Search Results - "Turecki, Gustavo"

Suicide and suicidal behaviour by Turecki, Gustavo, Prof, Brent, David A, Prof

“…Summary Suicide is a complex public health problem of global importance. Suicidal behaviour differs between sexes, age groups, geographic regions, and…”
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The emerging role of exosomes in mental disorders by Saeedi, Saumeh, Israel, Sonia, Nagy, Corina, Turecki, Gustavo

“…Exosomes are a class of extracellular vesicles of endocytic origin, which are released by cells and are accessible in biofluids, such as saliva, urine, and…”
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Effects of the Social Environment and Stress on Glucocorticoid Receptor Gene Methylation: A Systematic Review by Turecki, Gustavo, Meaney, Michael J

“…Abstract The early-life social environment can induce stable changes that influence neurodevelopment and mental health. Research focused on early-life…”
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Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons by Nagy, Corina, Maitra, Malosree, Tanti, Arnaud, Suderman, Matthew, Théroux, Jean-Francois, Davoli, Maria Antonietta, Perlman, Kelly, Yerko, Volodymyr, Wang, Yu Chang, Tripathy, Shreejoy J., Pavlidis, Paul, Mechawar, Naguib, Ragoussis, Jiannis, Turecki, Gustavo

“…Major depressive disorder (MDD) has an enormous impact on global disease burden, affecting millions of people worldwide and ranking as a leading cause of…”
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The miRNome of Depression by Żurawek, Dariusz, Turecki, Gustavo

“…Depression is an effect of complex interactions between genetic, epigenetic and environmental factors. It is well established that stress responses are…”
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Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides by Torres-Platas, Susana G, Cruceanu, Cristiana, Chen, Gary Gang, Turecki, Gustavo, Mechawar, Naguib

“…Abstract Despite increasing evidence supporting the neuroinflammatory theory of depression, little is known about cerebral macrophages in individuals suffering…”
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Molecular adaptations of the blood–brain barrier promote stress resilience vs. depression by Dudek, Katarzyna A., Dion-Albert, Laurence, Lebel, Manon, LeClairc, Katherine, Labrecque, Simon, Tuck, Ellen, Perez, Carmen Ferrer, Golden, Sam A., Tamminga, Carol, Turecki, Gustavo, Mechawar, Naguib, Russo, Scott J., Menard, Caroline

“…Preclinical and clinical studies suggest that inflammation and vascular dysfunction contribute to the pathogenesis of major depressive disorder (MDD). Chronic…”
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Associations Between Peer Victimization and Suicidal Ideation and Suicide Attempt During Adolescence: Results From a Prospective Population-Based Birth Cohort by Geoffroy, Marie-Claude, PhD, Boivin, Michel, PhD, Arseneault, Louise, PhD, Turecki, Gustavo, MD, PhD, Vitaro, Frank, PhD, Brendgen, Mara, PhD, Renaud, Johanne, MD, FRCPC, Séguin, Jean R., PhD, Tremblay, Richard E., PhD, Côté, Sylvana M., PhD

“…Objective To test whether adolescents who are victimized by peers are at heightened risk for suicidal ideation and suicide attempt, using both cross-sectional…”
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Epigenetic mechanisms for the early environmental regulation of hippocampal glucocorticoid receptor gene expression in rodents and humans by Zhang, Tie Yuan, Labonté, Benoit, Wen, Xiang Lan, Turecki, Gustavo, Meaney, Michael J

“…Parental care influences development across mammals. In humans such influences include effects on phenotypes, such as stress reactivity, which determine…”
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The relationship between plasma serotonin and kynurenine pathway metabolite levels and the treatment response to escitalopram and desvenlafaxine by Sun, Yu, Drevets, Wayne, Turecki, Gustavo, Li, Qingqin S.

“…•Response to escitalopram was associated with higher baseline serotonin levels.•Response to escitalopram was associated with lower baseline Kyn/Trp ratio and…”
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Epigenetics and Suicidal Behavior Research Pathways by Turecki, Gustavo, MD, PhD

“…Suicide and suicidal behaviors are complex, heterogeneous phenomena that are thought to result from the interactions among distal factors increasing…”
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miR-1202 is a primate-specific and brain-enriched microRNA involved in major depression and antidepressant treatment by Lopez, Juan Pablo, Lim, Raymond, Cruceanu, Cristiana, Crapper, Liam, Fasano, Caroline, Labonte, Benoit, Maussion, Gilles, Yang, Jennie P, Yerko, Volodymyr, Vigneault, Erika, El Mestikawy, Salah, Mechawar, Naguib, Pavlidis, Paul, Turecki, Gustavo

