Search Results - "Turgeon, Judith L"

Single nucleus multi-omics regulatory landscape of the murine pituitary by Ruf-Zamojski, Frederique, Zhang, Zidong, Zamojski, Michel, Smith, Gregory R., Mendelev, Natalia, Liu, Hanqing, Nudelman, German, Moriwaki, Mika, Pincas, Hanna, Castanon, Rosa Gomez, Nair, Venugopalan D., Seenarine, Nitish, Amper, Mary Anne S., Zhou, Xiang, Ongaro, Luisina, Toufaily, Chirine, Schang, Gauthier, Nery, Joseph R., Bartlett, Anna, Aldridge, Andrew, Jain, Nimisha, Childs, Gwen V., Troyanskaya, Olga G., Ecker, Joseph R., Turgeon, Judith L., Welt, Corrine K., Bernard, Daniel J., Sealfon, Stuart C.

“…To provide a multi-omics resource and investigate transcriptional regulatory mechanisms, we profile the transcriptome, chromatin accessibility, and methylation…”
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Single nucleus transcriptome and chromatin accessibility of postmortem human pituitaries reveal diverse stem cell regulatory mechanisms by Zhang, Zidong, Zamojski, Michel, Smith, Gregory R., Willis, Thea L., Yianni, Val, Mendelev, Natalia, Pincas, Hanna, Seenarine, Nitish, Amper, Mary Anne S., Vasoya, Mital, Cheng, Wan Sze, Zaslavsky, Elena, Nair, Venugopalan D., Turgeon, Judith L., Bernard, Daniel J., Troyanskaya, Olga G., Andoniadou, Cynthia L., Sealfon, Stuart C., Ruf-Zamojski, Frederique

“…Despite their importance in tissue homeostasis and renewal, human pituitary stem cells (PSCs) are incompletely characterized. We describe a human single…”
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Complex Actions of Sex Steroids in Adipose Tissue, the Cardiovascular System, and Brain: Insights from Basic Science and Clinical Studies by Turgeon, Judith L, Carr, Molly C, Maki, Pauline M, Mendelsohn, Michael E, Wise, Phyllis M

“…Recent publications describing the results of the Women’s Health Initiative (WHI) and other studies reporting the impact of hormone therapy on aging women have…”
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Hormone Therapy: Physiological Complexity Belies Therapeutic Simplicity by Turgeon, Judith L., McDonnell, Donald P., Martin, Kathryn A., Wise, Phyllis M.

“…The results of the Women's Health Initiative, a study anticipated to provide definitive answers about health benefits and risks of postmenopausal hormone…”
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Outside the box signaling: Secreted factors modulate GnRH receptor-mediated gonadotropin regulation by Pincas, Hanna, Choi, Soon Gang, Wang, Qian, Jia, Jingjing, Turgeon, Judith L., Sealfon, Stuart C.

“…•The existence of a complex regulatory network of locally secreted factors has implications for physiology and pathophysiology.•Exosignaling is emerging as a…”
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Regulatory Architecture of the LβT2 Gonadotrope Cell Underlying the Response to Gonadotropin-Releasing Hormone by Ruf-Zamojski, Frederique, Fribourg, Miguel, Ge, Yongchao, Nair, Venugopalan, Pincas, Hanna, Zaslavsky, Elena, Nudelman, German, Tuminello, Stephanie J, Watanabe, Hideo, Turgeon, Judith L, Sealfon, Stuart C

“…The LβT2 mouse pituitary cell line has many characteristics of a mature gonadotrope and is a widely used model system for studying the developmental processes…”
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Cytogenetic, Genomic, and Functional Characterization of Pituitary Gonadotrope Cell Lines by Ruf-Zamojski, Frederique, Ge, Yongchao, Pincas, Hanna, Shan, Jidong, Song, Yinghui, Hines, Nika, Kelley, Kevin, Montagna, Cristina, Nair, Pranav, Toufaily, Chirine, Bernard, Daniel J, Mellon, Pamela L, Nair, Venugopalan, Turgeon, Judith L, Sealfon, Stuart C

“…Abstract LβT2 and αT3-1 are important, widely studied cell line models for the pituitary gonadotropes that were generated by targeted tumorigenesis in…”
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Differential expression and regulation of progesterone receptor isoforms in rat and mouse pituitary cells and LβT2 gonadotropes by Turgeon, Judith L, Waring, Dennis W

“…Manipulation of endogenous progesterone receptor (PR) does not produce equivalent physiological effects in mouse and rat pituitary cells. To test whether this…”
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Effects of triclocarban on intact immature male rat: augmentation of androgen action by Duleba, Antoni J, Ahmed, Mohamed I, Sun, Meng, Gao, Allen C, Villanueva, Jesus, Conley, Alan J, Turgeon, Judith L, Benirschke, Kurt, Gee, Nancy A, Chen, Jiangang, Green, Peter G, Lasley, Bill L

“…Triclocarban (TCC; 3,4,4'-trichlorocarbanilide) is an antimicrobial agent used widely in various personal hygiene products including soaps. Recently, TCC has…”
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Ca2+-Activated K+ Channels in Gonadotropin-Releasing Hormone-Stimulated Mouse Gonadotrophs by Waring, Dennis W, Turgeon, Judith L

