Search Results - "Turner, Jacqueline"

Regulation of CD8 T‐cell signaling, metabolism, and cytotoxic activity by extracellular lysophosphatidic acid by Torres, Raul M., Turner, Jacqueline A., D'Antonio, Marc, Pelanda, Roberta, Kremer, Kimberly N.

“…Summary Lysophosphatidic acid (LPA) is an endogenous bioactive lipid that is produced extracellularly and signals to cells via cognate LPA receptors, which are…”
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Smooth Muscle Cell Notch2 Is Not Required for Atherosclerotic Plaque Formation in ApoE Null Mice by Davis-Knowlton, Jessica, Turner, Jacqueline E, Harrington, Anne, Liaw, Lucy

“…We previously identified Notch2 in smooth muscle cells (SMC) in human atherosclerosis and found that signaling via Notch2 suppressed human SMC proliferation…”
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Lysophosphatidic acid modulates CD8 T cell immunosurveillance and metabolism to impair anti-tumor immunity by Turner, Jacqueline A., Fredrickson, Malia A., D’Antonio, Marc, Katsnelson, Elizabeth, MacBeth, Morgan, Van Gulick, Robert, Chimed, Tugs-Saikhan, McCarter, Martin, D’Alessandro, Angelo, Robinson, William A., Couts, Kasey L., Pelanda, Roberta, Klarquist, Jared, Tobin, Richard P., Torres, Raul M.

“…Lysophosphatidic acid (LPA) is a bioactive lipid which increases in concentration locally and systemically across different cancer types. Yet, the exact…”
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Pathological Conversion of Mouse Perivascular Adipose Tissue by Notch Activation by Boucher, Joshua M., Ryzhova, Larisa, Harrington, Anne, Davis-Knowlton, Jessica, Turner, Jacqueline E., Cooper, Emily, Maridas, David, Ryzhov, Sergey, Rosen, Clifford J., Vary, Calvin P.H., Liaw, Lucy

“…OBJECTIVE:Perivascular adipose tissue (PVAT) surrounding arteries supports healthy vascular function. During obesity, PVAT loses its vasoprotective effect. We…”
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Assessment of post-concussion emotional symptom load using PCSS and PROMIS instruments in pediatric patients by Johnson, Gina M, Wild, Jacob T, Burgess, Jamie K, McCracken, Kristi, Malekian, Sina, Turner, Jacqueline A, King, Kiana, Kwon, Soyang, Carl, Rebecca L, LaBella, Cynthia R

“…The purpose of this study is to evaluate the utility of the Patient-Reported Outcomes Measurement Information System (PROMIS) anxiety and depressive symptom…”
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Overcoming Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutated Tumours by Paton, Emily L., Schlaepfer, Isabel R., Turner, Jacqueline A.

“…Overactivation of the mitogen-activated protein kinase (MAPK) pathway is an important driver of many human cancers. First line, FDA-approved therapies…”
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Characterization of smooth muscle cells from human atherosclerotic lesions and their responses to Notch signaling by Davis-Knowlton, Jessica, Turner, Jacqueline E., Turner, Anna, Damian-Loring, Sydney, Hagler, Nicholas, Henderson, Terry, Emery, Ivette F., Bond, Kyle, Duarte, Christine W., Vary, Calvin P.H., Eldrup-Jorgensen, Jens, Liaw, Lucy

“…Atherosclerosis is the most common cause of heart disease and stroke. The use of animal models has advanced our understanding of the molecular signaling that…”
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Authentication of M14 melanoma cell line proves misidentification of MDA‐MB‐435 breast cancer cell line by Korch, Christopher, Hall, Erin M., Dirks, Wilhelm G., Ewing, Margaret, Faries, Mark, Varella‐Garcia, Marileila, Robinson, Steven, Storts, Douglas, Turner, Jacqueline A., Wang, Ying, Burnett, Edward C., Healy, Lyn, Kniss, Douglas, Neve, Richard M., Nims, Raymond W., Reid, Yvonne A., Robinson, William A., Capes‐Davis, Amanda

“…A variety of analytical approaches have indicated that melanoma cell line UCLA‐SO‐M14 (M14) and breast carcinoma cell line MDA‐MB‐435 originate from a common…”
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BRAF fusions identified in melanomas have variable treatment responses and phenotypes by Turner, Jacqueline A., Bemis, Judson G. T., Bagby, Stacey M., Capasso, Anna, Yacob, Betelehem W., Chimed, Tugs-Saikhan, Van Gulick, Robert, Lee, Hannah, Tobin, Richard, Tentler, John J., Pitts, Todd, McCarter, Martin, Robinson, William A., Couts, Kasey L.

“…Oncogenic BRAF fusions have emerged as an alternate mechanism for BRAF activation in melanomas and other cancers. A number of BRAF fusions with different 5′…”
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Notch2 and Proteomic Signatures in Mouse Neointimal Lesion Formation by Peterson, Sarah M, Turner, Jacqueline E, Harrington, Anne, Davis-Knowlton, Jessica, Lindner, Volkhard, Gridley, Thomas, Vary, Calvin P.H, Liaw, Lucy

“…OBJECTIVE—Vascular remodeling is associated with complex molecular changes, including increased Notch2, which promotes quiescence in human smooth muscle cells…”
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Expanding the landscape of oncogenic drivers and treatment options in acral and mucosal melanomas by targeted genomic profiling by Turner, Jacqueline A., Van Gulick, Robert J., Robinson, William A., Mughal, Tariq, Tobin, Richard P., MacBeth, Morgan L., Holman, Blair, Classon, Anthony, Bagby, Stacey M., Yacob, Betelehem W., Hartman, Sarah J., Silverman, Ian, Vorwald, Victoria M., Gorden, Nicholas, Gonzalez, Rita, Gay, Laurie M., Ali, Siraj M., Benson, Adam, Miller, Vincent A., Ross, Jeffrey S., Pitts, Todd M., Rioth, Matthew J., Lewis, Karl D., Medina, Theresa, McCarter, Martin D., Gonzalez, Rene, Couts, Kasey L.

