Search Results - "Turner, T. Robert"

Subsite Specificity of Memapsin 2 (β-Secretase):  Implications for Inhibitor Design by Turner, Robert T, Koelsch, Gerald, Hong, Lin, Castenheira, Pedro, Ghosh, Arun, Tang, Jordan

“…Memapsin 2 is the protease known as β-secretase whose action on β-amyloid precursor protein leads to the production of the β-amyloid (Aβ) peptide. Since the…”
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Crystal Structure of Memapsin 2 (β-Secretase) in Complex with an Inhibitor OM00-3 by Hong, Lin, Turner, Robert T, Koelsch, Gerald, Shin, Dongoo, Ghosh, Arun K, Tang, Jordan

“…The structure of the catalytic domain of human memapsin 2 bound to an inhibitor OM00-3 (Glu-Leu-Asp-Leu*Ala-Val-Glu-Phe, K i = 0.3 nM, the asterisk denotes the…”
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Structural Locations and Functional Roles of New Subsites S5, S6, and S7 in Memapsin 2 (β-Secretase) by Turner, Robert T, Hong, Lin, Koelsch, Gerald, Ghosh, Arun K, Tang, Jordan

“…Memapsin 2 (β-secretase) is the membrane-anchored aspartic protease that initiates the cleavage of β-amyloid precursor protein (APP), leading to the production…”
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Theoretically-driven infrastructure for supporting health care teams training at a military treatment facility by Turner, Jr, T Robert, Parodi, Andrea

“…Designated a Department of Defense Team Resource Center (TRC) in 2008, Naval Medical Center Portsmouth (NMCP) currently hosts three tri-service health care…”
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Internalization of Exogenously Added Memapsin 2 (β-Secretase) Ectodomain by Cells Is Mediated by Amyloid Precursor Protein by Huang, Xiang-Ping, Chang, Wan-Pin, Koelsch, Gerald, Turner, Robert T., Lupu, Florea, Tang, Jordan

“…Memapsin 2 (β-secretase) is the protease that initiates cleavage of amyloid precursor protein (APP) leading to the production of amyloid-β (Aβ) peptide and the…”
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The trend toward minimally invasive complex abdominal wall reconstruction: is it worth it? by Belyansky, Igor, Weltz, Adam S., Sibia, Udai S., Turcotte, Justin J., Taylor, Haley, Zahiri, H. Reza, Turner, T. Robert, Park, Adrian

“…Background Open abdominal wall reconstruction (AWR) was previously one of the only methods available to treat complex ventral hernias. We set out to identify…”
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Specificity of Memapsin 1 and Its Implications on the Design of Memapsin 2 (β-Secretase) Inhibitor Selectivity by Turner, Robert T, Loy, Jeffrey A, Nguyen, Chan, Devasamudram, Thippeswamy, Ghosh, Arun K, Koelsch, Gerald, Tang, Jordan

“…Memapsin 1 is closely homologous to memapsin 2 (BACE), or β-secretase, whose action on β-amyloid precursor protein (APP) leads to the production of β-amyloid…”
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Standardized Patient Encounters: Periodic Versus Postencounter Evaluation of Nontechnical Clinical Performance by Turner, T Robert, Scerbo, Mark W, Gliva-McConvey, Gayle A, Wallace, Amelia M

“…INTRODUCTIONStandardized patients are a beneficial component of modern healthcare education and training, but few studies have explored cognitive factors…”
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Study of memapsin 2 (beta-secretase) and strategy of inhibitor design by Tang, Jordan, Ghosh, Arun K, Hong, Lin, Koelsch, Gerald, Turner, 3rd, Robert T, Chang, Wanpin

“…The discovery that beta-secretase is a membrane-anchored aspartic protease memapsin 2 has stimulated much interest in the design and testing of its inhibitors…”
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Real-time Microdialysis for aβ Inhibition And Pk/pd Analysis in A Nonhuman Primate Model: In Vivo Efficacy of a Bace-1 Inhibitor by Yu, Jeremy, Koelsch, Gerald, Li, Aiqun, Turner, Robert T, Bilcer, Geoffrey M, Miyake, Akira, Hamakawa, Nozomu, Terashita, Shigeyuki, Matsuoka, Nobuya, Hey, John A

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In vivo efficacy of BACE-1 inhibitor CTS21166 (ASP1702) in rat CNS compartments by Yu, Jeremy, Koelsch, Gerald, Li, Aiqun, Turner, Robert T, Bilcer, Geoffrey M, Grove, Carl, Hsu, Henry H, Shitaka, Yoshitsugu, Hamakawa, Nozomu, Terashita, Shigeyuki, Matsuoka, Nobuya, Tang, Jordan, Ghosh, Arun K, Hey, John A

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Memapsin 2, a drug target for Alzheimer's disease by Koelsch, Gerald, Turner, 3rd, Robert T, Hong, Lin, Ghosh, Arun K, Tang, Jordan

“…Mempasin 2, a beta-secretase, is the membrane-anchored aspartic protease that initiates the cleavage of amyloid precursor protein leading to the production of…”
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Subsite Specificity of Memapsin 2 (β-Secretase):  Implications for Inhibitor Design by Turner, Robert T, Koelsch, Gerald, Hong, Lin, Castanheira, Pedro, Ermolieff, Jacques, Ghosh, Arun K, Tang, Jordan

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Structural Locations and Functional Roles of New Subsites S 5 , S 6 , and S 7 in Memapsin 2 (β-Secretase) by Turner, Robert T., Hong, Lin, Koelsch, Gerald, Ghosh, Arun K., Tang, Jordan

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Evaluating Physician-to-Patient Communication: The Effects of Concurrent and Retrospective Assessment on Verbal and Nonverbal Recall by Turner, T. Robert, Scerbo, Mark W., Gliva-McConvey, Gayle A., Wallace, Amelia M.

“…Research has established that human patient simulators (i.e., standardized patients) are a highly beneficial component of modern medical education and…”
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P4‐169: Real‐time Microdialysis for aβ Inhibition And Pk/pd Analysis in A Nonhuman Primate Model: In Vivo Efficacy of a Bace‐1 Inhibitor by Yu, Jeremy, Koelsch, Gerald, Li, Aiqun, Turner, Robert T., Bilcer, Geoffrey M., Miyake, Akira, Hamakawa, Nozomu, Terashita, Shigeyuki, Matsuoka, Nobuya, Hey, John A.

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Evaluating Visual and Haptic Feedback on a Virtual Reality Simulator for Orthopedic Bone Pinning by Turner, T. Robert, Scerbo, Mark W., Meglan, Dwight, Waddington, Robert

“…The Simulation-Based Open Surgery Training System (SOSTS) is a virtual reality simulator designed to provide training on a simulated orthopedic bone pinning…”
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P3‐298: In vivo efficacy of BACE‐1 inhibitor CTS21166 (ASP1702) in rat CNS compartments by Yu, Jeremy, Koelsch, Gerald, Li, Aiqun, Turner, Robert T., Bilcer, Geoffrey M., Grove, Carl, Hsu, Henry H., Shitaka, Yoshitsugu, Hamakawa, Nozomu, Terashita, Shigeyuki, Matsuoka, Nobuya, Tang, Jordan, Ghosh, Arun K., Hey, John A.

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Tithe Reform in the English Church, 1830-1836 by Turner, Robert T.

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P1-228 Internalization of exogenously added memapsin 2(β-secretase) ectodomain into cells is mediated by amyloid precursor protein by Huang, Xiangping, Chang, Wan-Pin, Koelsch, Gerald, Turner, Robert T., Lupu, Florea, Tang, Jordan

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