Search Results - "Tuomilehto‐Wolf, Eva"

Haplotype tagging for the identification of common disease genes by Todd, John A, Johnson, Gillian C.L, Esposito, Laura, Barratt, Bryan J, Smith, Annabel N, Heward, Joanne, Di Genova, Gianfranco, Ueda, Hironori, Cordell, Heather J, Eaves, Iain A, Dudbridge, Frank, Twells, Rebecca C.J, Payne, Felicity, Hughes, Wil, Nutland, Sarah, Stevens, Helen, Carr, Phillipa, Tuomilehto-Wolf, Eva, Tuomilehto, Jaakko, Gough, Stephen C.L, Clayton, David G

“…Genome-wide linkage disequilibrium (LD) mapping of common disease genes could be more powerful than linkage analysis if the appropriate density of polymorphic…”
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Remapping the Insulin Gene/IDDM2 Locus in Type 1 Diabetes by BARRATT, Bryan J, PAYNE, Felicity, MCCORMACK, Rose, GUJA, Cristian, IONESCU-URGOVIGTE, Constantin, UNDLIEN, Dag E, RØNNINGEN, Kjersti S, GILLESPIE, Kathleen M, TUOMILEHTO-WOLF, Eva, TUOMILEHTO, Jaakko, BENNETT, Simon T, CLAYTON, David G, LOWE, Chris E, CORDELL, Heather J, TODD, John A, HERMANN, Robert, HEALY, Barry C, HAROLD, Denise, CONCANNON, Patrick, GHARANI, Neda, MCCARTHY, Mark I, OLAVESEN, Mark G

“…Remapping the Insulin Gene/ IDDM2 Locus in Type 1 Diabetes Bryan J. Barratt 1 , Felicity Payne 1 , Chris E. Lowe 1 , Robert Hermann 1 , Barry C. Healy 1 ,…”
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Comparative high-resolution analysis of linkage disequilibrium and tag single nucleotide polymorphisms between populations in the vitamin D receptor gene by Nejentsev, Sergey, Godfrey, Lisa, Snook, Hywel, Rance, Helen, Nutland, Sarah, Walker, Neil M., Lam, Alex C., Guja, Cristian, Ionescu-Tirgoviste, Constantin, Undlien, Dag E., Rønningen, Kjersti S., Tuomilehto-Wolf, Eva, Tuomilehto, Jaakko, Newport, Melanie J., Clayton, David G., Todd, John A.

“…A genome-wide map of single nucleotide polymorphisms (SNP) and a pattern of linkage disequilibrium (LD) between their alleles are being established in three…”
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Analysis of the Vitamin D Receptor Gene Sequence Variants in Type 1 Diabetes by NEJENTSEV, Sergey, COOPER, Jason D, UNDLIEN, Dag E, RØNNINGEN, Kjersti S, TUOMILEHTO-WOLF, Eva, TUOMILEHTO, Jaakko, GILLESPIE, Kathleen M, RING, Susan M, STRACHAN, David P, WIDMER, Barry, DUNGER, David, TODDL, John A, GODFREY, Lisa, HOWSON, Joanna M. M, RANCE, Helen, NUTLAND, Sarah, WALKER, Neil M, GUJA, Cristian, IONESCU-TIRGOVISTE, Constantin, SAVAGE, David A

“…Analysis of the Vitamin D Receptor Gene Sequence Variants in Type 1 Diabetes Sergey Nejentsev , Jason D. Cooper 1 , Lisa Godfrey 1 , Joanna M.M. Howson 1 ,…”
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Full likelihood analysis of genetic risk with variable age at onset disease--combining population-based registry data and demographic information by Pitkäniemi, Janne, Varvio, Sirkka-Liisa, Corander, Jukka, Lehti, Nella, Partanen, Jukka, Tuomilehto-Wolf, Eva, Tuomilehto, Jaakko, Thomas, Andrew, Arjas, Elja

“…In genetic studies of rare complex diseases it is common to ascertain familial data from population based registries through all incident cases diagnosed…”
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Analysis of the Type 2 Diabetes-Associated Single Nucleotide Polymorphisms in the Genes IRS1, KCNJ11, and PPARG2 in Type 1 Diabetes by EFTYCHI, Christina, HOWSON, Joanna M. M, TUOMILEHTO, Jaakko, UNDLIEN, Dag E, RØNNINGEN, Kjersti S, GUJA, Cristian, IONESCU-TIRGOVISTE, Constantin, SAVAGE, David A, TODD, John A, BARRATT, Bryan J, VELLA, Adrian, PAYNE, Felicity, SMYTH, Deborah J, TWELLS, Rebecca C. J, WALKER, Neil M, RANCE, Helen E, TUOMILEHTO-WOLF, Eva

