A hybrid multi-particle approach to range assessment-based treatment verification in particle therapy

A hybrid multi-particle approach to range assessment-based treatment verification in particle therapy

Particle therapy (PT) used for cancer treatment can spare healthy tissue and reduce treatment toxicity. However, full exploitation of the dosimetric advantages of PT is not yet possible due to range uncertainties, warranting development of range-monitoring techniques. This study proposes a novel ran...

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Bibliographic Details
Published in:Scientific reports Vol. 13; no. 1; p. 6709
Main Authors: Meric, Ilker, Alagoz, Enver, Hysing, Liv B., Kögler, Toni, Lathouwers, Danny, Lionheart, William R. B., Mattingly, John, Obhodas, Jasmina, Pausch, Guntram, Pettersen, Helge E. S., Ratliff, Hunter N., Rovituso, Marta, Schellhammer, Sonja M., Setterdahl, Lena M., Skjerdal, Kyrre, Sterpin, Edmond, Sudac, Davorin, Turko, Joseph A., Ytre-Hauge, Kristian S.
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 25-04-2023
Nature Publishing Group
Nature Portfolio
Subjects:
639/166/985
639/766/930/2735
692/700/1421/2025
692/700/1421/2109
Cancer therapies
Collaboration
Computer engineering
Diagnostic Imaging
Gamma Rays
Humanities and Social Sciences
Humans
Monte Carlo Method
Monte Carlo simulation
multidisciplinary
Neutrons
Oncology
Patients
Phantoms, Imaging
Proton Therapy - methods
Protons
Radiation therapy
Radiotherapy Dosage
Science
Science (multidisciplinary)
Sensors
Toxicity
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Summary:Particle therapy (PT) used for cancer treatment can spare healthy tissue and reduce treatment toxicity. However, full exploitation of the dosimetric advantages of PT is not yet possible due to range uncertainties, warranting development of range-monitoring techniques. This study proposes a novel range-monitoring technique introducing the yet unexplored concept of simultaneous detection and imaging of fast neutrons and prompt-gamma rays produced in beam-tissue interactions. A quasi-monolithic organic detector array is proposed, and its feasibility for detecting range shifts in the context of proton therapy is explored through Monte Carlo simulations of realistic patient models and detector resolution effects. The results indicate that range shifts of 1 mm can be detected at relatively low proton intensities ( 22.30 ( 13 ) × 10 7 protons/spot) when spatial information obtained through imaging of both particle species are used simultaneously . This study lays the foundation for multi-particle detection and imaging systems in the context of range verification in PT.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-33777-w