Search Results - "Turner, Katharine L"

Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP2 Receptor Antagonist for Treatment of Asthma by Sandham, David A, Barker, Lucy, Brown, Lyndon, Brown, Zarin, Budd, David, Charlton, Steven J, Chatterjee, Devnandan, Cox, Brian, Dubois, Gerald, Duggan, Nicholas, Hall, Edward, Hatto, Julia, Maas, Janet, Manini, Jodie, Profit, Rachael, Riddy, Darren, Ritchie, Catherine, Sohal, Bindi, Shaw, Duncan, Stringer, Rowan, Sykes, David A, Thomas, Matthew, Turner, Katharine L, Watson, Simon J, West, Ryan, Willard, Elisabeth, Williams, Gareth, Willis, Jennifer

“…Further optimization of an initial DP2 receptor antagonist clinical candidate NVP-QAV680 led to the discovery of a follow-up molecule…”
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Potent and selective xanthine-based inhibitors of phosphodiesterase 5 by Arnold, Nichola J., Arnold, Ruth, Beer, David, Bhalay, Gurdip, Collingwood, Stephen P., Craig, Sarah, Devereux, Nicholas, Dodds, Mark, Dunstan, Andrew R., Fairhurst, Robin A., Farr, David, Fullerton, Joseph D., Glen, Angela, Gomez, Sylvie, Haberthuer, Sandra, Hatto, Julia D.I., Howes, Colin, Jones, Darryl, Keller, Thomas H., Leuenberger, Beate, Moser, Heinz E., Muller, Irene, Naef, Reto, Nicklin, Paul A., Sandham, David A., Turner, Katharine L., Tweed, Morris F., Watson, Simon J., Zurini, Mauro

“…Inhibitors of PDE5 are useful therapeutic agents for treatment of erectile dysfunction. A series of novel xanthine derivatives has been identified as potent…”
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An investigation into the structure-activity relationships associated with the systematic modification of the β(2)-adrenoceptor agonist indacaterol by Beattie, David, Beer, David, Bradley, Michelle E, Bruce, Ian, Charlton, Steven J, Cuenoud, Bernard M, Fairhurst, Robin A, Farr, David, Fozard, John R, Janus, Diana, Rosethorne, Elizabeth M, Sandham, David A, Sykes, David A, Trifilieff, Alexandre, Turner, Katharine L, Wissler, Elke

“…The synthesis of a series of indacaterol analogues in which each of the three structural regions of indacaterol are modified in a systematic manner is…”
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Discovery and characterization of NVP-QAV680, a potent and selective CRTh2 receptor antagonist suitable for clinical testing in allergic diseases by Sandham, David A., Arnold, Nicola, Aschauer, Heinrich, Bala, Kamlesh, Barker, Lucy, Brown, Lyndon, Brown, Zarin, Budd, David, Cox, Brian, Docx, Cerys, Dubois, Gerald, Duggan, Nicholas, England, Karen, Everatt, Brian, Furegati, Marcus, Hall, Edward, Kalthoff, Frank, King, Anna, Leblanc, Catherine J., Manini, Jodie, Meingassner, Josef, Profit, Rachael, Schmidt, Alfred, Simmons, Jennifer, Sohal, Bindi, Stringer, Rowan, Thomas, Matthew, Turner, Katharine L., Walker, Christoph, Watson, Simon J., Westwick, John, Willis, Jennifer, Williams, Gareth, Wilson, Caroline

“…Optimization of a 7-azaindole-3-acetic acid CRTh2 receptor antagonist chemotype derived from high throughput screening furnished a highly selective compound…”
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7-Azaindole-3-acetic acid derivatives: Potent and selective CRTh2 receptor antagonists by Sandham, David A., Adcock, Claire, Bala, Kamlesh, Barker, Lucy, Brown, Zarin, Dubois, Gerald, Budd, David, Cox, Brian, Fairhurst, Robin A., Furegati, Markus, Leblanc, Catherine, Manini, Jodie, Profit, Rachael, Reilly, John, Stringer, Rowan, Schmidt, Alfred, Turner, Katharine L., Watson, Simon J., Willis, Jennifer, Williams, Gareth, Wilson, Caroline

“…High throughput screening identified a 7-azaindole-3-acetic acid scaffold 7 as a novel CRTh2 receptor antagonist chemotype, which could be optimised to furnish…”
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An investigation into the structure–activity relationships associated with the systematic modification of the β2-adrenoceptor agonist indacaterol by Beattie, David, Beer, David, Bradley, Michelle E., Bruce, Ian, Charlton, Steven J., Cuenoud, Bernard M., Fairhurst, Robin A., Farr, David, Fozard, John R., Janus, Diana, Rosethorne, Elizabeth M., Sandham, David A., Sykes, David A., Trifilieff, Alexandre, Turner, Katharine L., Wissler, Elke

