Search Results - "Turko, I V"

Novel effects of nitric oxide by Davis, K. L., Martin, E., Turko, I. V., Murad, F.

“…Nitric oxide (NO), a simple free radical gas, elicits a surprisingly wide range of physiological and pathophysiological effects. NO interacts with soluble…”
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Protein Nitration in Cardiovascular Diseases by Turko, Illarion V, Murad, Ferid

“…There is growing evidence that cardiovascular disease is associated with progressive changes in the production of free radicals and radical-derived reactive…”
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Transmission of conformational change from the heparin binding site to the reactive center of antithrombin by Gettins, Peter G. W, Fan, Bingqi, Crews, Brenda C, Turko, Illarion V, Olson, Steven T, Streusand, Virginia J

“…Heparin greatly increases the rates at which antithrombin inhibits target proteinases. An important part of this rate acceleration is a heparin-induced…”
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Carbohydrate isoforms of antithrombin variant N135Q with different heparin affinities by Turko, Illarion V., Fan, Bingqi, Gettins, Peter G.W.

“…We have changed one of the carbohydrate-bearing asparagine residues of human antithrombin to glutamine by site-directed mutagenesis and expressed the variant…”
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Heterogeneity of recombinant human antithrombin III expressed in baby hamster kidney cells. Effect of glycosylation differences on heparin binding and structure by Fan, B, Crews, B C, Turko, I V, Choay, J, Zettlmeissl, G, Gettins, P

“…To determine the effects of differences in glycosylation on the structure and functional properties of recombinant human antithrombin (rHAT), we have…”
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Diabetes-associated nitration of tyrosine and inactivation of succinyl-CoA:3-oxoacid CoA-transferase by Turko, I V, Marcondes, S, Murad, F

“…High levels of reactive species of nitrogen and oxygen in diabetes may cause modifications of proteins. Recently, an increase in protein tyrosine nitration was…”
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Inhibition of cyclic GMP-binding cyclic GMP-specific phosphodiesterase (Type 5) by sildenafil and related compounds by Turko, I V, Ballard, S A, Francis, S H, Corbin, J D

“…The cGMP-binding cGMP-specific phosphodiesterase (PDE5) degrades cGMP and regulates the intracellular level of cGMP in many tissues, including the smooth…”
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Nitration of Succinyl-CoA:3-Oxoacid CoA-Transferase in Rats after Endotoxin Administration by Marcondes, Sisi, Turko, Illarion V., Murad, Ferid

“…The tyrosine nitration of proteins has been observed in diverse inflammatory conditions and has been linked to the presence of reactive nitrogen species. From…”
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Cytochrome P450 27A1 Deficiency and Regional Differences in Brain Sterol Metabolism Cause Preferential Cholestanol Accumulation in the Cerebellum by Mast, Natalia, Anderson, Kyle W., Lin, Joseph B., Li, Yong, Turko, Illarion V., Tatsuoka, Curtis, Bjorkhem, Ingemar, Pikuleva, Irina A.

“…Cytochrome P450 27A1 (CYP27A1 or sterol 27-hydroxylase) is a ubiquitous, multifunctional enzyme catalyzing regio- and stereospecific hydroxylation of different…”
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Chemical modification of rabbit IgG with N-dansylaziridine. Investigation of the properties of dansylated antibodies by Pikuleva, I A, Turko, I V, Adamovich, T B, Chashchin, V L

“…To elucidate the effect of antigen binding fluorescent thiol reagent, N-dansylaziridine (DAZ), which is sensitive to the changes in the microenvironment, was…”
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Phosphorylation of phosphodiesterase‐5 by cyclic nucleotide‐dependent protein kinase alters its catalytic and allosteric cGMP‐binding activities by Corbin, Jackie D., Turko, Illarion V., Beasley, Alfreda, Francis, Sharron H.

“…In addition to its cGMP‐selective catalytic site, cGMP‐binding cGMP‐specific phosphodiesterase (PDE5) contains two allosteric cGMP‐binding sites and at least…”
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Cross-linking studies of the cholesterol hydroxylation system from bovine adrenocortical mitochondria by Turko, I V, Adamovich, T B, Kirillova, N M, Usanov, S A, Chashchin, V L

“…Cytochrome P-450SCC and adrenodoxin were cross-linked with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide. The sample containing 94% of cross-linked complex and…”
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Potential Roles of Conserved Amino Acids in the Catalytic Domain of the cGMP-binding cGMP-specific Phosphodiesterase (PDE5) by Turko, I V, Francis, S H, Corbin, J D

“…The known mammalian 3′:5′-cyclic nucleotide phosphodiesterases (PDEs) contain a conserved region located toward the carboxyl terminus, which constitutes a…”
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Binding of cGMP to both allosteric sites of cGMP-binding cGMP-specific phosphodiesterase (PDE5) is required for its phosphorylation by Turko, I V, Francis, S H, Corbin, J D

“…cGMP-binding phosphodiesterases contain two homologous allosteric cGMP-binding sites (sites a and b) that are arranged in tandem; they constitute a superfamily…”
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Cross-linking studies of steroidogenic electron transfer: covalent complex of adrenodoxin reductase with adrenodoxin by Usanov, S A, Turko, I V, Chashchin, V L, Akhrem, A A

“…Bifunctional reagents 3,3'-dithiobis(succinimidyl propionate), 1-ethyl 3-(3-dimethylaminopropyl)carbodiimide and N-succinimidyl 3-(2-pyridyldithio)propionate…”
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An Essential Aspartic Acid at Each of Two Allosteric cGMP-binding Sites of a cGMP-specific Phosphodiesterase (∗) by McAllister-Lucas, Linda M., Haik, Tamara L., Colbran, Janet L., Sonnenburg, William K., Seger, Dalia, Turko, Illarion V., Beavo, Joe A., Francis, Sharron H., Corbin, Jackie D.

“…The amino acid sequences of all known cGMP-binding phosphodiesterases (PDEs) contain internally homologous repeats (a and b) that are 80-90 residues in length…”
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Cyclic nucleotide phosphodiesterases: relating structure and function by Francis, S H, Turko, I V, Corbin, J D

“…Cyclic nucleotide phosphodiesterases (PDEs) comprise a superfamily of metallophosphohydrolases that specifically cleave the 3',5'-cyclic phosphate moiety of…”
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Studies of the Molecular Mechanism of Discrimination between cGMP and cAMP in the Allosteric Sites of the cGMP-binding cGMP-specific Phosphodiesterase (PDE5) by Turko, Illarion V., Francis, Sharron H., Corbin, Jackie D.

“…The regulatory domain of the cGMP-binding cGMP-specific 3′:5′-cyclic nucleotide phosphodiesterase (PDE5) contains two homologous segments of amino acid…”
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Hydropathic Analysis and Mutagenesis of the Catalytic Domain of the cGMP-Binding cGMP-Specific Phosphodiesterase (PDE5). cGMP versus cAMP Substrate Selectivity by Turko, Illarion V, Francis, Sharron H, Corbin, Jackie D

“…The mechanism of discrimination between cGMP and cAMP in the catalytic site of the cGMP-binding cGMP-specific phosphodiesterase (BTPDE5A1 or PDE5) has been…”
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Histidine-607 and Histidine-643 Provide Important Interactions for Metal Support of Catalysis in Phosphodiesterase-5 by Francis, Sharron H, Turko, Illarion V, Grimes, Kennard A, Corbin, Jackie D

“…Class I cyclic nucleotide phosphodiesterases (PDEs) share a catalytic domain containing 18 invariant residues. In cGMP-binding cGMP-specific PDE (PDE5), we…”
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