Search Results - "Turcu, Adina F."

Targeted Molecular Characterization of Aldosterone-Producing Adenomas in White Americans by Nanba, Kazutaka, Omata, Kei, Else, Tobias, Beck, Peter C C, Nanba, Aya T, Turcu, Adina F, Miller, Barbra S, Giordano, Thomas J, Tomlins, Scott A, Rainey, William E

“…Somatic mutations have been identified in more than half of aldosterone-producing adenomas (APAs) through mutation hotspot sequencing. The underlying…”
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Adrenal Steroidogenesis and Congenital Adrenal Hyperplasia by Turcu, Adina F., MD, Auchus, Richard J., MD, PhD

“…Adrenal steroidogenesis is a dynamic process, reliant on de novo synthesis from cholesterol, under the stimulation of ACTH and other regulators. The syntheses…”
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Immune Checkpoint Inhibitors and Risk of Type 1 Diabetes by Chen, Xuan, Affinati, Alison H, Lee, Yungchun, Turcu, Adina F, Henry, Norah Lynn, Schiopu, Elena, Qin, Angel, Othus, Megan, Clauw, Dan, Ramnath, Nithya, Zhao, Lili

“…Type 1 diabetes mellitus (T1DM) is a rare, irreversible immune-related adverse event reported in patients receiving treatment with immune checkpoint inhibitors…”
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Sex Differences in 11-Oxygenated Androgen Patterns Across Adulthood by Davio, Angela, Woolcock, Helen, Nanba, Aya T, Rege, Juilee, O’Day, Patrick, Ren, Jianwei, Zhao, Lili, Ebina, Hiroki, Auchus, Richard, Rainey, William E, Turcu, Adina F

“…Abstract Context The gonads are the major source of sex steroids during reproductive ages. The gonadal function declines abruptly in women and gradually in…”
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Three Discrete Patterns of Primary Aldosteronism Lateralization in Response to Cosyntropin during Adrenal Vein Sampling by Wannachalee, Taweesak, Zhao, Lili, Nanba, Kazutaka, Nanba, Aya T, Shields, James J, Rainey, William E, Auchus, Richard J, Turcu, Adina F

“…Cosyntropin [ACTH (1-24)] stimulation during adrenal vein (AV) sampling (AVS) enhances the confidence in the success of AV cannulation and circumvents…”
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The Rise, Fall, and Resurrection of 11-Oxygenated Androgens in Human Physiology and Disease by Turcu, Adina F, Nanba, Aya T, Auchus, Richard J

“…The 11-oxyandrogens, particularly 11-ketotestosterone, have been recognized as a biologically important gonadal androgen in teleost (bony) fishes for decades,…”
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Clinical significance of 11-oxygenated androgens by Turcu, Adina F, Auchus, Richard J

“…The adrenal gland is considered a source of weak androgens, such as dehydroepiandrosterone, dehydroepiandrosterone sulfate, and androstenedione. Emerging…”
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Adrenal disorders in pregnancy by Turcu, Adina F., Lacroix, André

“…Progress in our understanding of adrenal disorders affecting pregnant women has been hindered by three major hurdles: the phenotypical and biochemical overlap…”
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Adrenal-derived 11-oxygenated 19-carbon steroids are the dominant androgens in classic 21-hydroxylase deficiency by Turcu, Adina F, Nanba, Aya T, Chomic, Robert, Upadhyay, Sunil K, Giordano, Thomas J, Shields, James J, Merke, Deborah P, Rainey, William E, Auchus, Richard J

“…Abstract Objective To comprehensively characterize androgens and androgen precursors in classic 21-hydroxylase deficiency (21OHD) and to gain insights into the…”
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Primary Aldosteronism Decreases Insulin Secretion and Increases Insulin Clearance in Humans by Adler, Gail K., Murray, Gillian R., Turcu, Adina F., Nian, Hui, Yu, Chang, Solorzano, Carmen C., Manning, Robert, Peng, Dungeng, Luther, James M.

