes. In this review, we outline an evolving understanding of IL-33 immunobiology, paying particular attention to how IL-33 directs a network of ST2 + regulatory T cells, reparative and regulatory macrophages, and type 2 innate lymphoid cells that are fundamental to tissue development, homeostasis, and repair.
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ISSN:0732-0582
1545-3278
DOI:10.1146/annurev-immunol-101320-124243