“…Gustavo Turecki and colleagues report that miR-1202, a miRNA specific to primates, is decreased in individuals with depression and seems to be differentially…”
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Intravenous arketamine for treatment-resistant depression: open-label pilot study by Leal, Gustavo C., Bandeira, Igor D., Correia-Melo, Fernanda S., Telles, Manuela, Mello, Rodrigo P., Vieira, Flavia, Lima, Cassio S., Jesus-Nunes, Ana Paula, Guerreiro-Costa, Lívia N. F., Marback, Roberta F., Caliman-Fontes, Ana Teresa, Marques, Breno L. S., Bezerra, Marília L. O., Dias-Neto, Alberto L., Silva, Samantha S., Sampaio, Aline S., Sanacora, Gerard, Turecki, Gustavo, Loo, Colleen, Lacerda, Acioly L. T., Quarantini, Lucas C.

“…We aimed to analyze the efficacy and safety of arketamine, the R (−)-enantiomer of ketamine, for treatment-resistant depression (TRD) in humans. Open-label…”
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A Slice of the Suicidal Brain: What Have Postmortem Molecular Studies Taught Us? by Almeida, Daniel, Turecki, Gustavo

“…Suicide ranks amongst the leading causes of death worldwide. Contemporary models of suicide risk posit that suicide results from the interaction of distal and…”
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Neuron-derived extracellular vesicles enriched from plasma show altered size and miRNA cargo as a function of antidepressant drug response by Saeedi, Saumeh, Nagy, Corina, Ibrahim, Pascal, Théroux, Jean-Francois, Wakid, Marina, Fiori, Laura M., Yang, Jennie, Rotzinger, Susan, Foster, Jane A., Mechawar, Naguib, Kennedy, Sidney H., Turecki, Gustavo

“…Previous work has demonstrated that microRNAs (miRNAs) change as a function of antidepressant treatment (ADT) response. However, it is unclear how…”
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The impact of phenotypic and genetic heterogeneity on results of genome wide association studies of complex diseases by Manchia, Mirko, Cullis, Jeffrey, Turecki, Gustavo, Rouleau, Guy A, Uher, Rudolf, Alda, Martin

“…Phenotypic misclassification (between cases) has been shown to reduce the power to detect association in genetic studies. However, it is conceivable that…”
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Methylome-wide association findings for major depressive disorder overlap in blood and brain and replicate in independent brain samples by Aberg, Karolina A., Dean, Brian, Shabalin, Andrey A., Chan, Robin F., Han, Laura K. M., Zhao, Min, van Grootheest, Gerard, Xie, Lin Y., Milaneschi, Yuri, Clark, Shaunna L., Turecki, Gustavo, Penninx, Brenda W. J. H., van den Oord, Edwin J. C. G.

“…We present the first large-scale methylome-wide association studies (MWAS) for major depressive disorder (MDD) to identify sites of potential importance for…”
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Childhood trajectories of peer victimization and prediction of mental health outcomes in midadolescence: a longitudinal population-based study by Geoffroy, Marie-Claude, PhD, Boivin, Michel, PhD, Arseneault, Louise, PhD, Renaud, Johanne, MD MSc, Perret, Léa C., MSc, Turecki, Gustavo, MD PhD, Michel, Gregory, PhD, Salla, Julie, PhD, Vitaro, Frank, PhD, Brendgen, Mara, PhD, Tremblay, Richard E., PhD, Côté, Sylvana M., PhD

“…ABSTRACT BACKGROUND Exposure to peer victimization is relatively common. However, little is known about its developmental course and its effect on impairment…”
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Repression of Astrocytic Connexins in Cortical and Subcortical Brain Regions and Prefrontal Enrichment of H3K9me3 in Depression and Suicide by Nagy, Corina, Torres-Platas, Susana G., Mechawar, Naguib, Turecki, Gustavo

“…Abstract Background: Major depressive disorder has been associated with dysfunctional astrocytic networks. The underlying causes, extent, and consequences of…”
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Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking by Lepack, Ashley E, Werner, Craig T, Stewart, Andrew F, Fulton, Sasha L, Zhong, Ping, Farrelly, Lorna A, Smith, Alexander C W, Ramakrishnan, Aarthi, Lyu, Yang, Bastle, Ryan M, Martin, Jennifer A, Mitra, Swarup, O'Connor, Richard M, Wang, Zi-Jun, Molina, Henrik, Turecki, Gustavo, Shen, Li, Yan, Zhen, Calipari, Erin S, Dietz, David M, Kenny, Paul J, Maze, Ian

“…Vulnerability to relapse during periods of attempted abstinence from cocaine use is hypothesized to result from the rewiring of brain reward circuitries,…”
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