“…Analysis of the Type 2 Diabetes-Associated Single Nucleotide Polymorphisms in the Genes IRS1 , KCNJ11 , and PPARG2 in Type 1 Diabetes Christina Eftychi 1 ,…”
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HLA and susceptibility to juvenile idiopathic arthritis: a study of affected sibpairs in an isolated Finnish population by SÄILÄ, Hanna, PITKÄNIEMI, Janne, TUOMILEHTO, Jaakko, SAVOLAINEN, Anneli, ALAKULPPI, Noora, TUOMILEHTO-WOLF, Eva, LEIRISALO-REPO, Marjatta, AHO, Kimmo

“…OBJECTIVE: To determine the effects of class I (A, B, and C) and II (DRB1 and DQB1) HLA loci alleles and DRB1-DQB1 haplotypes on genetic susceptibility to…”
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A Comprehensive, Statistically Powered Analysis of GAD2 in Type 1 Diabetes by JOHNSON, Gillian C. L, PAYNE, Felicity, NUTLAND, Sarah, STEVENS, Helen, TUOMILEHTO-WOLF, Eva, TUOMILEHTO, Jaakko, TODD, John A

“…A Comprehensive, Statistically Powered Analysis of GAD2 in Type 1 Diabetes Gillian C.L. Johnson 1 , Felicity Payne 1 , Sarah Nutland 1 , Helen Stevens 1 , Eva…”
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Association Analysis of the Lymphocyte-Specific Protein Tyrosine Kinase (LCK) Gene in Type 1 Diabetes by HULME, John S, BARRATT, Bryan J, GUJA, Cristian, IONESCU-TIRGOVISTE, Constantin, TUOMILEHTO-WOLF, Eva, TUOMILEHTO, Jaakko, TODD, John A, TWELLS, Rebecca C. J, COOPER, Jason D, LOWE, Chris E, HOWSON, Joanna M. M, LAM, Alex C, SMINK, Luc J, SAVAGE, David A, UNDLIEN, Dag E

“…Association Analysis of the Lymphocyte-Specific Protein Tyrosine Kinase (LCK) Gene in Type 1 Diabetes John S. Hulme 1 , Bryan J. Barratt 1 , Rebecca C.J…”
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Lack of Association of the Ala45Thr Polymorphism and Other Common Variants of the NeuroD Gene With Type 1 Diabetes by Vella, Adrian, Howson, Joanna M.M., Barratt, Bryan J., Twells, Rebecca C.J., Rance, Helen E., Nutland, Sarah, Tuomilehto-Wolf, Eva, Tuomilehto, Jaakko, Undlien, Dag E., Rønningen, Kjersti S., Guja, Cristian, Ionescu-Tîrgovişte, Constantin, Savage, David A., Todd, John A.

“…Lack of Association of the Ala 45 Thr Polymorphism and Other Common Variants of the NeuroD Gene With Type 1 Diabetes Adrian Vella 1 , Joanna M.M. Howson 1 ,…”
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Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease by Wicker, Linda S, Todd, John A, Ueda, Hironori, Howson, Joanna M. M, Esposito, Laura, Heward, Joanne, Snook, Chamberlain, Giselle, Rainbow, Daniel B, Hunter, Kara M. D, Smith, Annabel N, Di Genova, Gianfranco, Herr, Mathias H, Dahlman, Ingrid, Payne, Felicity, Smyth, Deborah, Lowe, Christopher, Twells, Rebecca C. J, Howlett, Sarah, Healy, Barry, Nutland, Sarah, Rance, Helen E, Everett, Vin, Smink, Luc J, Lam, Alex C, Cordell, Heather J, Walker, Neil M, Bordin, Cristina, Hulme, John, Motzo, Costantino, Cucca, Francesco, Hess, J. Fred, Metzker, Michael L, Rogers, Jane, Gregory, Simon, Allahabadia, Amit, Nithiyananthan, Ratnasingam, Tuomilehto-Wolf, Eva, Tuomilehto, Jaakko, Bingley, Polly, Gillespie, Kathleen M, Undlien, Dag E, Rønningen, Kjersti S, Guja, Cristian, Ionescu-Tîrgovi te, Constantin, Savage, David A, Maxwell, A. Peter, Carson, Dennis J, Patterson, Chris C, Franklyn, Jayne A, Clayton, David G, Peterson, Laurence B, Gough, Stephen C. L