“…Primary aldosteronism is a frequent cause of resistant hypertension and is associated with an increased risk of developing diabetes mellitus. Aldosterone…”
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Real-World Effectiveness of Mineralocorticoid Receptor Antagonists in Primary Aldosteronism by Tezuka, Yuta, Turcu, Adina F

“…To investigate how often target renin is pursued and achieved in patients with primary aldosteronism (PA) and other low renin hypertension (LRH) treated with…”
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Discordance between imaging and immunohistochemistry in unilateral primary aldosteronism by Nanba, Aya T., Nanba, Kazutaka, Byrd, James B., Shields, James J., Giordano, Thomas J., Miller, Barbara S., Rainey, William E., Auchus, Richard J., Turcu, Adina F.

“…Summary Objective Correct subtyping of primary aldosteronism (PA) is essential for good surgical outcomes. Adrenal vein sampling (AVS) and/or computed…”
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The next 150 years of congenital adrenal hyperplasia by Turcu, Adina F., Auchus, Richard J.

“…[Display omitted] •Better steroid biomarkes might improve diagnosis and management of CAH.•Improved treatments might allow good control of CAH with low…”
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Adrenal Vein Sampling Lateralization Despite Mineralocorticoid Receptor Antagonists Exposure in Primary Aldosteronism by Nanba, Aya T, Wannachalee, Taweesak, Shields, James J, Byrd, James B, Rainey, William E, Auchus, Richard J, Turcu, Adina F

“…Abstract Context Many antihypertensive medications modulate the renin-angiotensin-aldosterone system, possibly skewing the diagnosis and subtyping of primary…”
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Comprehensive Analysis of Steroid Biomarkers for Guiding Primary Aldosteronism Subtyping by Turcu, Adina F., Wannachalee, Taweesak, Tsodikov, Alexander, Nanba, Aya T., Ren, Jianwei, Shields, James J., O’Day, Patrick J., Giacherio, Donald, Rainey, William E., Auchus, Richard J.

“…Adrenal vein sampling (AVS) is required to distinguish unilateral from bilateral aldosterone sources in primary aldosteronism (PA), and cortisol is used for…”
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Circulating 11-oxygenated androgens across species by Rege, Juilee, Garber, Scott, Conley, Alan J., Elsey, Ruth M., Turcu, Adina F., Auchus, Richard J., Rainey, William E.

“…•11-oxygenated androgens, as well as DHEA and DHEAS were quantified using LC–MS/MS in 18 animal species.•The serum concentration of DHEA and DHEAS in sexually…”
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ACTH Stimulation Maximizes the Accuracy of Peripheral Steroid Profiling in Primary Aldosteronism Subtyping by Tezuka, Yuta, Ishii, Kae, Zhao, Lili, Yamazaki, Yuto, Morimoto, Ryo, Sasano, Hironobu, Udager, Aaron M, Satoh, Fumitoshi, Turcu, Adina F

“…Abstract Context Adrenocorticotropic hormone (ACTH) can contribute to aldosterone excess in primary aldosteronism (PA) via increased melanocortin type 2…”
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Targeted Mutational Analysis of Cortisol-Producing Adenomas by Rege, Juilee, Hoxie, Jessie, Liu, Chia-Jen, Cash, Morgan N, Luther, James M, Gellert, Lan, Turcu, Adina F, Else, Tobias, Giordano, Thomas J, Udager, Aaron M, Rainey, William E, Nanba, Kazutaka

“…Somatic gene mutations have been identified in only about half of cortisol-producing adenomas (CPAs). Affected genes include PRKACA, GNAS, PRKAR1A, and CTNNB1…”
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Primary Aldosteronism Screening Rates Differ with Sex, Race, and Comorbidities by Turcu, Adina F, Nhan, Winnie, Grigoryan, Seda, Zhang, Lei, Urban, Caitlin, Liu, Haiping, Holevinski, Lynn, Zhao, Lili

“…Background Primary aldosteronism (PA) is a common but under-recognized cause of secondary hypertension. Data directly comparing screening rates across single…”
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Profiles of 21-Carbon Steroids in 21-hydroxylase Deficiency by Turcu, Adina F, Rege, Juilee, Chomic, Robert, Liu, Jiayan, Nishimoto, Hiromi K, Else, Tobias, Moraitis, Andreas G, Palapattu, Ganesh S, Rainey, William E, Auchus, Richard J

“…Context: Marked elevations of 17-hydroxyprogesterone (17OHP) are characteristic of classic 21-hydroxylase deficiency (21OHD). Testing of 17OHP provides the…”
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