Search Results - "Turlington, Mark L"

Targeting Selective Activation of M1 for the Treatment of Alzheimer’s Disease: Further Chemical Optimization and Pharmacological Characterization of the M1 Positive Allosteric Modulator ML169 by Tarr, James C, Turlington, Mark L, Reid, Paul R, Utley, Thomas J, Sheffler, Douglas J, Cho, Hyekyung P, Klar, Rebecca, Pancani, Tristano, Klein, Michael T, Bridges, Thomas M, Morrison, Ryan D, Blobaum, Anna L, Xiang, Zixui, Daniels, J. Scott, Niswender, Colleen M, Conn, P. Jeffrey, Wood, Michael R, Lindsley, Craig W

“…The M1 muscarinic acetylcholine receptor is thought to play an important role in memory and cognition, making it a potential target for the treatment of…”
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Total Synthesis of Stemaphylline N-Oxide and Related C9a-Epimeric Analogues by Schulte, Michael L., Turlington, Mark L., Phatak, Sharangdhar S., Harp, Joel M., Stauffer, Shaun R., Lindsley, Craig W.

“…Winning the relay: The first total synthesis of stemaphylline N‐oxide has been completed utilizing a bistandem relay ring‐closing‐metathesis (RRCM) strategy,…”
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Heterotropic activation of the midazolam hydroxylase activity of CYP3A by a positive allosteric modulator of mGlu5: in vitro to in vivo translation and potential impact on clinically relevant drug-drug interactions by Blobaum, Anna L, Bridges, Thomas M, Byers, Frank W, Turlington, Mark L, Mattmann, Margrith E, Morrison, Ryan D, Mackie, Claire, Lavreysen, Hilde, Bartolomé, José M, Macdonald, Gregor J, Steckler, Thomas, Jones, Carrie K, Niswender, Colleen M, Conn, P Jeffrey, Lindsley, Craig W, Stauffer, Shaun R, Daniels, J Scott

“…Allosteric modulation of G protein-coupled receptors has gained considerable attention in the drug discovery arena because it opens avenues to achieve greater…”
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Structural Consequences of the 1,2,3‐Triazole as an Amide Bioisostere in Analogues of the Cystic Fibrosis Drugs VX‐809 and VX‐770 by Doiron, Jake E., Le, Christina A., Bacsa, John, Breton, Gary W., Martin, Kenneth L., Aller, Stephen G., Turlington, Mark

“…Although the 1,2,3‐triazole is a commonly used amide bioisostere in medicinal chemistry, the structural implications of this replacement have not been fully…”
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Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu sub(5): In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions by Blobaum, Anna L, Bridges, Thomas M, Byers, Frank W, Turlington, Mark L, Mattmann, Margrith E, Morrison, Ryan D, Mackie, Claire, Lavreysen, Hilde, Bartolome, Jose M, MacDonald, Gregor J

“…Allosteric modulation of G protein-coupled receptors has gained considerable attention in the drug discovery arena because it opens avenues to achieve greater…”
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Targeting Selective Activation of M 1 for the Treatment of Alzheimer’s Disease: Further Chemical Optimization and Pharmacological Characterization of the M 1 Positive Allosteric Modulator ML169 by Tarr, James C., Turlington, Mark L., Reid, Paul R., Utley, Thomas J., Sheffler, Douglas J., Cho, Hyekyung P., Klar, Rebecca, Pancani, Tristano, Klein, Michael T., Bridges, Thomas M., Morrison, Ryan D., Blobaum, Anna L., Xiang, Zixui, Daniels, J. Scott, Niswender, Colleen M., Conn, P. Jeffrey, Wood, Michael R., Lindsley, Craig W.

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Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu 5 : In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions by Blobaum, Anna L., Bridges, Thomas M., Byers, Frank W., Turlington, Mark L., Mattmann, Margrith E., Morrison, Ryan D., Mackie, Claire, Lavreysen, Hilde, Bartolomé, José M., MacDonald, Gregor J., Steckler, Thomas, Jones, Carrie K., Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Stauffer, Shaun R., Daniels, J. Scott

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Targeting selective activation of M(1) for the treatment of Alzheimer's disease: further chemical optimization and pharmacological characterization of the M(1) positive allosteric modulator ML169 by Tarr, James C, Turlington, Mark L, Reid, Paul R, Utley, Thomas J, Sheffler, Douglas J, Cho, Hyekyung P, Klar, Rebecca, Pancani, Tristano, Klein, Michael T, Bridges, Thomas M, Morrison, Ryan D, Blobaum, Anna L, Xiang, Zixui, Daniels, J Scott, Niswender, Colleen M, Conn, P Jeffrey, Wood, Michael R, Lindsley, Craig W

“…The M(1) muscarinic acetylcholine receptor is thought to play an important role in memory and cognition, making it a potential target for the treatment of…”
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