Search Results - "Tuominen, R K"

Carcinogenicity of the Drinking Water Mutagen 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone in the Rat by Komulainen, Hannu, Vaittinen, Sirkka-Liisa, Vartiainen, Terttu, Tuomisto, Jouko, Kosma, Veli-Matti, Kaliste-Korhonen, Eila, Lötjönen, Simo, K. Tuominen, Raimo

“…Background: Several epidemiologic studies have suggested that the consumption of chlorinated drinking water may be associated with the development of certain…”
Get full text

Medium-throughput computer aided micro-island method to assay embryonic dopaminergic neuron cultures in vitro by Planken, A., Porokuokka, L.L., Hänninen, A.-L., Tuominen, R.K., Andressoo, J.-O.

“…▶ Cost and time effective assessment of dopaminergic effects of neurotrophic factors and small molecules. ▶ Improved statistical power. ▶ Enables 10 data…”
Get full text

Protein kinase C -activating isophthalate derivatives mitigate Alzheimer's disease-related cellular alterations by Sarajärvi, T., Jäntti, M., Paldanius, K.M.A., Natunen, T., Wu, J.C., Mäkinen, P., Tarvainen, I., Tuominen, R.K., Talman, V., Hiltunen, M.

“…Abnormal protein kinase C (PKC) function contributes to many pathophysiological processes relevant for Alzheimer's disease (AD), such as amyloid precursor…”
Get full text

Protein kinase C expression in salivary gland acinar epithelial cells in Sjögren's syndrome by Törnwall, J, Konttinen, Y T, Tuominen, R K, Törnwall, M

Get more information

Labelling, molecular modelling and biological evaluation of vardenafil: a potential agent for diagnostic evaluation of erectile dysfunction by El-Kawy, O.A., García-Horsman, J.A., Tuominen, R.K.

“…99mTc–tricarbonyl–vardenafil was specifically radiosynthesized for diagnostic evaluation of erectile dysfunction with a radiochemical yield ~97.2%. It was…”
Get full text

Different in vivo properties of three new inhibitors of catechol O‐methyltransferase in the rat by Männistö, Pekka T., Tuomainen, Päivi, Tuominen, Raimo K.

“…1 We compared three new catechol O‐methyltransferase (COMT) inhibitors (OR‐611, Ro 40–7592 and CGP 28014; 10 and 30 mg kg−1, i.p.) in male rats given levodopa…”
Get full text

Hydrogen peroxide attenuates store-operated calcium entry and enhances calcium extrusion in thyroid FRTL-5 cells by Törnquist, K, Vainio, P J, Björklund, S, Titievsky, A, Dugué, B, Tuominen, R K

“…Redox modulation participates in the regulation of intracellular free calcium concentration ([Ca(2+)](i)) in several cell types. In thyroid cells, including…”
Get full text

Cotinine and Nicotine Inhibit Each Other's Calcium Responses in Bovine Chromaffin Cells by Vainio, Petri J., Törnquist, Kid, Tuominen, Raimo K.

“…Cotinine is the major metabolite of nicotine. It has some biological activity, but its pathophysiological effects are largely unclear. We studied whether…”
Get full text

Role of Protein Kinase C in Microglia-induced Neurotoxicity in Mesencephalic Cultures by MCMILLIAN, MICHAEL K, VAINIO, PETRI J, TUOMINEN, RAIMO K

“…Microglial activation selectively kills certain neuron populations in mixed neuronal/glial cultures, which may prove useful for modeling neurodegenerative…”
Get full text

Cytotoxicity of macrolide antibiotics in a cultured human liver cell line by Viluksela, Matti, Vainio, Petri J., Tuominen, Raimo K.

