Serum paraoxonase activity and oxidative stress in patients with adult nephrotic syndrome

Serum paraoxonase activity and oxidative stress in patients with adult nephrotic syndrome

Abstract Objective It has been shown that low paraoxonase-1 (PON1) activity is associated with a risk of an early development of atherosclerosis. In the present study, we investigated serum paraoxonase, and arylesterase activities and oxidative stress in patients with adult nephrotic syndrome (NS)....

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Published in:Atherosclerosis Vol. 218; no. 1; pp. 243 - 246
Main Authors: Soyoral, Yasemin Usul, Aslan, Mehmet, Emre, Habib, Begenik, Huseyin, Erdur, Fatih Mehmet, Turkel, Adnan, Selek, Sahbettin, Erkoc, Reha
Format: Journal Article
Language:English
Published: Amsterdam Elsevier Ireland Ltd 01-09-2011
Elsevier
Subjects:
Adult
adults
Antioxidants - chemistry
Aryldialkylphosphatase - blood
arylesterase
Atherosclerosis
Atherosclerosis (general aspects, experimental research)
Atherosclerosis - blood
Biological and medical sciences
Biopsy
Blood and lymphatic vessels
blood serum
Carboxylic Ester Hydrolases - blood
Cardiology. Vascular system
Cardiovascular
early development
Female
Fundamental and applied biological sciences. Psychology
General aspects
Humans
Lipid hydroperoxide
Lipid Peroxides - chemistry
Male
Medical sciences
Middle Aged
Nephrotic syndrome
Nephrotic Syndrome - blood
Oxidants - chemistry
Oxidative Stress
patients
PON1 activity
Prospective Studies
proteinuria
Proteinuria - blood
risk
Sulfhydryl Compounds - chemistry
thiols
Total thiol
Vertebrates: cardiovascular system
Total thiol
Nephrotic syndrome
PON1 activity
Lipid hydroperoxide
Atherosclerosis
Glomerulonephritis
Kidney disease
Human
Oxidative stress
Thiol
Urinary system disease
Hydroperoxide
Cardiovascular disease
Vascular disease
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Summary:Abstract Objective It has been shown that low paraoxonase-1 (PON1) activity is associated with a risk of an early development of atherosclerosis. In the present study, we investigated serum paraoxonase, and arylesterase activities and oxidative stress in patients with adult nephrotic syndrome (NS). In addition, we examined the relationship between these measurements and atherosclerosis. Methods Twenty-one patients with NS and 21 healthy controls were enrolled in the study. Serum basal and salt-stimulated paraoxonase activities, arylesterase activity, lipid hydroperoxide (LOOH) and total thiol (SH) levels were measured. Results Serum basal and salt-stimulated paraoxonase activities, arylesterase activity and total SH levels were significantly lower in patients with NS than in controls ( p < 0.05, p < 0.05, p < 0.01 and p < 0.05, respectively), whereas LOOH levels were significantly higher ( p < 0.05). Serum LOOH levels were significantly correlated with total-SH levels in patients with NS ( r = −0.467; p < 0.01). Moreover, proteinuria levels were significantly correlated with serum LOOH levels ( r = 0.397; p < 0.01), whereas no correlation was found among serum paraoxonase activity, arylesterase activity and total-SH levels in NS patients ( p > 0.05). Conclusions We concluded that oxidative stress is increased, while serum PON1 activity is decreased in patients with adult NS. In addition, these results indicate that lower PON1 activity is associated with an oxidant–antioxidant imbalance that may contribute to atherosclerosis in adult patients with NS.
Bibliography:http://dx.doi.org/10.1016/j.atherosclerosis.2011.05.037
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2011.05.037