Cavernosal tissue nitrite, nitrate, malondialdehyde and glutathione levels in diabetic and non-diabetic erectile dysfunction

Summary The aim of this study is to investigate the role of nitric oxide (NO) stabile end products, membrane lipid peroxidation and antioxidant defensive mechanism in diabetic erectile dysfunction (ED) and compare these parameters with non‐diabetic ED groups. We examined the penile cavernosal tissue...

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Bibliographic Details
Published in:	International journal of andrology Vol. 26; no. 4; pp. 250 - 254
Main Authors:	Tuncayengin, Alper, Biri, Hasan, Onaran, Metin, Şen, İlker, Tuncayengin, Özlem, Polat, Fevzi, Erbaş, Deniz, Bozkirli, İbrahim
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Science Ltd 01-08-2003 Blackwell
Subjects:	Adult Aged Biological and medical sciences Diabetes Complications diabetes mellitus erectile dysfunction Erectile Dysfunction - etiology Erectile Dysfunction - metabolism Fundamental and applied biological sciences. Psychology glutathione Glutathione - metabolism Humans Male malondialdehyde Malondialdehyde - metabolism Middle Aged Nitrates - metabolism nitric oxide Nitrites - metabolism Nitrogen Compounds - metabolism Penis - metabolism nitric oxide diabetes mellitus malondialdehyde glutathione erectile dysfunction
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Summary:	Summary The aim of this study is to investigate the role of nitric oxide (NO) stabile end products, membrane lipid peroxidation and antioxidant defensive mechanism in diabetic erectile dysfunction (ED) and compare these parameters with non‐diabetic ED groups. We examined the penile cavernosal tissues, obtained from 22 patients who had undergone surgery of penile prostheses implantation, for the nitrite, nitrate, malondialdehyde (MDA) and glutathione (GSH) levels. Eight patients were suffering from diabetic erectile dysfunction (ED) and 14 patients had non‐diabetic ED. Nitrite and nitrate levels were lower; MDA and GSH levels were higher in the diabetic group. There were statistically significant differences between diabetic and non‐diabetic groups amongst the nitrite (p < 0.001), nitrate (p < 0.01), MDA (p < 0.001) and GSH (p < 0.01) levels. Our data provide evidence that NO deficiency, possibly due to the membrane lipid peroxidation and defective antioxidant defensive mechanism, may contribute to the development of diabetic ED and thus is involved in the pathogenesis of ED in diabetic patients.
Bibliography:	ArticleID:IJAN427 istex:5E0A422F7924A6CE6911FAB047DF96AB59A4F293 ark:/67375/WNG-DJ78ZJRC-M ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0105-6263 1365-2605
DOI:	10.1046/j.1365-2605.2003.00427.x