Search Results - "Turcotte, Sandra"

Targeting cancer cells through autophagy for anticancer therapy by Turcotte, Sandra, Giaccia, Amato J

“…Autophagy is a cellular degradation process in which portions of the cell's cytoplasm and organelles are sequestered in a double-membrane bound vesicle called…”
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Targeting lysosome function causes selective cytotoxicity in VHL-inactivated renal cell carcinomas by Bouhamdani, Nadia, Comeau, Dominique, Coholan, Alexandre, Cormier, Kevin, Turcotte, Sandra

“…Abstract The inactivation of the tumor suppressor gene, von Hippel-Lindau (VHL), has been identified as the earliest event in renal cell carcinoma (RCC)…”
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A Compendium of Information on the Lysosome by Bouhamdani, Nadia, Comeau, Dominique, Turcotte, Sandra

“…For a long time, lysosomes were considered as mere waste bags for cellular constituents. Thankfully, studies carried out in the past 15 years were brimming…”
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Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality by Chan, Denise A, Sutphin, Patrick D, Nguyen, Phuong, Turcotte, Sandra, Lai, Edwin W, Banh, Alice, Reynolds, Gloria E, Chi, Jen-Tsan, Wu, Jason, Solow-Cordero, David E, Bonnet, Muriel, Flanagan, Jack U, Bouley, Donna M, Graves, Edward E, Denny, William A, Hay, Michael P, Giaccia, Amato J

“…Identifying new targeted therapies that kill tumor cells while sparing normal tissue is a major challenge of cancer research. Using a high-throughput chemical…”
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Decrease of Intracellular Glutamine by STF-62247 Results in the Accumulation of Lipid Droplets in von Hippel-Lindau Deficient Cells by Johnson, Mathieu, Nowlan, Sarah, Sahin, Gülsüm, Barnett, David A, Joy, Andrew P, Touaibia, Mohamed, Cuperlovic-Culf, Miroslava, Zofija Avizonis, Daina, Turcotte, Sandra

“…Kidney cancer is one of the top ten cancer diagnosed worldwide and its incidence has increased the last 20 years. Clear Cell Renal Cell Carcinoma (ccRCC) are…”
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Hypoxia Promotes Murine Bone‐Marrow‐Derived Stromal Cell Migration and Tube Formation by Annabi, Borhane, Lee, Ying‐Ta, Turcotte, Sandra, Naud, Emmanuelle, Desrosiers, Richard R., Champagne, Martin, Eliopoulos, Nicoletta, Galipeau, Jacques, Béliveau, Richard

“…Recent evidence indicates that bone‐marrow‐derived stromal cells (MSCs) have a histology coherent with endothelial cells that may enable them to contribute to…”
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Synthesis, Characterization, and Anticancer Activities of Pyrogallol-Based Arylspiroborates by Cormier, Kevin, Curry, R. Daniel, Betsch, Mitchel P., Goguen, Jeremy A., Vogels, Christopher M., Decken, Andreas, Turcotte, Sandra, Westcott, Stephen A.

“…Arylspiroborate salts derived from pyrogallol, gallic acid, and propyl gallate have been prepared and characterized fully, including an X‐ray diffraction study…”
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Targeted therapy for the loss of von Hippel-Lindau in renal cell carcinoma: A novel molecule that induces autophagic cell death by Turcotte, Sandra, Sutphin, Patrick D., Giaccia, Amato J.

“…Radiation and conventional cytotoxic chemotherapies are ineffective in treating renal cancer. Approximately 75% of renal cell carcinoma (RCC) is associated…”
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Abstract 3956: Identifying PIKfyve as potential target in clear cell renal cell carcinoma with a loss of the von Hippel-Lindau tumor suppressor gene by Bouhamdani, Nadia, Turcotte, Sandra

“…Abstract Background. Clear cell renal cell carcinoma (ccRCC) is the most frequent type of cancer in the kidney. These tumors are highly vascular and correlate…”
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Abstract 2599: Targeting SETD2-inactivated cells with STF-62247 leads to cell cycle arrest by Johnson, Mathieu, Turcotte, Sandra

“…Abstract The SETD2 gene encodes a histone methyltransferase responsible for the trimethylation of histone 3 on lysine 36 (H3K36me3). While this canonic…”
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Abstract 1379: Studying the autophagic flux in response to hypoxia in BAP1-mutated pleural mesothelioma cells linked to asbestos exposure by Michaud, Chloe, Turcotte, Sandra