“…Cytotoxicity of erythromycin base, erythromycin estolate, erythromycin-11,12-cyclic carbonate, roxithromycin, clarithromycin and azithromycin was compared in…”
Get full text

Effect of repeated L-histidine administration on plasma prolactin and growth hormone levels in rats by Lozeva, V, Tuominen, R K, Männistö, P T, Tuomisto, L

Get full text

Effects of Catechol-O-Methyltransferase Deficiency on the Reinforcing Effects of Cocaine (an experimental study) by Mus, L. V., Dravolina, O. A., Bespalov, A. Yu, Käenmäki, M., Talka, R., Salminen, O., Tuominen, R. K., Männistö, P. T., Zvartau, E. E.

“…The effects of catechol-O-methyltransferase deficiency on sensitivity to the reinforcing action of cocaine were studied in male C57BL/6J mice with knockout of…”
Get full text

Angiotensin II receptors are coupled to omega-conotoxin-sensitive calcium influx in bovine adrenal medullary chromaffin cells by McMillian, M K, Tuominen, R K, Hudson, P M, Suh, H H, Hong, J S

“…The contribution of an omega-conotoxin GVIA (omega Cgtx)-sensitive Ca2+ influx pathway to the effects of angiotensin II (AII) receptor activation was examined…”
Get more information

Cold exposure attenuates effects of secretagogues on serum prolactin and growth hormone levels in male rats by Rauhala, P, Idänpään-Heikkilä, J J, Lang, A, Tuominen, R K, Männistö, P T

“…The stimulatory effect of morphine, dexmedetomidine (an alpha 2-adrenoceptor agonist), 1-(3-chlorophenyl)-piperazine (m-CPP, a 5-HT1B agonist), U-50488H (a…”
Get full text

Short and long term regulation of catecholamine biosynthetic enzymes by angiotensin in cultured adrenal medullary cells. Molecular mechanisms and nature of second messenger systems by Stachowiak, M K, Jiang, H K, Poisner, A M, Tuominen, R K, Hong, J S

“…The purpose of this study was to examine the effects of angiotensin on the enzyme activities and gene expression of two catecholamine synthesizing enzymes,…”
Get full text

Differential disappearance of tolerance to thermal, hormonal and locomotor effects of morphine in the male rat by Rauhala, Pekka, Idänpään-Heikkilä, Juhana J., Tuominen, Raimo K., Männistö, Pekka T.

“…Development and disappearance of tolerance to various effects of morphine was studied by comparing the effect of acute morphine at 6 h and at 92 h after…”
Get full text

Long-term activation of protein kinase C by nicotine in bovine adrenal chromaffin cells by Tuominen, R K, McMillian, M K, Ye, H, Stachowiak, M K, Hudson, P M, Hong, J S

“…Previous results from our laboratory suggest that long-term treatment of primary cultured bovine adrenal medullary (BAM) chromaffin cells with nicotine or…”
Get more information

Effect of Catechol-O-methyltransferase deficiency on reinforcing effects of cocaine (experimental study) by Mus, L V, Dravolina, O A, Bespalov, A Iu, Käenmäki, M, Talka, R, Salminen, O, Tuominen, R K, Männistiö, P T, Zvartau, E E

“…Catechol-O-methyltransferase (COMT) remains an important regulatory element in prefrontal cortex dopamine homeostasis. The literature data suggest that…”
Get more information

Hypothalamic histamine, growth rate, plasma prolactin and growth hormone levels in rats with long-term portacaval anastomosis by Lozeva, V, Anttila, E, Tuominen, R K, Hippeläinen, M, Männistö, P T, Tuomisto, L

“…Histamine can modulate feeding behaviour and hormone release; therefore we examined the hypothalamic histamine system, the growth pattern and the serum levels…”
Get full text

Cotinine binding to nicotinic acetylcholine receptors in bovine chromaffin cell and rat brain membranes by Vainio, Petri J., Tuominen, Raimo K.

“…Cotinine is the major metabolite of nicotine. It has nicotine-like biological activity, but its potency is low. We studied cotinine binding to nicotinic…”
Get full text