Search Results - "Turk, James R."

High sensitivity flow cytometry of membrane vesicles by Stoner, Samuel A., Duggan, Erika, Condello, Danilo, Guerrero, Abraham, Turk, James R., Narayanan, Padma K., Nolan, John P.

“…Extracellular vesicles (EVs) are attracting attention as vehicles for inter‐cellular signaling that may have value as diagnostic or therapeutic targets. EVs…”
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Non-Lethal Endotoxin Injection: A Rat Model of Hypercoagulability by Brooks, Marjory B, Turk, James R, Guerrero, Abraham, Narayanan, Padma K, Nolan, John P, Besteman, Elizabeth G, Wilson, Dennis W, Thomas, Roberta A, Fishman, Cindy E, Thompson, Karol L, Ellinger-Ziegelbauer, Heidrun, Pierson, Jennifer B, Paulman, April, Chiang, Alan Y, Schultze, Albert E

“…Systemic inflammation co-activates coagulation, which unchecked culminates in a lethal syndrome of multi-organ microvascular thrombosis known as disseminated…”
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Distribution of cardiomyocyte-selective adeno-associated virus serotype 9 vectors in swine following intracoronary and intravenous infusion by Li, Jinliang, Kelly, Shannon C, Ivey, Jan R, Thorne, Pamela K, Yamada, Kelly P, Aikawa, Tadao, Mazurek, Renata, Turk, James R, Silva, Kleiton Augusto Santos, Amin, Amira R, Tharp, Darla L, Mueller, Christina M, Thakur, Hrishikesh, Leary, Emily V, Domeier, Timothy L, Rector, R Scott, Fish, Kenneth, Cividini, Federico, Ishikawa, Kiyotake, Emter, Craig A, Kapiloff, Michael S

“…Limited reports exist regarding adeno-associated virus (AAV) biodistribution in swine. This study assessed biodistribution following antegrade intracoronary…”
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The Effects of Repeat-Dose Doxorubicin on Cardiovascular Functional Endpoints and Biomarkers in the Telemetry-Equipped Cynomolgus Monkey by Engwall, Michael J, Everds, Nancy, Turk, James R, Vargas, Hugo M

“…Doxorubicin-related heart failure has been recognized as a serious complication of cancer chemotherapy. This paper describes a cardiovascular safety…”
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Galectin-3 as a Potential Therapeutic Target in Tumors Arising from Malignant Endothelia by Johnson, Kim D., Glinskii, Olga V., Mossine, Valeri V., Turk, James R., Mawhinney, Thomas P., Anthony, Douglas C., Henry, Carolyn J., Huxley, Virginia H., Glinsky, Gennadi V., Pienta, Kenneth J., Raz, Avraham, Glinsky, Vladislav V.

“…Angiosarcoma (ASA) in humans, hemangiosarcoma (HSA) in dogs are deadly neoplastic diseases characterized by an aggressive growth of malignant cells with…”
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Synthetic Galectin-3 Inhibitor Increases Metastatic Cancer Cell Sensitivity to Taxol-Induced Apoptosis In Vitro and In Vivo by Glinsky, Vladislav V., Kiriakova, Galina, Glinskii, Olga V., Mossine, Valeri V., Mawhinney, Thomas P., Turk, James R., Glinskii, Anna B., Huxley, Virginia H., Price, Janet E., Glinsky, Gennadi V.

“…At present, there is no efficient curative therapy for cancer patients with advanced metastatic disease. Targeting of antiapoptotic molecules acting on the…”
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Exercise training regulates SOD-1 and oxidative stress in porcine aortic endothelium by Rush, James W E, Turk, James R, Laughlin, M Harold

“…Vascular oxidative stress contributes to endothelial dysfunction. Aerobic exercise training improves vascular function. The purpose of this study was to test…”
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Cloned Transgenic Swine Via In Vitro Production and Cryopreservation by Li, Rongfeng, Lai, Liangxue, Wax, David, Hao, Yanhong, Murphy, Clifton N, Rieke, August, Samuel, Melissa, Linville, Mike L, Korte, Scott W, Evans, Rhobert W, Turk, James R, Kang, Jing X, Witt, William T, Dai, Yifan, Prather, Randall S

“…Ithas been notoriously difficult to successfully cryopreserve swine embryos, a task that has been even more difficult for in vitro-produced embryos. The first…”
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Sclerostin Downregulation Globally by Naturally Occurring Genetic Variants, or Locally in Atherosclerotic Plaques, Does Not Associate With Cardiovascular Events in Humans by Holdsworth, Gill, Staley, James R, Hall, Peter, Koeverden, Ian, Vangjeli, Ciara, Okoye, Remi, Boyce, Rogely W, Turk, James R, Armstrong, Martin, Wolfreys, Alison, Pasterkamp, Gerard

“…ABSTRACT Inhibition of sclerostin increases bone formation and decreases bone resorption, leading to increased bone mass, bone mineral density, and bone…”
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Arterial endothelial function in a porcine model of early stage atherosclerotic vascular disease by Turk, James R., Henderson, Kyle K., Vanvickle, Gregory D., Watkins, Justin, Laughlin, M. Harold