“…The synthesis of a series of indacaterol analogues in which each of the three structural regions of indacaterol are modified in a systematic manner is…”
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Correction to "Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP 2 Receptor Antagonist for Treatment of Asthma" by Sandham, David A, Barker, Lucy, Brown, Lyndon, Brown, Zarin, Budd, David, Charlton, Steven J, Chatterjee, Devnandan, Cox, Brian, Dubois, Gerald, Duggan, Nicholas, Hall, Edward, Hatto, Julia, Leblanc, Catherine, Maas, Janet, Manini, Jodie, Profit, Rachael, Riddy, Darren, Ritchie, Catherine, Sohal, Bindi, Shaw, Duncan, Stringer, Rowan, Sykes, David A, Thomas, Matthew, Turner, Katharine L, Watson, Simon J, West, Ryan, Willard, Elisabeth, Williams, Gareth, Willis, Jennifer

“…[This corrects the article DOI: 10.1021/acsmedchemlett.7b00157.]…”
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Correction to “Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP2 Receptor Antagonist for Treatment of Asthma” by Sandham, David A, Barker, Lucy, Brown, Lyndon, Brown, Zarin, Budd, David, Charlton, Steven J, Chatterjee, Devnandan, Cox, Brian, Dubois, Gerald, Duggan, Nicholas, Hall, Edward, Hatto, Julia, Maas, Janet, Manini, Jodie, Profit, Rachael, Riddy, Darren, Ritchie, Catherine, Sohal, Bindi, Shaw, Duncan, Stringer, Rowan, Sykes, David A, Thomas, Matthew, Turner, Katharine L, Watson, Simon J, West, Ryan, Willard, Elisabeth, Williams, Gareth, Willis, Jennifer

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Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP 2 Receptor Antagonist for Treatment of Asthma by Sandham, David A, Barker, Lucy, Brown, Lyndon, Brown, Zarin, Budd, David, Charlton, Steven J, Chatterjee, Devnandan, Cox, Brian, Dubois, Gerald, Duggan, Nicholas, Hall, Edward, Hatto, Julia, Maas, Janet, Manini, Jodie, Profit, Rachael, Riddy, Darren, Ritchie, Catherine, Sohal, Bindi, Shaw, Duncan, Stringer, Rowan, Sykes, David A, Thomas, Matthew, Turner, Katharine L, Watson, Simon J, West, Ryan, Willard, Elisabeth, Williams, Gareth, Willis, Jennifer

“…Further optimization of an initial DP receptor antagonist clinical candidate NVP-QAV680 led to the discovery of a follow-up molecule…”
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2-Cycloalkyl phenoxyacetic acid CRTh2 receptor antagonists by Sandham, David A., Aldcroft, Clive, Baettig, Urs, Barker, Lucy, Beer, David, Bhalay, Gurdip, Brown, Zarin, Dubois, Gerald, Budd, David, Bidlake, Louise, Campbell, Emma, Cox, Brian, Everatt, Brian, Harrison, David, Leblanc, Catherine J., Manini, Jodie, Profit, Rachael, Stringer, Rowan, Thompson, Katy S., Turner, Katharine L., Tweed, Morris F., Walker, Christoph, Watson, Simon J., Whitebread, Steven, Willis, Jennifer, Williams, Gareth, Wilson, Caroline

“…High throughput screening identified a phenoxyacetic acid scaffold 3 as a novel CRTh2 receptor antagonist chemotype. Optimisation furnished compound 6b, which…”
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Synthesis and biological properties of novel glucocorticoid androstene C-17 furoate esters by Sandham, David A., Barker, Lucy, Beattie, David, Beer, David, Bidlake, Louise, Bentley, David, Butler, Keith D., Craig, Sarah, Farr, David, Ffoulkes-Jones, Claire, Fozard, John R., Haberthuer, Sandra, Howes, Colin, Hynx, Deborah, Jeffers, Sarah, Keller, Thomas H., Kirkham, Paul A., Maas, Janet C., Mazzoni, Lazzaro, Nicholls, Andrew, Pilgrim, Gaynor E., Schaebulin, Elisabeth, Spooner, Gillian M., Stringer, Rowan, Tranter, Pamela, Turner, Katharine L., Tweed, Morris F., Walker, Christoph, Watson, Simon J., Cuenoud, Bernard M.

“…■■■ A series of novel corticosteroid derivatives featuring C-17 furoate ester functionality have been synthesised. Profiling in vitro and in vivo has resulted…”
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An investigation into the structure-activity relationships associated with the systematic modification of the [beta]2-adrenoceptor agonist indacaterol by Beattie, David, Beer, David, Bradley, Michelle E, Bruce, Ian, Charlton, Steven J, Cuenoud, Bernard M, Fairhurst, Robin A, Farr, David, Fozard, John R, Janus, Diana, Rosethorne, Elizabeth M, Sandham, David A, Sykes, David A, Trifilieff, Alexandre, Turner, Katharine L, Wissler, Elke

“…The synthesis of a series of indacaterol analogues in which each of the three structural regions of indacaterol are modified in a systematic manner is…”
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