Search Results - "Turner, Gareth D"

The pathogenesis of Plasmodium falciparum malaria in humans: insights from splenic physiology by Buffet, Pierre A., Safeukui, Innocent, Deplaine, Guillaume, Brousse, Valentine, Prendki, Virginie, Thellier, Marc, Turner, Gareth D., Mercereau-Puijalon, Odile

“…Clinical manifestations of Plasmodium falciparum infection are induced by the asexual stages of the parasite that develop inside red blood cells (RBCs)…”
Get full text

Continuous Indexing of Fibrosis (CIF): improving the assessment and classification of MPN patients by Ryou, Hosuk, Sirinukunwattana, Korsuk, Aberdeen, Alan, Grindstaff, Gillian, Stolz, Bernadette J., Byrne, Helen, Harrington, Heather A., Sousos, Nikolaos, Godfrey, Anna L., Harrison, Claire N., Psaila, Bethan, Mead, Adam J., Rees, Gabrielle, Turner, Gareth D. H., Rittscher, Jens, Royston, Daniel

“…The grading of fibrosis in myeloproliferative neoplasms (MPN) is an important component of disease classification, prognostication and monitoring. However,…”
Get full text

Respiratory Manifestations of Malaria by Taylor, Walter R.J., MBBS, MD, Hanson, Josh, MBBS, Turner, Gareth D.H., BM, BCh, DPhil, White, Nicholas J., DsC, MD, Dondorp, Arjen M., MD, PhD

“…Respiratory distress develops in up to 25% of adults and 40% of children with severe falciparum malaria. Its diverse causes include respiratory compensation of…”
Get full text

Lethal Malaria: Marchiafava and Bignami Were Right by White, Nicholas J., Turner, Gareth D. H., Day, Nicholas P. J., Dondorp, Arjen M.

“…One hundred and twenty years ago, the Italian malariologists Marchiafava and Bignami proposed that the fundamental pathological process underlying lethal…”
Get full text

Type 1 Insulin-like Growth Factor Receptor Translocates to the Nucleus of Human Tumor Cells by ALEKSIC, Tamara, CHITNIS, Meenali M, PERESTENKO, Olga V, SHAN GAO, THOMAS, Peter H, TURNER, Gareth D, PROTHEROE, Andrew S, HOWARTH, Mark, MACAULAY, Valentine M

“…The type 1 insulin-like growth factor receptor (IGF-1R) is a transmembrane glycoprotein composed of two extracellular alpha subunits and two beta subunits with…”
Get full text

Human cerebral malaria and the blood–brain barrier by Medana, Isabelle M., Turner, Gareth D.H.

“…Malaria represents a continuing and major global health challenge and our understanding of how the Plasmodium parasite causes severe disease and death remains…”
Get full text

A Randomized Controlled Trial of Three- versus Five-Day Artemether-Lumefantrine Regimens for Treatment of Uncomplicated Plasmodium falciparum Malaria in Pregnancy in Africa by Onyamboko, Marie A, Hoglund, Richard M, Lee, Sue J, Kabedi, Charlie, Kayembe, Daddy, Badjanga, Benjamin B, Turner, Gareth D H, Jackson, Nikky V, Tarning, Joel, McGready, Rose, Nosten, Francois, White, Nicholas J, Day, Nicholas P J, Fanello, Caterina

“…Artemether-lumefantrine antimalarial efficacy in pregnancy could be compromised by reduced drug exposure. Population-based simulations suggested that…”
Get full text

Correction: Continuous Indexing of Fibrosis (CIF): improving the assessment and classification of MPN patients by Ryou, Hosuk, Sirinukunwattana, Korsuk, Aberdeen, Alan, Grindstaff, Gillian, Stolz, Bernadette J., Byrne, Helen, Harrington, Heather A., Sousos, Nikolaos, Godfrey, Anna L., Harrison, Claire N., Psaila, Bethan, Mead, Adam J., Rees, Gabrielle, Turner, Gareth D. H., Rittscher, Jens, Royston, Daniel

Get full text

The murine cerebral malaria phenomenon by White, Nicholas J, Turner, Gareth D.H, Medana, Isabelle M, Dondorp, Arjen M, Day, Nicholas P.J

“…P.berghei ANKA infection in CBA or CB57BL/6 mice is used widely as a murine ‘model’ of human cerebral malaria (HCM), despite markedly different…”
Get full text

Sequestration and Microvascular Congestion Are Associated With Coma in Human Cerebral Malaria by Ponsford, Mark J., Medana, Isabelle M., Prapansilp, Panote, Hien, Tran Tinh, Lee, Sue J., Dondorp, Arjen M., Esiri, Margaret M., Day, Nicholas P. J., White, Nicholas J., Turner, Gareth D. H.

“…The pathogenesis of coma in severe Plasmodium falciparum malaria remains poorly understood. Obstruction of the brain microvasculature because of sequestration…”
Get full text

Orientia tsutsugamushi in human scrub typhus eschars shows tropism for dendritic cells and monocytes rather than endothelium by Paris, Daniel H, Phetsouvanh, Rattanaphone, Tanganuchitcharnchai, Ampai, Jones, Margaret, Jenjaroen, Kemajittra, Vongsouvath, Manivanh, Ferguson, David P J, Blacksell, Stuart D, Newton, Paul N, Day, Nicholas P J, Turner, Gareth D H

“…Scrub typhus is a common and underdiagnosed cause of febrile illness in Southeast Asia, caused by infection with Orientia tsutsugamushi. Inoculation of the…”
Get full text

