Search Results - "Turnell, A. S"

Dissection of the C-Terminal Region of E1A Redefines the Roles of CtBP and Other Cellular Targets in Oncogenic Transformation by Cohen, M J, Yousef, A F, Massimi, P, Fonseca, G J, Todorovic, B, Pelka, P, Turnell, A S, Banks, L, Mymryk, J S

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PTTG-Binding Factor (PBF) Is a Novel Regulator of the Thyroid Hormone Transporter MCT8 by Smith, V. E, Read, M. L, Turnell, A. S, Sharma, N, Lewy, G. D, Fong, J. C. W, Seed, R. I, Kwan, P, Ryan, G, Mehanna, H, Chan, S. Y, Darras, V. M, Boelaert, K, Franklyn, J. A, McCabe, C. J

“…Within the basolateral membrane of thyroid follicular epithelial cells, two transporter proteins are central to thyroid hormone (TH) biosynthesis and…”
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Adenovirus 5 E1A is responsible for increased expression of insulin receptor substrate 4 in established adenovirus 5-transformed cell lines and interacts with IRS components activating the PI3 kinase Akt signalling pathway by Shimwell, N J, Martin, A, Bruton, R K, Blackford, A N, Sedgwick, G G, Gallimore, P H, Turnell, A S, Grand, R J A

“…Using mass spectrometric analysis insulin receptor substrate 4 (IRS-4) has been identified as a novel adenovirus 5 early region 1A (Ad5E1A)-binding protein…”
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C-terminal-binding protein interacting protein binds directly to adenovirus early region 1A through its N-terminal region and conserved region 3 by BRUTON, R. K, RASTI, M, TURNELL, A. S, GRAND, R. J. A, MAPP, K. L, YOUNG, N, CARTER, R. Z, ABRAMOWICZ, I. A, SEDGWICK, G. G, ONION, D. F, SHUEN, M, MYMRYK, J. S

“…C-terminal-binding protein interacting protein (CtIP) was first isolated as a binding partner of C-terminal-binding protein (CtBP). It is considered to…”
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Elevated PTTG and PBF predicts poor patient outcome and modulates DNA damage response genes in thyroid cancer by Read, M L, Fong, J C, Modasia, B, Fletcher, A, Imruetaicharoenchoke, W, Thompson, R J, Nieto, H, Reynolds, J J, Bacon, A, Mallick, U, Hackshaw, A, Watkinson, J C, Boelaert, K, Turnell, A S, Smith, V E, McCabe, C J

“…The proto-oncogene PTTG and its binding partner PBF have been widely studied in multiple cancer types, particularly thyroid and colorectal, but their combined…”
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Regulation of the 26S proteasome by adenovirus E1A by Turnell, Andrew S., Grand, Roger J.A., Gorbea, Carlos, Zhang, Xian, Wang, Wenlan, Mymryk, Joe S., Gallimore, Phillip H.

“…We have identified the N‐terminus of adenovirus early region 1A (AdE1A) as a region that can regulate the 26S proteasome. Specifically, in vitro and in vivo…”
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Roles for the coactivators CBP and p300 and the APC C E3 ubiquitin ligase in E1A-dependent cell transformation by Turnell, A S, Mymryk, J S

“…Adenovirus early region 1A (E1A) possesses potent transforming activity when expressed in concert with activated ras or E1B genes in in vitro tissue culture…”
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Transcriptional intermediary factor 1γ binds to the anaphase-promoting complex/cyclosome and promotes mitosis by Sedgwick, G G, Townsend, K, Martin, A, Shimwell, N J, Grand, R J A, Stewart, G S, Nilsson, J, Turnell, A S

“…The anaphase-promoting complex/cyclosome (APC/C) is an ubiquitin ligase that functions during mitosis. Here we identify the transcriptional regulator,…”
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Adenovirus E1A: remodelling the host cell, a life or death experience by Gallimore, P H, Turnell, A S

“…ONCOGENE: (2001) 20, 7824-7835…”
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Consequences of disruption of the interaction between p53 and the larger adenovirus early region 1B protein in adenovirus E1 transformed human cells by HUTTON, F. G, TURNELL, A. S, GALLIMORE, P. H, GRAND, R. J. A