“…GnRH receptor activation elicits release of intracellular Ca2+, which leads to secretion and also activates Ca2+-activated ion channels underlying membrane…”
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Single-cell stabilization method identifies gonadotrope transcriptional dynamics and pituitary cell type heterogeneity by Ruf-Zamojski, Frederique, Ge, Yongchao, Nair, Venugopalan, Zamojski, Michel, Pincas, Hanna, Toufaily, Chirine, Tome-Garcia, Jessica, Stoeckius, Marlon, Stephenson, William, Smith, Gregory R, Bernard, Daniel J, Tsankova, Nadejda M, Hartmann, Boris M, Fribourg, Miguel, Smibert, Peter, Swerdlow, Harold, Turgeon, Judith L, Sealfon, Stuart C

“…Abstract Immediate-early response genes (IEGs) are rapidly and transiently induced following an extracellular signal. Elucidating the IEG response patterns in…”
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Modeling and high-throughput experimental data uncover the mechanisms underlying Fshb gene sensitivity to gonadotropin-releasing hormone pulse frequency by Stern, Estee, Ruf-Zamojski, Frederique, Zalepa-King, Lisa, Pincas, Hanna, Choi, Soon Gang, Peskin, Charles S., Hayot, Fernand, Turgeon, Judith L., Sealfon, Stuart C.

“…Neuroendocrine control of reproduction by brain-secreted pulses of gonadotropin-releasing hormone (GnRH) represents a longstanding puzzle about extracellular…”
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Growth Differentiation Factor 9 (GDF9) Forms an Incoherent Feed-forward Loop Modulating Follicle-stimulating Hormone β-Subunit (FSHβ) Gene Expression by Choi, Soon Gang, Wang, Qian, Jia, Jingjing, Pincas, Hanna, Turgeon, Judith L., Sealfon, Stuart C.

“…Gonadotropin-releasing hormone (GnRH) is secreted in brief pulses from the hypothalamus and regulates follicle-stimulating hormone β-subunit (FSHβ) gene…”
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Optimized amplification and single-cell analysis identify GnRH-mediated activation of Rap1b in primary rat gonadotropes by Yuen, Tony, Choi, Soon Gang, Pincas, Hanna, Waring, Dennis W., Sealfon, Stuart C., Turgeon, Judith L.

“…► Optimized RNA amplification allowed microarray analysis of GnRH-stimulated gonadotrope-enriched primary pituitary cultures. ► rap1b is a novel early gene…”
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Estradiol Inhibition of Voltage-Activated and Gonadotropin-Releasing Hormone-Induced Currents in Mouse Gonadotrophs by Waring, Dennis W, Turgeon, Judith L

“…We report the first study of voltage-activated and GnRH-induced plasma membrane currents and their modulation by estradiol (E2) in mouse gonadotrophs. In…”
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Luteinizing Hormone Secretion from Wild-Type and Progesterone Receptor Knockout Mouse Anterior Pituitary Cells by Turgeon, Judith L., Waring, Dennis W.

“…Abstract The progesterone receptor (PR) has a central role in the hypothalamo-pituitary events culminating in the preovulatory LH surge, and mice with…”
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PR Localization and Anterior Pituitary Cell Populations in Vitro in Ovariectomized Wild-Type and PR-Knockout Mice by Turgeon, Judith L, Shyamala, G, Waring, Dennis W

“…The PR is critical for normal female reproductive function in mammals, including primates, and the PR-knockout mouse is an important model for establishing PR…”
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Androgen Modulation of Luteinizing Hormone Secretion by Female Rat Gonadotropes by Turgeon, Judith L., Waring, Dennis W.

“…Abstract In the female, androgens can have negative and positive actions in the regulation of LH, but it is not clear how they may function during the…”
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Progesterone Regulation of the Progesterone Receptor in Rat Gonadotropes by Turgeon, Judith L., Waring, Dennis W.

“…For rat pituitary cells, progesterone receptor (PR) protein localizes to gonadotropes and PR messenger RNA is induced by E2 and rapidly but transiently…”
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OR01-06 Single Nucleus Multi-omics Analysis Identifies Cellular Trajectories And Dynamic Changes In Gene Expression And Chromatin Accessibility In The Pituitary During The Mouse Estrous Cycle by Ruf-Zamojski, Frederique Murielle, Cheng, Wan Sze, Zhang, Zidong, Zamojski, Michel, Smith, Gregory R, Chen, Xi, Mendelev, Natalia, Strupinsky, Galia, Alonso, Carlos Agustín, Gambino, Luisina Ongaro, Zhou, Xiang, Brule, Emilie, Amper, Mary Anne S, Hanna, Pincas, Nair, Venugopalan D, Andoniadou, Cynthia Lilian, Turgeon, Judith L, Troyanskaya, Olga, Zaslavsky, Elena, Bernard, Daniel J, Sealfon, Stuart C

“…Disclosure: F.M. Ruf-Zamojski: None. W. Cheng: None. Z. Zhang: None. M. Zamojski: None. G.R. Smith: None. X. Chen: None. N. Mendelev: None. G. Strupinsky:…”
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