“…Genes and mechanisms involved in common complex diseases, such as the autoimmune disorders that affect approximately 5% of the population, remain obscure. Here…”
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A genome-wide scan for type 1 diabetes susceptibility genes in nuclear families with multiple affected siblings in Finland by Qiao, Qing, Osterholm, Anne-May, He, Bing, Pitkäniemi, Janne, Cordell, Heather J, Sarti, Cinzia, Kinnunen, Leena, Tuomilehto-Wolf, Eva, Tryggvason, Karl, Tuomilehto, Jaakko

“…A genome-wide search for genes that predispose to type 1 diabetes using linkage analysis was performed using 900 microsatellite markers in 70 nuclear families…”
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The Finland–United States Investigation of Non–Insulin-Dependent Diabetes Mellitus Genetics (FUSION) Study. I. An Autosomal Genome Scan for Genes That Predispose to Type 2 Diabetes by Ghosh, Soumitra, Watanabe, Richard M., Valle, Timo T., Hauser, Elizabeth R., Magnuson, Victoria L., Langefeld, Carl D., Ally, Delphine S., Mohlke, Karen L., Silander, Kaisa, Kohtamäki, Kimmo, Chines, Peter, Balow, James, Birznieks, Gunther, Chang, Jennie, Eldridge, William, Erdos, Michael R., Karanjawala, Zarir E., Knapp, Julie I., Kudelko, Kristina, Martin, Colin, Morales-Mena, Anabelle, Musick, Anjene, Musick, Tiffany, Pfahl, Carrie, Porter, Rachel, Rayman, Joseph B., Rha, David, Segal, Leonid, Shapiro, Shane, Sharaf, Ravi, Shurtleff, Ben, So, Alistair, Tannenbaum, Joyce, Te, Catherine, Tovar, Jason, Unni, Arun, Welch, Christian, Whiten, Ray, Witt, Alyson, Blaschak-Harvan, Jillian, Douglas, Julie A., Duren, William L., Epstein, Michael P., Fingerlin, Tasha E., Kaleta, Hong Shi, Lange, Ethan M., Li, Chun, McEachin, Richard C., Stringham, Heather M., Trager, Edward, White, Peggy P., Eriksson, Johan, Toivanen, Liisa, Vidgren, Gabriele, Nylund, Stella J., Tuomilehto-Wolf, Eva, Ross, Edna H., Demirchyan, Elza, Hagopian, William A., Buchanan, Thomas A., Tuomilehto, Jaakko, Bergman, Richard N., Collins, Francis S., Boehnke, Michael

“…We performed a genome scan at an average resolution of 8 cM in 719 Finnish sib pairs with type 2 diabetes. Our strongest results are for chromosome 20, where…”
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Investigation of KIR Gene Frequencies in Type 1 Diabetes Mellitus by Middleton, Derek, Halfpenny, Iris, Meenagh, Ashley, Williams, Fionnula, Sivula, Jyrki, Tuomilehto-Wolf, Eva

“…The frequency of killer immunoglobulinlike receptors (KIR) genes was examined in type 1 diabetes mellitus patients and controls from Finland. The KIR gene 2DS5…”
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The genetically isolated populations of Finland and Sardinia may not be a panacea for linkage disequilibrium mapping of common disease genes by Todd, John A, Eaves, Iain A, Merriman, Tony R, Barber, Rachael A, Nutland, Sarah, Tuomilehto-Wolf, Eva, Tuomilehto, Jaakko, Cucca, Francesco

“…The choice of which population to study in the mapping of common disease genes may be critical. Isolated founder populations, such as that found in Finland,…”
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Type 2 Diabetes: Evidence for Linkage on Chromosome 20 in 716 Finnish Affected Sib Pairs by Ghosh, Soumitra, Watanabe, Richard M., Hauser, Elizabeth R., Valle, Timo, Magnuson, Victoria L., Erdos, Michael R., Langefeld, Carl D., Balow, James, Ally, Delphine S., Kohtamaki, Kimmo, Chines, Peter, Birznieks, Gunther, Kaleta, Hong-Shi, Musick, Anjene, Te, Catherine, Tannenbaum, Joyce, Eldridge, William, Shapiro, Shane, Martin, Colin, Witt, Alyson, So, Alistair, Chang, Jennie, Shurtleff, Ben, Porter, Rachel, Kudelko, Kristina, Unni, Arun, Segal, Leonid, Sharaf, Ravi, Blaschak-Harvan, Jillian, Eriksson, Johan, Tenkula, Tuula, Vidgren, Gabriele, Ehnholm, Christian, Tuomilehto-Wolf, Eva, Hagopian, William, Buchanan, Thomas A., Tuomilehto, Jaakko, Bergman, Richard N., Collins, Francis S., Boehnke, Michael