CD31 angiogenesis and combined expression of HIF-1α and HIF-2α are prognostic in primary clear-cell renal cell carcinoma (CC-RCC), but HIFα transcriptional products are not: implications for antiangiogenic trials and HIFα biomarker studies in primary CC-RCC by BISWAS, Swethajit, CHARLESWO RTH, Philip J. S, GATTER, Kevin C, PEZZELLA, Francesco, HARRIS, Adrian L, TURNER, Gareth D. H, LEEK, Russell, THAMBOO, Thomas P, CAPO, Leticia, TURLEY, Helen, DILDEY, Petra, PROTHEROE, Andrew, CRANSTON, David

“…Hypoxia-inducible factors, HIF-1α and HIF-2α, are expressed in the majority of clear-cell renal cell carcinoma (CC-RCC). In vitro, HIFα isoforms regulate a…”
Get full text

An intradermal inoculation model of scrub typhus in Swiss CD-1 mice demonstrates more rapid dissemination of virulent strains of Orientia tsutsugamushi by Sunyakumthorn, Piyanate, Paris, Daniel H, Chan, Teik-Chye, Jones, Margaret, Luce-Fedrow, Alison, Chattopadhyay, Suchismita, Jiang, Ju, Anantatat, Tippawan, Turner, Gareth D H, Day, Nicholas P J, Richards, Allen L

“…Scrub typhus is an important endemic disease of the Asia-Pacific region caused by Orientia tsutsugamushi. To develop an effective vaccine to prevent scrub…”
Get full text

Single cell spatial analysis reveals inflammatory foci of immature neutrophil and CD8 T cells in COVID-19 lungs by Weeratunga, Praveen, Denney, Laura, Bull, Joshua A., Repapi, Emmanouela, Sergeant, Martin, Etherington, Rachel, Vuppussetty, Chaitanya, Turner, Gareth D. H., Clelland, Colin, Woo, Jeongmin, Cross, Amy, Issa, Fadi, de Andrea, Carlos Eduardo, Melero Bermejo, Ignacio, Sims, David, McGowan, Simon, Zurke, Yasemin-Xiomara, Ahern, David J., Gamez, Eddie C., Whalley, Justin, Richards, Duncan, Klenerman, Paul, Monaco, Claudia, Udalova, Irina A., Dong, Tao, Antanaviciute, Agne, Ogg, Graham, Knight, Julian C., Byrne, Helen M., Taylor, Stephen, Ho, Ling-Pei

“…Single cell spatial interrogation of the immune-structural interactions in COVID −19 lungs is challenging, mainly because of the marked cellular infiltrate and…”
Get full text

quantitative ultrastructural study of renal pathology in fatal Plasmodium falciparum malaria by Nguansangiam, Sudarat, Day, Nicholas P.J, Hien, Tran Tinh, Mai, Nguyen Thi Hoang, Chaisri, Urai, Riganti, Mario, Dondorp, Arjen M, Lee, Sue J, Phu, Nguyen Hoan, Turner, Gareth D.H, White, Nicholas J, Ferguson, David J.P, Pongponratn, Emsri

“…To use electron microscopy to examine the role of parasitized red blood cell (PRBC) sequestration in the pathogenesis of acute renal failure in severe…”
Get full text

Selfish spermatogonial selection: evidence from an immunohistochemical screen in testes of elderly men by Lim, Jasmine, Maher, Geoffrey J, Turner, Gareth D H, Dudka-Ruszkowska, Wioleta, Taylor, Stephen, Rajpert-De Meyts, Ewa, Goriely, Anne, Wilkie, Andrew O M

“…The dominant congenital disorders Apert syndrome, achondroplasia and multiple endocrine neoplasia-caused by specific missense mutations in the FGFR2, FGFR3 and…”
Get full text

Fatal Plasmodium falciparum Malaria Causes Specific Patterns of Splenic Architectural Disorganization by Urban, Britta C, Hien, Tran T, Day, Nicholas P, Phu, Nguyen H, Roberts, Rachel, Pongponratn, Emsri, Jones, Margret, Mai, Nguyen T. H, Bethell, Delia, Turner, Gareth D. H, Ferguson, David, White, Nicholas J, Roberts, David J

“…The spleen is critical for host defense against pathogens, including Plasmodium falciparum. It has a dual role, not only removing aged or antigenically altered…”
Get full text

A clinicopathological correlation of the expression of the angiopoietin-Tie-2 receptor pathway in the brain of adults with Plasmodium falciparum malaria by Prapansilp, Panote, Medana, Isabelle, Mai, Nguyen Thi Hoan, Day, Nicholas P J, Phu, Nguyen Hoan, Yeo, Tsin W, Hien, Tran Tinh, White, Nicholas J, Anstey, Nicholas M, Turner, Gareth D H

“…Plasma angiopoietin (Ang)-2 is associated with disease severity and mortality in adults and children with falciparum malaria. However the mechanism of action…”
Get full text

The Role of Postmortem Studies in Pneumonia Etiology Research by Turner, Gareth D. H., Bunthi, Charatdao, Wonodi, Chizoba B., Morpeth, Susan C., Molyneux, Catherine S., Zaki, Sherif R., Levine, Orin S., Murdoch, David R., Scott, J. Anthony G.

“…The diagnosis of etiology in severe pneumonia remains a challenging area. Postmortem lung tissue potentially increases the sensitivity of investigations for…”
Get full text

Serial analysis of resected prostate cancer suggests up‐regulation of type 1 IGF receptor with disease progression by Turney, Benjamin W., Turner, Gareth D.H., Brewster, Simon F., Macaulay, Valentine M.

“…What’s known on the subject? and What does the study add? In a previous study of diagnostic prostate biopsies, we showed that the insulin‐like growth factor…”
Get full text