Levels of oxidative stress parameters and the protective effects of melatonin in psychosis model rat testis

Aim： To evaluate the effects of melatonin on antioxidant enzyme levels and histopathologic changes in dizocilpine （MK-801）-induced psychosis model rat testis. Methods： A total of 24 adult male Wistar-Albino rats were divided into three groups with 8 in each. Group I was used as control. Rats in Grou...

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Published in:	Asian journal of andrology Vol. 10; no. 2; pp. 259 - 265
Main Authors:	Parlaktas, Bekir S., Ozyurt, Birsen, Ozyurt, Huseyin, Tunc, Ayten T., Akbas, Ali
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-03-2008 Medknow Publications & Media Pvt. Ltd
Subjects:	Animals antioxidant enzymes Antioxidants - pharmacology Disease Models, Animal dizocilpine Dizocilpine Maleate - adverse effects Dizocilpine Maleate - pharmacology Male Malondialdehyde melatonin Melatonin - pharmacology Mental Disorders - chemically induced Nitric Oxide oxidative stress Oxidative Stress - drug effects Protein Carbonylation Psychosis Psychotropic Drugs - adverse effects Psychotropic Drugs - pharmacology Rats Rats, Wistar testis Testis - drug effects Testis - enzymology Testis - pathology 抗氧化酶氧化性精神状况退黑激素
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Summary:	Aim： To evaluate the effects of melatonin on antioxidant enzyme levels and histopathologic changes in dizocilpine （MK-801）-induced psychosis model rat testis. Methods： A total of 24 adult male Wistar-Albino rats were divided into three groups with 8 in each. Group I was used as control. Rats in Group II were injected with MK-801 （0.5 mg/kg body weight i.p. for 5 days）. In addition to MK-801, melatonin （50 mg/kg body weight i.p. once a day for 5 days） was injected into the rats in Group Ⅲ. The testes were harvested bilaterally for biochemical and histopathological examinations. Antioxidant enzyme activities, malondialdehyde, protein carbonyl and nitric oxide （NO） levels in testicular tissues were analyzed using spectrophotometric analysis methods. Histopathological examinations of the testes were also performed. Results： MK-801 induced testicular damage, which resulted in significant oxidative stress （OS） by increasing the levels of antioxidant enzymes. The malondialdehyde, protein carbonyl and NO levels were increased in testicular tissues of rats. Treatment with melatonin led to significant decrease in oxidative injury. Administration of melatonin also reduced the detrimental histopathologic effects caused by MK-801. Conclusion： The results of the present study showed that MK-801 cause OS in testicular tissues of rats and treatment with melatonin can reduce the harmful effects＇of MK-801. （Asian JAndro12008 Mar; 10： 259-265）
Bibliography:	R69 31-1795/R testis; dizocilpine; psychosis; oxidative stress; melatonin; antioxidant enzymes testis antioxidant enzymes dizocilpine melatonin psychosis oxidative stress ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1008-682X 1745-7262
DOI:	10.1111/j.1745-7262.2008.00338.x