“…We are conducting a genome scan at an average resolution of 10 centimorgans (cM) for type 2 diabetes susceptibility genes in 716 affected sib pairs from 477…”
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Association of SLC11A1 (NRAMP1) with persistent oligoarticular and polyarticular rheumatoid factor–negative juvenile idiopathic arthritis in Finnish patients: Haplotype analysis in Finnish families by Runstadler, Jonathan A., Säilä, Hanna, Savolainen, Anneli, Leirisalo‐Repo, Marjatta, Aho, Kimmo, Tuomilehto‐Wolf, Eva, Tuomilehto, Jaakko, Seldin, Michael F.

“…Objective The SLC11A1 (formerly called NRAMP1) gene is important in natural resistance to a variety of intracellular infections mediated by macrophages and has…”
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Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes by Smyth, Deborah J, Howson, Joanna M M, Lowe, Christopher E, Walker, Neil M, Lam, Alex C, Nutland, Sarah, Hutchings, Jayne, Tuomilehto-Wolf, Eva, Tuomilehto, Jaakko, Guja, Cristian, Ionescu-Tîrgoviste, Constantin, Undlien, Dag E, Rønningen, Kjersti S, Savage, David, Dunger, David B, Twells, Rebecca C J, McArdle, Wendy L, Strachan, David P, Todd, John A

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The Finland–United States Investigation of Non–Insulin-Dependent Diabetes Mellitus Genetics (FUSION) Study. II. An Autosomal Genome Scan for Diabetes-Related Quantitative-Trait Loci by Watanabe, Richard M., Ghosh, Soumitra, Langefeld, Carl D., Valle, Timo T., Hauser, Elizabeth R., Magnuson, Victoria L., Mohlke, Karen L., Silander, Kaisa, Ally, Delphine S., Chines, Peter, Blaschak-Harvan, Jillian, Douglas, Julie A., Duren, William L., Epstein, Michael P., Fingerlin, Tasha E., Kaleta, Hong Shi, Lange, Ethan M., Li, Chun, McEachin, Richard C., Stringham, Heather M., Trager, Edward, White, Peggy P., Balow, James, Birznieks, Gunther, Chang, Jennie, Eldridge, William, Erdos, Michael R., Karanjawala, Zarir E., Knapp, Julie I., Kudelko, Kristina, Martin, Colin, Morales-Mena, Anabelle, Musick, Anjene, Musick, Tiffany, Pfahl, Carrie, Porter, Rachel, Rayman, Joseph B., Rha, David, Segal, Leonid, Shapiro, Shane, Sharaf, Ravi, Shurtleff, Ben, So, Alistair, Tannenbaum, Joyce, Te, Catherine, Tovar, Jason, Unni, Arun, Welch, Christian, Whiten, Ray, Witt, Alyson, Kohtamäki, Kimmo, Ehnholm, Christian, Eriksson, Johan, Toivanen, Liisa, Vidgren, Gabriele, Nylund, Stella J., Tuomilehto-Wolf, Eva, Ross, Edna H., Demirchyan, Elza, Hagopian, William A., Buchanan, Thomas A., Tuomilehto, Jaakko, Bergman, Richard N., Collins, Francis S., Boehnke, Michael

“…Type 2 diabetes mellitus is a complex disorder encompassing multiple metabolic defects. We report results from an autosomal genome scan for type 2…”
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Parameters for reliable results in genetic association studies in common disease by Todd, John A, Dahlman, Ingrid, Eaves, Iain A, Kosoy, Roman, Morrison, V. Anne, Heward, Joanne, Gough, Stephen C.L, Allahabadia, Amit, Franklyn, Jayne A, Tuomilehto, Jaakko, Tuomilehto-Wolf, Eva, Cucca, Francesco, Guja, Cristian, Ionescu-Tirgoviste, Constantin, Stevens, Helen, Carr, Philippa, Nutland, Sarah, McKinney, Patricia, Shield, Julian P, Wang, William, Cordell, Heather J, Walker, Neil, Concannon, Patrick

“…It is increasingly apparent that the identification of true genetic associations in common multifactorial disease will require studies comprising thousands…”
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