“…The adenovirus early region 1B (Ad E1B) genes have no transforming capability of their own but markedly increase the transformation frequency of Ad E1A…”
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Adenovirus early region 1A protein binds to mammalian SUG1-a regulatory component of the proteasome by GRAND, R. J. A, TURNELL, A. S, MASON, G. G. F, WANG, W, MILNER, A. E, MYMRYK, J. S, ROOKES, S. M, RIVETT, A. J, GALLIMORE, P. H

“…Adenovirus early region 1A (Ad E1A) is a multifunctional protein which is essential for adenovirus-mediated transformation and oncogenesis. Whilst E1A is…”
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The Replicative Capacities of Large E1B-Null Group A and Group C Adenoviruses Are Independent of Host Cell p53 Status by Turnell, A S, Grand, R J, Gallimore, P H

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Regulation of neurite outgrowth from differentiated human neuroepithelial cells: a comparison of the activities of prothrombin and thrombin by Turnell, A S, Brant, D P, Brown, G R, Finney, M, Gallimore, P H, Kirk, C J, Pagliuca, T R, Campbell, C J, Michell, R H, Grand, R J

“…The mechanism by which thrombin and prothrombin control neurite retraction was studied in Ad12E1HER10 human neuroepithelial cells. Morphological changes in…”
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The Targeting of the Proteasomal Regulatory Subunit S2 by Adenovirus E1A Causes Inhibition of Proteasomal Activity and Increased p53 Expression by Zhang, Xian, Turnell, Andrew S., Gorbea, Carlos, Mymryk, Joe S., Gallimore, Phillip H., Grand, Roger J.A.

“…Although adenovirus early region 1A (AdE1A) can modulate protein expression through its interaction with transcriptional regulators it can also influence the…”
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Cellular consequences of thrombin-receptor activation by Grand, R J, Turnell, A S, Grabham, P W

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Accumulation of p53 in response to adenovirus early region 1A sensitizes human cells to tumor necrosis factor alpha-induced apoptosis by Zhang, Xian, Hussain, Rahel, Turnell, Andrew S., Mymryk, Joe S., Gallimore, Phillip H., Grand, Roger J.A.

“…Many tumor cells are resistant to tumor necrosis factor alpha (TNFα)-induced apoptosis. Adenovirus early region 1A (AdE1A) sensitizes the otherwise resistant…”
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Levels of Inositol Metabolites within Normal Myeloid Blast Cells and Changes during their Differentiation towards Monocytes by Bunce, C. M., French, P. J., Patton, W. Nigel, Turnell, Andrew S., Scott, Sophy A., Michell, Robert Hall, Kirk, C. J., Brown, G.

“…A homogeneous population of undifferentiated myeloid blast cells was purified from human fetal liver by rosette sedimentation of erythroblasts and macrophages,…”
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Caspase-Mediated Cleavage of Adenovirus Early Region 1A Proteins by Grand, Roger J.A., Schmeiser, Katja, Gordon, Emma M., Zhang, Xian, Gallimore, Phillip H., Turnell, Andrew S.

“…Adenovirus 2 and 12 early region 1A (Ad2 and Ad12 E1A) proteins were cleaved during cisplatin-induced apoptosis of Ad-transformed rat and human cells. Cleavage…”
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Transcriptional regulation of the human glycoprotein hormone common alpha subunit gene by cAMP-response-element-binding protein (CREB)-binding protein (CBP)/p300 and p53 by Zhang, Xian, Grand, Roger J A, McCabe, Christopher J, Franklyn, Jayne A, Gallimore, Phillip H, Turnell, Andrew S

“…We have investigated the functional interactions between adenovirus early region 1A (AdE1A) protein, the co-activators cAMP-response-element-binding protein…”
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Human Cells Arrest in S Phase in Response to Adenovirus 12 E1A by Grand, Roger J.A., Ibrahim, Adrian P., Taylor, A.Malcolm R., Milner, Anne E., Gregory, Christopher D., Gallimore, Phillip H., Turnell, Andrew S.

“…It has previously been shown that following viral infection, Ad5 E1A induces cell cycle progression of quiescent rodent cells, leading to DNA synthesis and…”
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