Search Results - "Turinetto, Valentina"

Senescence in Human Mesenchymal Stem Cells: Functional Changes and Implications in Stem Cell-Based Therapy by Turinetto, Valentina, Vitale, Emanuela, Giachino, Claudia

“…Regenerative medicine is extensively interested in developing cell therapies using mesenchymal stem cells (MSCs), with applications to several aging-associated…”
Get full text

Induced Pluripotent Stem Cells: Advances in the Quest for Genetic Stability during Reprogramming Process by Turinetto, Valentina, Orlando, Luca, Giachino, Claudia

“…Evaluation of the extent and nature of induced pluripotent stem cell (iPSC) genetic instability is important for both basic research and future clinical use…”
Get full text

A New Paradigm in Cardiac Regeneration: The Mesenchymal Stem Cell Secretome by Gallina, Clara, Giachino, Claudia, Turinetto, Valentina

“…The potentialities to apply mesenchymal stem cells (MSCs) in regenerative medicine have been extensively studied over the last decades. In the cardiovascular…”
Get full text

Stem Cell Tracking with Nanoparticles for Regenerative Medicine Purposes: An Overview by Giachino, Claudia, Turinetto, Valentina, Gallina, Clara, Accomasso, Lisa

“…Accurate and noninvasive stem cell tracking is one of the most important needs in regenerative medicine to determine both stem cell destinations and final…”
Get full text

Maintenance of genomic stability in mouse embryonic stem cells: relevance in aging and disease by Giachino, Claudia, Orlando, Luca, Turinetto, Valentina

“…Recent studies have shown that mouse embryonic stem cells (mESCs) rely on a distinctive genome caretaking network. In this review, we will discuss how mESCs…”
Get full text

Fluorescent Silica Nanoparticles Improve Optical Imaging of Stem Cells Allowing Direct Discrimination between Live and Early-Stage Apoptotic Cells by Accomasso, Lisa, Rocchietti, Elisa Cibrario, Raimondo, Stefania, Catalano, Federico, Alberto, Gabriele, Giannitti, Andrea, Minieri, Valentina, Turinetto, Valentina, Orlando, Luca, Saviozzi, Silvia, Caputo, Giuseppe, Geuna, Stefano, Martra, Gianmario, Giachino, Claudia

“…Highly bright and photostable cyanine dye‐doped silica nanoparticles, IRIS Dots, are developed, which can efficiently label human mesenchymal stem cells…”
Get full text

Multiple facets of histone variant H2AX: a DNA double-strand-break marker with several biological functions by Turinetto, Valentina, Giachino, Claudia

“…In the last decade, many papers highlighted that the histone variant H2AX and its phosphorylation on Ser 139 (γH2AX) cannot be simply considered a specific DNA…”
Get full text

H2AX phosphorylation level in peripheral blood mononuclear cells as an event-free survival predictor for bladder cancer by Turinetto, Valentina, Pardini, Barbara, Allione, Alessandra, Fiorito, Giovanni, Viberti, Clara, Guarrera, Simonetta, Russo, Alessia, Anglesio, Silvia, Ruo Redda, Maria Grazia, Casetta, Giovanni, Cucchiarale, Giuseppina, Destefanis, Paolo, Oderda, Marco, Gontero, Paolo, Rolle, Luigi, Frea, Bruno, Vineis, Paolo, Sacerdote, Carlotta, Giachino, Claudia, Matullo, Giuseppe

“…Bladder cancer (BC) has a typical aetiology characterized by a multistep carcinogenesis due to environmental exposures, genetic susceptibility, and their…”
Get full text

Micro- and Macrostructured PLGA/Gelatin Scaffolds Promote Early Cardiogenic Commitment of Human Mesenchymal Stem Cells In Vitro by Giachino, Claudia, Cristallini, Caterina, Barbani, Niccoletta, Sassi, Maria Paola, Saviozzi, Silvia, Bellotti, Elena, Turinetto, Valentina, Cibrario Rocchietti, Elisa, Mortati, Leonardo, Gagliardi, Mariacristina

“…The biomaterial scaffold plays a key role in most tissue engineering strategies. Its surface properties, micropatterning, degradation, and mechanical features…”
Get full text

A rapid flow cytometry test based on histone H2AX phosphorylation for the sensitive and specific diagnosis of ataxia telangiectasia by Porcedda, Paola, Turinetto, Valentina, Brusco, Alfredo, Cavalieri, Simona, Lantelme, Erica, Orlando, Luca, Ricardi, Umberto, Amoroso, Antonio, Gregori, Dario, Giachino, Claudia

“…Ataxia telangiectasia (A‐T) is a progressive neurodegenerative disease with onset in early childhood, caused by mutations in the ATM (ataxia‐telangiectasia…”
Get full text

The cyclin-dependent kinase inhibitor 5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole induces nongenotoxic, DNA replication-independent apoptosis of normal and leukemic cells, regardless of their p53 status by Turinetto, Valentina, Porcedda, Paola, Orlando, Luca, De Marchi, Mario, Amoroso, Antonio, Giachino, Claudia

“…Current chemotherapy of human cancers focuses on the DNA damage pathway to induce a p53-mediated cellular response leading to either G1 arrest or apoptosis…”
Get full text

