Search Results - "Tumiatti, Vincenzo"

Multi-target-Directed Ligands To Combat Neurodegenerative Diseases by Cavalli, Andrea, Bolognesi, Maria Laura, Minarini, Anna, Rosini, Michela, Tumiatti, Vincenzo, Recanatini, Maurizio, Melchiorre, Carlo

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Multifunctional tacrine derivatives in Alzheimer's disease by Minarini, Anna, Milelli, Andrea, Simoni, Elena, Rosini, Michela, Bolognesi, Maria Laura, Marchetti, Chiara, Tumiatti, Vincenzo

“…Tacrine (1) was the first acetylcholinesterase inhibitor (AChEI) introduced in therapy for the treatment of Alzheimer's disease (AD), but similarly to the most…”
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Design of Experiments and Optimization of Monacolin K Green Extraction from Red Yeast Rice by Ultra-High-Performance Liquid Chromatography by Davani, Lara, Terenzi, Cristina, De Simone, Angela, Tumiatti, Vincenzo, Andrisano, Vincenza, Montanari, Serena

“…Monacolin K (MK), in red yeast rice (RYR) in the forms of lactone (LMK) and hydroxy acid (AMK), is known for its anti-hypercholesterolemic activity. Under the…”
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Tumor vascular targeted liposomal-bortezomib minimizes side effects and increases therapeutic activity in human neuroblastoma by Zuccari, Guendalina, Milelli, Andrea, Pastorino, Fabio, Loi, Monica, Petretto, Andrea, Parise, Amelia, Marchetti, Chiara, Minarini, Anna, Cilli, Michele, Emionite, Laura, Di Paolo, Daniela, Brignole, Chiara, Piaggio, Francesca, Perri, Patrizia, Tumiatti, Vincenzo, Pistoia, Vito, Pagnan, Gabriella, Ponzoni, Mirco

“…Neuroblastoma is a childhood cancer with poor long-term prognosis in advanced stages. A major aim in neuroblastoma therapy is to develop targeted drug delivery…”
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Polyamines in Drug Discovery: From the Universal Template Approach to the Multitarget-Directed Ligand Design Strategy by Melchiorre, Carlo, Bolognesi, Maria Laura, Minarini, Anna, Rosini, Michela, Tumiatti, Vincenzo

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Phenolic and Antioxidant Characterization of Fruit By-Products for Their Nutraceuticals and Dietary Supplements Valorization under a Circular Bio-Economy Approach by Terenzi, Cristina, Bermudez, Gabriela, Medri, Francesca, Davani, Lara, Tumiatti, Vincenzo, Andrisano, Vincenza, Montanari, Serena, De Simone, Angela

“…Agri-food by-products, obtained as waste from the food industry, negatively impact the global economy and the environment. In order to valorize waste materials…”
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Macrocyclic naphthalene diimides as G-quadruplex binders by Marchetti, Chiara, Minarini, Anna, Tumiatti, Vincenzo, Moraca, Federica, Parrotta, Lucia, Alcaro, Stefano, Rigo, Riccardo, Sissi, Claudia, Gunaratnam, Mekala, Ohnmacht, Stephan A., Neidle, Stephen, Milelli, Andrea

“…[Display omitted] The synthesis, biological and molecular modeling evaluation of a series of macrocyclic naphthalene diimides is reported. The present…”
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Novel Class of Quinone-Bearing Polyamines as Multi-Target-Directed Ligands To Combat Alzheimer's Disease by Bolognesi, Maria Laura, Banzi, Rita, Bartolini, Manuela, Cavalli, Andrea, Tarozzi, Andrea, Andrisano, Vincenza, Minarini, Anna, Rosini, Michela, Tumiatti, Vincenzo, Bergamini, Christian, Fato, Romana, Lenaz, Giorgio, Hrelia, Patrizia, Cattaneo, Antonino, Recanatini, Maurizio, Melchiorre, Carlo