“…Summary Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the United States and is projected to become the leading cause of…”
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Microvascular network remodeling in dura mater of ovariectomized pigs: role for angiopoietin-1 in estrogen-dependent control of vascular stability by Glinskii, Olga V, Abraha, Tsghe W, Turk, James R, Rubin, Leona J, Huxley, Virginia H, Glinsky, Vladislav V

“…Estrogen is a key regulator of vascular responses and angioadaptation in multiple organs and tissues, including brain. However, the consequences of a loss of…”
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Nonclinical cardiovascular safety evaluation of romosozumab, an inhibitor of sclerostin for the treatment of osteoporosis in postmenopausal women at high risk of fracture by Turk, James R., Deaton, Aimee M., Yin, Jun, Stolina, Marina, Felx, Melanie, Boyd, Gabrielle, Bienvenu, Jean-Guy, Varela, Aurore, Guillot, Martin, Holdsworth, Gill, Wolfreys, Alison, Dwyer, Denise, Kumar, Sheetal V., de Koning, Emily M., Qu, Yusheng, Engwall, Michael, Locher, Kathrin, Ward, Lucas D., Glaus, Charles, He, Yudong D., Boyce, Rogely Waite

“…Romosozumab (EVENITY™ [romosozumab-aqqg in the US]) is a humanized monoclonal antibody that inhibits sclerostin and has been approved in several countries for…”
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Endurance exercise training improves endothelium-dependent relaxation in brachial arteries from hypercholesterolemic male pigs by Woodman, Christopher R, Thompson, Mark A, Turk, James R, Laughlin, M. Harold

“…Department of Biomedical Sciences, University of Missouri, Columbia, Missouri Submitted 16 March 2005 ; accepted in final form 17 June 2005 We tested the…”
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Evidence of porcine and human endothelium activation by cancer-associated carbohydrates expressed on glycoproteins and tumour cells by Glinskii, Olga V., Turk, James R., Pienta, Kenneth J., Huxley, Virginia H., Glinsky, Vladislav V.

“…It is well established that after metastatic cancer cells escape the primary tumour and enter the circulation, their interactions with microvascular…”
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Uterine Neoplasia in 13 Cats by Miller, Margaret A, Ramos-Vara, Jose A, Dickerson, Mary F, Johnson, Gayle C, Pace, Lanny W, Kreeger, John M, Turnquist, Susan E, Turk, James R

“…Thirteen uterine tumors were diagnosed in 13 cats and accounted for 0.29% of all feline neoplasms received during a 9.6-year period. Age at diagnosis ranged…”
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Short-term exercise training increases ACh-induced relaxation and eNOS protein in porcine pulmonary arteries by Johnson, Lynelle R, Rush, James W. E, Turk, James R, Price, Elmer M, Laughlin, M. Harold

“…1  Department of Veterinary Biomedical Sciences, 2  Veterinary Diagnostic Laboratory, and 3  Dalton Cardiovascular Research Center, University of Missouri,…”
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PDGF/VEGF system activation and angiogenesis following initial post ovariectomy meningeal microvessel loss by Glinskii, Olga V., Abraha, Tsghe W., Turk, James R., Glinsky, Vladislav V., Huxley, Virginia H.

“…Recently we demonstrated that cessation of ovarian hormone production causes dramatic vascular remodeling in meningeal microvascular networks characterized by…”
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Intravascular metastatic cancer cell homotypic aggregation at the sites of primary attachment to the endothelium by GLINSKY, Vladislav V, GLINSKY, Gennadi V, GLINSKII, Olga V, HUXLEY, Virginia H, TURK, James R, MOSSINE, Valeri V, DEUTSCHER, Susan L, PIENTA, Kenneth J, QUINN, Thomas P

“…The two major theories of cancer metastasis, the seed and soil hypothesis and the mechanical trapping theory, view tumor cell adhesion to blood vessel…”
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Current Practices in Preclinical Drug Development: Gaps in Hemostasis Testing to Assess Risk of Thromboembolic Injury by Schultze, A. Eric, Walker, Dana B., Turk, James R., Tarrant, Jacqueline M., Brooks, Marjory B., Pettit, Syril D.

“…The Health and Environmental Sciences Institute Cardiac Biomarkers Working Group surveyed the pharmaceutical development community to investigate practices in…”
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An In Vitro Cynomolgus Vascular Surrogate System for Preclinical Drug Assessment and Human Translation by Cole, Banumathi K, Simmers, Michael B, Feaver, Ryan, Qualls, Jr, Charles W, Collado, M Sol, Berzin, Erica, Figler, Robert A, Pryor, Jr, Andrew W, Lawson, Mark, Mackey, Aaron, Manka, David, Wamhoff, Brian R, Turk, James R, Blackman, Brett R

“…The predictive value of animal and in vitro systems for drug development is limited, particularly for nonhuman primate studies as it is difficult to deduce the…”
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