Involvement of MRE11A and XPA gene polymorphisms in the modulation of DNA double-strand break repair activity: A genotype–phenotype correlation study by Ricceri, Fulvio, Porcedda, Paola, Allione, Alessandra, Turinetto, Valentina, Polidoro, Silvia, Guarrera, Simonetta, Rosa, Fabio, Voglino, Floriana, Pezzotti, Annamaria, Minieri, Valentina, Accomasso, Lisa, Rocchietti, Elisa Cibrario, Orlando, Luca, Giachino, Claudia, Matullo, Giuseppe

“…► We analyzed 768 SNPs in DNA repair genes and H2AX phosphorylation levels. ► We found an association between SNPs in MRE11A and XPA with DSBR activity. ► We…”
Get full text

Impaired elimination of DNA double-strand break-containing lymphocytes in ataxia telangiectasia and Nijmegen breakage syndrome by Porcedda, Paola, Turinetto, Valentina, Lantelme, Erica, Fontanella, Enrico, Chrzanowska, Krystyna, Ragona, Riccardo, De Marchi, Mario, Delia, Domenico, Giachino, Claudia

“…The repair of DNA double-strand breaks is critical for genome integrity and tumor suppression. Here we show that following treatment with the DNA-intercalating…”
Get full text

Histone variants as emerging regulators of embryonic stem cell identity by Turinetto, Valentina, Giachino, Claudia

“…Dynamic regulation of chromatin structure is an important mechanism for balancing the pluripotency and cell fate decision in embryonic stem cells (ESCs)…”
Get full text

Persistent DNA damage‐induced premature senescence alters the functional features of human bone marrow mesenchymal stem cells by Minieri, Valentina, Saviozzi, Silvia, Gambarotta, Giovanna, Lo Iacono, Marco, Accomasso, Lisa, Cibrario Rocchietti, Elisa, Gallina, Clara, Turinetto, Valentina, Giachino, Claudia

“…Human mesenchymal stem cells (hMSCs) are adult multipotent stem cells located in various tissues, including the bone marrow. In contrast to terminally…”
Get full text

Silica nanoparticles actively engage with mesenchymal stem cells in improving acute functional cardiac integration by Popara, Jasmin, Accomasso, Lisa, Vitale, Emanuela, Gallina, Clara, Roggio, Dorotea, Iannuzzi, Ambra, Raimondo, Stefania, Rastaldo, Raffaella, Alberto, Gabriele, Catalano, Federico, Martra, Gianmario, Turinetto, Valentina, Pagliaro, Pasquale, Giachino, Claudia

“…To assess functional effects of silica nanoparticles (SiO -NPs) on human mesenchymal stem cell (hMSC) cardiac integration potential. SiO -NPs were synthesized…”
Get full text

High Basal γH2AX Levels Sustain Self-Renewal of Mouse Embryonic and Induced Pluripotent Stem Cells by Turinetto, Valentina, Orlando, Luca, Sanchez-Ripoll, Yolanda, Kumpfmueller, Benjamin, Storm, Michael P., Porcedda, Paola, Minieri, Valentina, Saviozzi, Silvia, Accomasso, Lisa, Cibrario Rocchietti, Elisa, Moorwood, Kim, Circosta, Paola, Cignetti, Alessandro, Welham, Melanie J., Giachino, Claudia

“…Phosphorylation of histone H2AX (γH2AX) is known to be the earliest indicator of DNA double‐strand breaks. Recently, it has been shown that mouse embryonic…”
Get full text

Human mesenchymal stem cells labelled with dye-loaded amorphous silica nanoparticles: long-term biosafety, stemness preservation and traceability in the beating heart by Gallina, Clara, Capelôa, Tânia, Saviozzi, Silvia, Accomasso, Lisa, Catalano, Federico, Tullio, Francesca, Martra, Gianmario, Penna, Claudia, Pagliaro, Pasquale, Turinetto, Valentina, Giachino, Claudia

“…Treatment of myocardial infarction with mesenchymal stem cells (MSCs) has proven beneficial effects in both animal and clinical studies. Engineered silica…”
Get full text

Abstract 4615: H2AX phosphorylation assays, gene expression and epigenomic profiles as markers in bladder cancer: an integrated approach by Pardini, Barbara, Allione, Alessandra, Guarrera, Simonetta, Turinetto, Valentina, Fiorito, Giovanni, Viberti, Clara, Russo, Alessia, Vineis, Paolo, Sacerdote, Carlotta, Giachino, Claudia, Matullo, Giuseppe

“…Bladder cancer (BC), which is the fourth most common malignancy among men in the Western world, has a typical aetiology characterized by a multistep…”
Get full text

Abstract 778: DNA repair capacity, chromosomal damage, methylation and gene expression levels in bladder cancer: An integrated analysis by Matullo, Giuseppe, Viberti, Clara, Pardini, Barbara, Allione, Alessandra, Guarrera, Simonetta, Turinetto, Valentina, Giachino, Claudia, Fiorito, Giovanni, Naccarati, Alessio, Russo, Alessia, Critelli, Rossana, Destefanis, Paolo, Oderda, Marco, Gontero, Paolo, Vineis, Paolo, Sacerdote, Carlotta

“…Bladder cancer (BC) is the sixth most commonly diagnosed tumor worldwide. DNA repair capacity (DRC) refers to the ability of a cell to protect the integrity of…”
Get full text