“…Despite advancements in treating cutaneous melanoma, patients with acral and mucosal (A/M) melanomas still have limited therapeutic options and poor prognoses…”
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ALK Inhibitor Response in Melanomas Expressing EML4-ALK Fusions and Alternate ALK Isoforms by Couts, Kasey L, Bemis, Judson, Turner, Jacqueline A, Bagby, Stacey M, Murphy, Danielle, Christiansen, Jason, Hintzsche, Jennifer D, Le, Anh, Pitts, Todd M, Wells, Keith, Applegate, Allison, Amato, Carol, Multani, Pratik, Chow-Maneval, Edna, Tentler, John J, Shellman, Yiqun G, Rioth, Matthew J, Tan, Aik-Choon, Gonzalez, Rene, Medina, Theresa, Doebele, Robert C, Robinson, William A

“…Oncogenic fusions occur in several types of cancer and can be effectively treated with ALK inhibitors; however, fusions and treatment response have not been…”
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Clinical and Genetic Re-Evaluation of Inherited Retinal Degeneration Pedigrees following Initial Negative Findings on Panel-Based Next Generation Sequencing by Stephenson, Kirk A J, Zhu, Julia, Dockery, Adrian, Whelan, Laura, Burke, Tomás, Turner, Jacqueline, O'Byrne, James J, Farrar, G Jane, Keegan, David J

“…Although rare, inherited retinal degenerations (IRDs) are the most common reason for blind registration in the working age population. They are highly…”
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BH3 mimetics induce apoptosis independent of DRP-1 in melanoma by Mukherjee, Nabanita, Strosnider, Andrew, Vagher, Bay, Lambert, Karoline A., Slaven, Sarah, Robinson, William A., Amato, Carol M., Couts, Kasey L., Bemis, Judson G. T., Turner, Jacqueline A., Norris, David A., Shellman, Yiqun G.

“…Despite the recent advancement in treating melanoma, options are still limited for patients without BRAF mutations or in relapse from current treatments. BH3…”
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Autoreactive Antibodies Associated with Castleman Disease Triad by Turner, Jacqueline A., Hakimi, Ali, Lee, Hannah, Schowinsky, Jeffrey T., Sippel, Jeffrey M., Siegele, Bradford J., Torres, Raul M., Robinson, William A.

“…The Castleman triad has been described in a select few patients presenting with a retroperitoneal mass, mucocutaneous pemphigus vulgaris, and bronchiolitis…”
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Target 5000: a standardized all-Ireland pathway for the diagnosis and management of inherited retinal degenerations by Stephenson, Kirk A J, Zhu, Julia, Wynne, Niamh, Dockery, Adrian, Cairns, Rebecca M, Duignan, Emma, Whelan, Laura, Malone, Conor P, Dempsey, Hilary, Collins, Karen, Routledge, Shana, Pandey, Rajiv, Crossan, Elaine, Turner, Jacqueline, O'Byrne, James J, Brady, Laura, Silvestri, Giuliana, Kenna, Paul F, Farrar, G Jane, Keegan, David J

“…Inherited retinal degenerations (IRD) are rare genetic disorders with > 300 known genetic loci, manifesting variably progressive visual dysfunction. IRDs were…”
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Rab27a Regulates Human Perivascular Adipose Progenitor Cell Differentiation by Boucher, Joshua M., Robich, Michael, Scott, S. Spencer, Yang, Xuehui, Ryzhova, Larisa, Turner, Jacqueline E., Pinz, Ilka, Liaw, Lucy

“…Purpose Perivascular adipose tissue (PVAT) surrounds blood vessels and regulates vascular tone through paracrine secretion of cytokines. During conditions…”
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Perceptions of the Home Environments of Graduate Students Raised in Poverty by Turner, Jacqueline S., Juntune, Joyce

“…Current literature has identified a growing achievement gap experienced by students raised in poverty. However, some students from poverty can defeat the odds…”
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BRAF Modulates Lipid Use and Accumulation by Turner, Jacqueline A, Paton, Emily L, Van Gulick, Robert, Stefanoni, Davide, Cendali, Francesca, Reisz, Julie, Tobin, Richard P, McCarter, Martin, D'Alessandro, Angelo, Torres, Raul M, Robinson, William A, Couts, Kasey L, Schlaepfer, Isabel R

“…There is increasing evidence that oxidative metabolism and fatty acids play an important role in BRAF-driven tumorigenesis, yet the effect of mutation and…”
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Analysis of Human Leukocyte Antigen DR Alleles, Immune-Related Adverse Events, and Survival Associated With Immune Checkpoint Inhibitor Use Among Patients With Advanced Malignant Melanoma by Akturk, Halis Kaan, Couts, Kasey L, Baschal, Erin E, Karakus, Kagan E, Van Gulick, Robert J, Turner, Jacqueline A, Pyle, Laura, Robinson, William A, Michels, Aaron W

“…Treatment with immune checkpoint inhibitors (ICIs) has increased survival in patients with advanced malignant melanoma but can be associated with a wide range…”
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