Search Results - "Turner, Timothy J."

Comparative CNS Pharmacology of the Bruton’s Tyrosine Kinase (BTK) Inhibitor Tolebrutinib Versus Other BTK Inhibitor Candidates for Treating Multiple Sclerosis by Turner, Timothy J., Brun, Pricilla, Gruber, Ross C., Ofengeim, Dimitry

“…Background and objectives Tolebrutinib is a covalent BTK inhibitor designed and selected for potency and CNS exposure to optimize impact on BTK-dependent…”
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A phase I trial assessing the safety, pharmacokinetics, cerebrospinal fluid penetrance, and food effect of BTK inhibitor tolebrutinib in healthy volunteers by Cabanis, Marie‐José, Nicolas, Olivier, Vitse, Olivier, Jan, Christelle, Brun, Priscilla, Soubayrol, Patrick, Smith, William B., Turner, Timothy J., Krupka, Emmanuel

“…Tolebrutinib is an oral, brain‐penetrant, covalent Bruton's tyrosine kinase inhibitor in development to treat multiple sclerosis at 60 mg/day with food. A…”
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Teriflunomide Inhibits JCPyV Infection and Spread in Glial Cells and Choroid Plexus Epithelial Cells by O'Hara, Bethany A, Gee, Gretchen V, Haley, Sheila A, Morris-Love, Jenna, Nyblade, Charlotte, Nieves, Chris, Hanson, Barbara A, Dang, Xin, Turner, Timothy J, Chavin, Jeffrey M, Lublin, Alex, Koralnik, Igor J, Atwood, Walter J

“…Several classes of immunomodulators are used for treating relapsing-remitting multiple sclerosis (RRMS). Most of these disease-modifying therapies, except…”
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Bruton tyrosine kinase inhibitors for multiple sclerosis by Krämer, Julia, Bar-Or, Amit, Turner, Timothy J., Wiendl, Heinz

“…Current therapies for multiple sclerosis (MS) reduce both relapses and relapse-associated worsening of disability, which is assumed to be mainly associated…”
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BTK regulates microglial function and neuroinflammation in human stem cell models and mouse models of multiple sclerosis by Gruber, Ross C., Wirak, Gregory S., Blazier, Anna S., Lee, Lan, Dufault, Michael R., Hagan, Nellwyn, Chretien, Nathalie, LaMorte, Michael, Hammond, Timothy R., Cheong, Agnes, Ryan, Sean K., Macklin, Andrew, Zhang, Mindy, Pande, Nilesh, Havari, Evis, Turner, Timothy J., Chomyk, Anthony, Christie, Emilie, Trapp, Bruce D., Ofengeim, Dimitry

“…Neuroinflammation in the central nervous system (CNS), driven largely by resident phagocytes, has been proposed as a significant contributor to disability…”
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Ral-GTPase Influences the Regulation of the Readily Releasable Pool of Synaptic Vesicles by Polzin, Atsuko, Shipitsin, Michail, Goi, Takanori, Feig, Larry A., Turner, Timothy J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Enhanced G protein-dependent modulation of excitatory synaptic transmission in the cerebellum of the Ca2+ channel-mutant mouse, tottering by Zhou, Yu Dong, Turner, Timothy J., Dunlap, Kathleen

“…Tottering , a mouse model for absence epilepsy and cerebellar ataxia, carries a mutation in the gene encoding class A (P/Q-type) Ca 2+ channels, the dominant…”
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Calcium as a Coagonist of Inositol 1,4,5-Trisphosphate-Induced Calcium Release by Finch, Elizabeth A., Turner, Timothy J., Goldin, Stanley M.

