Lack of Evidence for an Association between Previous HEV Genotype-3 Exposure and Glomerulonephritis in General

Lack of Evidence for an Association between Previous HEV Genotype-3 Exposure and Glomerulonephritis in General

Among numerous other immune-mediated diseases, glomerulonephritis has also been suspected to be an extrahepatic manifestation of HEV infection. In this prospective study, we tested 108 patients with glomerulonephritis and 108 age- and sex-matched healthy controls at the University Hospital Hamburg E...

Full description

Saved in:
Bibliographic Details
Published in:Pathogens (Basel) Vol. 11; no. 1; p. 18
Main Authors: Pischke, Sven, Tamanaei, Sarah, Mader, Maria, Schulze Zur Wiesch, Julian, Petersen-Benz, Christine, Haddad, Munif, Addo, Marylyn M, Schmidt, Tilman, Huber, Tobias B, Krebs, Christian F, Steinmetz, Oliver M, Turner, Jan E, Hoxha, Elion, Horvatits, Thomas
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 23-12-2021
MDPI
Subjects:
Age
Bilirubin
Biopsy
Blood & organ donations
Creatinine
Exposure
extrahepatic
Genotype & phenotype
Genotypes
Glomerular filtration rate
Glomerulonephritis
Hepatitis C
hepatitis E
HEV
Immunoglobulin G
Immunology
Infections
Kidney diseases
Patients
serology
Sex
Subgroups
Transplants & implants
Urine
Viruses
HEV
hepatitis E
glomerulonephritis
extrahepatic
serology
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Among numerous other immune-mediated diseases, glomerulonephritis has also been suspected to be an extrahepatic manifestation of HEV infection. In this prospective study, we tested 108 patients with glomerulonephritis and 108 age- and sex-matched healthy controls at the University Hospital Hamburg Eppendorf, Hamburg, Germany, for anti-HEV IgG (Wantai test) as a marker for previous HEV exposure. A total of 24 patients (22%) tested positive for anti-HEV IgG. Males tended to be more frequently anti-HEV IgG positive (29%) in comparison to females (16%). However, this does not reach statistical significance ( = 0.07). Anti-HEV IgG positive patients were older in comparison to negative patients (mean 53 vs. 45 years, = 0.05). The kidney function seems to be slightly decreased in anti-HEV IgG positive patients in comparison to and anti-HEV IgG negative patients basing on creatinine ( = 0.04) and glomerular filtration rate (GFR) ( = 0.05). Slightly higher values of bilirubin could be found in IgG positive patients ( = 0.04). Anti-HEV-IgG seropositivity rate (22%) in glomerulonephritis patients, did not differ significantly in comparison to an age- and sex-matched control cohort of healthy blood donors (31/108 positive, 29%). A total of 2/2 patients with membranoproliferative glomerulonephritis (MPGN) tested anti-HEV IgG positive ( = 0.002 in comparison to glomerulonephritis patients with other subtypes). In conclusion, our findings indicate that previous HEV exposure in a region where GT3 is endemic is not associated with glomerulonephritis in general. However, the subgroup of MPGN patients should be investigated in future studies. Furthermore, future studies are needed to investigate whether the observed association between anti-HEV IgG positivity and reduced GFR in glomerulonephritis patients is HEV associated or is an age-related effect.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
These authors contributed equally.
ISSN:2076-0817
2076-0817
DOI:10.3390/pathogens11010018