“…Abstract Introduction. Malignant mesothelioma is a rare cancer linked to asbestos exposure. It comes from the oncogenic transformation of mesothelioma cells, a…”
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Abstract 3617: Investigating a role for PIKfyve in cell migration and invasion of clear cell renal cell carcinoma by Cormier, Jolène, Turcotte, Sandra

“…Abstract Introduction. Clear cell renal cell carcinoma (ccRCC) is the most frequent type of kidney cancer. These highly vascularized tumors are characterized…”
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STF-62247 accumulates in lysosomes and blocks late stages of autophagy to selectively target von Hippel-Lindau-inactivated cells by Bouhamdani, Nadia, Comeau, Dominique, Cormier, Kevin, Turcotte, Sandra

“…Autophagy is a highly conserved, homeostatic process by which cytosolic components reach lysosomes for degradation. The roles played by different autophagic…”
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(1)H NMR metabolomics analysis of renal cell carcinoma cells: Effect of VHL inactivation on metabolism by Cuperlovic-Culf, Miroslava, Cormier, Kevin, Touaibia, Mohamed, Reyjal, Julie, Robichaud, Sarah, Belbraouet, Mehdi, Turcotte, Sandra

“…Von Hippel-Lindau (VHL) is an onco-suppressor involved in oxygen and energy-dependent promotion of protein ubiquitination and proteosomal degradation. Loss of…”
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Autophagy and cell death to target cancer cells: exploiting synthetic lethality as cancer therapies by Reyjal, Julie, Cormier, Kevin, Turcotte, Sandra

“…Since 1940 chemotherapy has been one of the major therapies used to kill cancer cells. However, conventional standard cytotoxic agents have a low therapeutic…”
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Discovery of a novel 2,5-dihydroxycinnamic acid-based 5-lipoxygenase inhibitor that induces apoptosis and may impair autophagic flux in RCC4 renal cancer cells by Selka, Ayyoub, Doiron, Jérémie A., Lyons, Pierre, Dastous, Sonia, Chiasson, Alison, Cormier, Marc, Turcotte, Sandra, Surette, Marc E., Touaibia, Mohamed

“…The inhibition of 5-lipoxygenase (5-LO), the key enzyme for the biosynthesis of leukotrienes (LTs), has generated increasing enthusiasm as anti-inflammatory…”
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Abstract 3787: miR 2355-5p regulates tumor growth and angiogenesis in VHL-inactivated clear cell renal cell carcinoma by Page, Patric, Turcotte, Sandra, Martin, Mykella, Richard, Patrick, Nishimura, Tamiko, Riazalhosseini, Yasser

“…Abstract Background: Clear Cell Renal Cell Carcinoma (ccRCC) constitutes more than 75% of kidney cancer diagnostics. Inactivation of the tumor suppressor gene…”
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A Molecule Targeting VHL-Deficient Renal Cell Carcinoma that Induces Autophagy by Turcotte, Sandra, Chan, Denise A., Sutphin, Patrick D., Hay, Michael P., Denny, William A., Giaccia, Amato J.

“…Renal cell carcinomas (RCCs) are refractory to standard therapies. The von Hippel-Lindau (VHL) tumor suppressor gene is inactivated in 75% of RCCs. By…”
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Quantitative proteomics to study a small molecule targeting the loss of von Hippel–Lindau in renal cell carcinomas by Bouhamdani, Nadia, Joy, Andrew, Barnett, David, Cormier, Kevin, Léger, Daniel, Chute, Ian C., Lamarre, Simon, Ouellette, Rodney, Turcotte, Sandra

“…Inactivation of the tumor suppressor gene, von Hippel–Lindau (VHL), is known to play an important role in the development of sporadic clear cell renal cell…”
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1 H NMR metabolomics analysis of renal cell carcinoma cells: Effect of VHL inactivation on metabolism by Cuperlovic‐Culf, Miroslava, Cormier, Kevin, Touaibia, Mohamed, Reyjal, Julie, Robichaud, Sarah, Belbraouet, Mehdi, Turcotte, Sandra

“…Von Hippel‐Lindau ( VHL ) is an onco‐suppressor involved in oxygen and energy‐dependent promotion of protein ubiquitination and proteosomal degradation. Loss…”
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