“…Inositol 1,4,5-trisphosphate (IP$_3$)-induced calcium release from intracellular stores is a regulator of cytosolic-free calcium levels. The subsecond kinetics…”
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Effect of Teriflunomide on Cells From Patients With Human T-cell Lymphotropic Virus Type 1–Associated Neurologic Disease by Enose-Akahata, Yoshimi, Ngouth, Nyater, Ohayon, Joan, Mandel, Matt, Chavin, Jeffrey, Turner, Timothy J., Jacobson, Steven

“…To test the hypothesis that teriflunomide can reduce ex vivo spontaneous proliferation of peripheral blood mononuclear cells (PBMCs) from patients with human…”
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Nicotine Enhancement of Dopamine Release by a Calcium-Dependent Increase in the Size of the Readily Releasable Pool of Synaptic Vesicles by Turner, Timothy J

“…A major factor underlying compulsive tobacco use is nicotine-induced modulation of dopamine release in the mesolimbic reward pathway (Wise and Rompre, 1989)…”
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Multiple Ca(2positive) channel types coexist to regulate synaptosomal neurotransmitter release by Turner, Timothy J, Adams, Michael E, Dunlap, Kathleen

“…The results of a study suggest that multiple calcium2plus channel types coexist to regulate neurosecretion under normal physiological conditions in the…”
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Adopting orphaned drugs: developing multidrug regimens using generic drugs by Turner, Timothy J, Bascomb, Newell, Maki, John, Rao, Navaneetha, Young, Fredric S

“…We define ‘orphaned drugs’ as those proven drugs that have been abandoned because of a perceived inability to develop them commercially for new indications…”
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Comparative CNS Pharmacology of Tolebrutinib Versus Other BTK Inhibitor Candidates for Treating MS (S46.007) by Turner, Timothy J., Nicolas, Olivier, Brun, Priscilla, Ofengeim, Dimitry

“…Abstract only…”
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Calcium channels coupled to glutamate release identified by omega-Aga-IVA by Turner, T.J. (Tufts University School of Medicine, Boston, MA), Adams, M.E, Dunlap, K

“…Presynaptic calcium channels are crucial elements of neuronal excitation-secretion coupling. In mammalian brain, they have been difficult to characterize…”
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Safety and Clinical Efficacy Outcomes From the Long-term Extension Study of Tolebrutinib in Participants With Relapsing Multiple Sclerosis: 2.5-Year Results (S16.010) by Oh, Jiwon, Syed, Sana, Li, Tong, Salloum, Naji, Turner, Timothy J., Fox, Robert J.

“…Abstract only…”
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Inositol 1,4,5-Trisphosphate and Calcium Regulate the Calcium Channel Function of the Hepatic Inositol 1,4,5-Trisphosphate Receptor by Dufour, Jean-François, Arias, Irwin M., Turner, Timothy J.

“…The regulation of the inositol 1,4,5-trisphosphate (IP3) receptor in liver was analyzed using a novel superfusion method. Hepatic microsomes were loaded with…”
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Comparison of mechanical agitation and calcium shock methods for preparation of a membrane fraction enriched in olfactory cilia by WASHBURN, Katrina B, TURNER, Timothy J, TALAMO, Barbara R

“…Calcium plays an important regulatory role in olfactory signal transduction. Many investigations into the regulation of the olfactory signaling pathway have…”
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Effect of teriflunomide on JCPyV infection in primary astrocytes and choroid plexus epithelial cells (3978) by Atwood, Walter J., Turner, Timothy J., Chavin, Jeffrey, Guikema, Benjamin, O’Hara, Bethany A.

“…Abstract only…”
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Teriflunomide Reduces Spontaneous Lymphoproliferation of Peripheral Blood Mononuclear Cells From Patients With Human T-Lymphotropic Virus (HTLV)-1–Associated Myelopathy/Tropical Spastic Paraparesis (P4.9-004) by Akahata, Yoshimi, Nyater, Ngouth, Ohayon, Joan, Mandel, Matthew, Chavin, Jeffrey, Turner, Timothy J., Jacobson, Steven

“…Abstract only…”
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Sécurité d’emploi et efficacité clinique du tolébrutinib dans l’étude d’extension à long terme chez des patients atteints de SEP récurrente : résultats à 2 ans by Oh, Jiwon, Syed, Sana, Orogun, Larry, Xu, Zhixing, Turner, Timothy J., Fox, Robert J.

“…amel.gheribbenblidia@sanofi.com (A. Gherib Benblidia). Dans une étude de phase 2b, le tolébrutinib, un inhibiteur de la tyrosine kinase qui pénètre le SNC, a…”
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