Search Results - "Turlapaty, P"

Pharmacokinetics and safety of a phenytoin prodrug given IV or IM in patients by LEPPIK, I. E, BOUCHER, B. A, WILDER, B. J, MURTHY, V. S, WATRIDGE, C, GRAVES, N. M, RANGEL, R. J, RASK, C. A, TURLAPATY, P

“…ACC-9653, a prodrug of phenytoin synthesized to be water soluble, is converted to phenytoin by phosphatases. In this study, 43 patients received ACC-9653 IV or…”
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Therapeutic level of oral anticoagulation with warfarin in patients with mechanical prosthetic heart valves: review of literature and recommendations based on international normalized ratio by Stein, P D, Grandison, D, Hua, T A, Slettehaugh, P M, Henry, J W, Turlapaty, P, Kerwin, R

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Vascular responsiveness and serum biochemical parameters in alloxan diabetes mellitus by Turlapaty, P D, Lum, G, Altura, B M

“…Responses of isolated aorta and portal vein (PV) to norepinephrine (NE), angiotensin II (AII), KCl, and CaCl2 were investigated in alloxan diabetic rats. Based…”
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Safety, tolerance and pharmacokinetics of intravenous doses of the phosphate ester of 3-hydroxymethyl-5,5-diphenylhydantoin: a new prodrug of phenytoin by Gerber, N, Mays, D C, Donn, K H, Laddu, A, Guthrie, R M, Turlapaty, P, Quon, C Y, Rivenburg, W K

“…A new prodrug of phenytoin, the disodium phosphate ester of 3-hydroxymethyl-5,5-diphenylhydantoin (ACC-9653), was administered intravenously over 30 minutes to…”
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Magnesium Deficiency Produces Spasms of Coronary Arteries: Relationship to Etiology of Sudden Death Ischemic Heart Disease by Prasad D. M. V. Turlapaty, Altura, Burton M.

“…Isolated coronary arteries from dogs were incubated in Krebs-Ringer bicarbonate solution and exposed to normal, high, and low concentrations of magnesium in…”
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WITHDRAWAL OF MAGNESIUM ENHANCES CORONARY ARTERIAL SPASMS PRODUCED BY VASOACTIVE AGENTS by ALTURA, BURTON M., TURLAPATY, PRASAD D.M.V.

“…1 The influence of external magnesium ions ([Mg2+]o) on the sensitivity (i.e. EC50) and contractility (maximum response) of isolated large and small coronary…”
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Esmolol: a short-acting titratable beta-blocker in acute myocardial ischemia by Viray, R, Turlapaty, P, Laddu, A

“…Esmolol (Brevibloc) is a potent, titratable, cardioselective beta-blocker with a short elimination half-life (t1/2 = 9.2 min) and no intrinsic sympathomimetic…”
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Phenytoin prodrug: preclinical and clinical studies by Leppik, I E, Boucher, R, Wilder, B J, Murthy, V S, Rask, C A, Watridge, C, Graves, N M, Rangel, R J, Turlapaty, P

“…The currently available phenytoin (PHT) solution has many disadvantages stemming from poor aqueous solubility of PHT. A novel approach to solve the problem has…”
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ADVERSE EFFECTS OF ARTIFICIAL BUFFERS ON CONTRACTILE RESPONSES OF ARTERIAL AND VENOUS SMOOTH MUSCLE by ALTURA, B.M., ALTURA, B.T., CARELLA, A., TURLAPATY, P.D.M.V.

“…1 In vitro studies were undertaken on rat aortic strips and portal vein segments in order to determine whether or not several commonly used artificial buffers,…”
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Influence of magnesium on calcium-induced responses of atrial and vascular muscle by Turlapaty, P D, Carrier, Jr, O

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Interactions of Tris buffer and ethanol on agonist-induced responses of vascular smooth muscle and on calcium-45 uptake by Turlapaty, P D, Altura, B T, Altura, B M

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Nicardipine in severe hypertension: oral therapy following intravenous treatment by Wallin, J D, Bienvenu, G S, Cook, E, Laddu, A, Turlapaty, P, Clifton, G G

“…Nicardipine is an investigational dihydropyridine calcium-channel blocker. In the present study, 21 patients with severe hypertension were treated with oral…”
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Influence of tris on contracile responses of isolated rat aorta and portal vein by Turlapaty, P D, Altura, B T, Altura, B M

“…The influence of tris(hydroxymethyl)-aminomethane (Tris) on the spontaneous mechanical activity (SMA) and agonist-induced contractile responses of rat portal…”
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Changes of plasma renin activity and atrial natriuretic factor during intravenous nicardipine treatment of severe hypertension by Clifton, G G, Cook, M E, MacCarthy, P, Bienvenu, G, Walsh, M, Turlapaty, P, Wallin, J D

“…Intravenous nicardipine was given to 32 severe hypertensive patients in an increasing dose, titration fashion. Samples for plasma renin activity and plasma…”
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Tris(hydroxymethyl)aminomethane inhibits calcium uptake in vascular smooth muscle by Turlapaty, P D, Altura, B T, Altura, B M

“…This report demonstrates that the commonly used buffering agent Tris(hydroxymethyl)aminomethane (Tris) in concentrations of 5 and 30 mM inhibits calcium (Ca2+)…”
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Heterogeneous distribution of adrenergic receptors in coronary arteries and their influence on coronary arterial tone by Turlapaty, P D, Altura, B M

“…In-vitro experiments, using canine large (o.d. 1-2 mm) and small (o.d. 0.4-0.8mm) coronary arteries, were undertaken to determine the functional state of…”
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Effect of intracoronary nicardipine on methylergonovine-induced coronary artery spasm in patients with variant angina by Bertrand, M E, La Blanche, J M, Hudon, P, Grandy, S, Turlapaty, P, Laddu, A R

“…In a double-blind, randomized placebo controlled study, the effect of intracoronary (IC) nicardipine (0.4 mg) on methylergonovine (0.4 mg) induced coronary…”
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In vivo antitumor activity and other pharmacological properties of halitoxin obtained from the sponge Haliclona viridis by Baslow, M H, Turlapaty, P

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Sequential changes in serum glucose, triglycerides and cholesterol in aging of normal and alloxan-diabetic rats by Altura, B M, Lum, G, Turlapaty, P D, Altura, B T

“…16-week-old Wistar, alloxan diabetic rats exhibited progressive elevations in levels of serum glucose, total triglycerides, cholesterol and creatinine over a…”
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Clinical experience with perindopril in African-American hypertensive patients: a large United States community trial by Cohn, Jay N, Julius, Stevo, Neutel, Joel, Weber, Michael, Turlapaty, Prasad, Shen, Yannan, Dong, Victor, Batchelor, Alicia, Guo, Weinong, Lagast, Hjalmar

“…The prevalence of hypertension is greater in African Americans, and management of this condition presents challenges for practicing physicians. The…”
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