“…One of the characteristics of Alzheimer's disease (AD) that hinders the discovery of effective disease-modifying therapies is the multifactorial nature of its…”
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Multitarget-directed ligands: innovative chemical probes and therapeutic tools against Alzheimer's disease by Bolognesi, Maria Laura, Simoni, Elena, Rosini, Michela, Minarini, Anna, Tumiatti, Vincenzo, Melchiorre, Carlo

“…Multitarget agents directed at selected molecular targets involved in the pathogenic cascade of Alzheimer's disease (AD) have been increasingly sought after in…”
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Isothiocyanate synthetic analogs: biological activities, structure-activity relationships and synthetic strategies by Milelli, Andrea, Fimognari, Carmela, Ticchi, Nicole, Neviani, Paolo, Minarini, Anna, Tumiatti, Vincenzo

“…Sulforaphane is a natural product that is constantly under biological investigation for its unique biological properties. This naturally occurring…”
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Design, Synthesis, and Biological Evaluation of Substituted Naphthalene Imides and Diimides as Anticancer Agent by Tumiatti, Vincenzo, Milelli, Andrea, Minarini, Anna, Micco, Marialuisa, Gasperi Campani, Anna, Roncuzzi, Laura, Baiocchi, Daniela, Marinello, Jessica, Capranico, Giovanni, Zini, Maddalena, Stefanelli, Claudio, Melchiorre, Carlo

“…Naphthalimmide (NI) and 1,4,5,8-naphthalentetracarboxylic diimide (NDI) derivatives were synthesized and evaluated for their antiproliferative activity. NDI…”
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Structure–activity relationships of novel substituted naphthalene diimides as anticancer agents by Milelli, Andrea, Tumiatti, Vincenzo, Micco, Marialuisa, Rosini, Michela, Zuccari, Guendalina, Raffaghello, Lizzia, Bianchi, Giovanna, Pistoia, Vito, Fernando Díaz, J., Pera, Benet, Trigili, Chiara, Barasoain, Isabel, Musetti, Caterina, Toniolo, Marianna, Sissi, Claudia, Alcaro, Stefano, Moraca, Federica, Zini, Maddalena, Stefanelli, Claudio, Minarini, Anna

“…Novel 1,4,5,8-naphthalenetetracarboxylic diimide (NDI) derivatives were synthesized and evaluated for their antiproliferative activity on a wide number of…”
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From dual binding site acetylcholinesterase inhibitors to multi-target-directed ligands (MTDLs): a step forward in the treatment of Alzheimer's disease by Bolognesi, Maria Laura, Minarini, Anna, Rosini, Michela, Tumiatti, Vincenzo, Melchiorre, Carlo

“…Alzheimer's disease is a complex neurodegenerative disorder with a multifaceted pathogenesis. This fact has long halted the development of effective…”
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Synthetic polyamines activating autophagy: Effects on cancer cell death by Minarini, Anna, Zini, Maddalena, Milelli, Andrea, Tumiatti, Vincenzo, Marchetti, Chiara, Nicolini, Benedetta, Falconi, Mirella, Farruggia, Giovanna, Cappadone, Concettina, Stefanelli, Claudio

“…The ability of symmetrically substituted long chain polymethylene tetramines, methoctramine (1) and its analogs 2–4 to kill cancer cells was studied. We found…”
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In vitro and in vivo evaluation of polymethylene tetraamine derivatives as NMDA receptor channel blockers by Saiki, Ryotaro, Yoshizawa, Yuki, Minarini, Anna, Milelli, Andrea, Marchetti, Chiara, Tumiatti, Vincenzo, Toida, Toshihiko, Kashiwagi, Keiko, Igarashi, Kazuei

“…The biological activities of six symmetrically substituted 2-methoxy-benzyl polymethylene tetraamines (1–4) and diphenylethyl polymethylene tetraamines (5 and…”
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Synthetic polyamines as potential amine oxidase inhibitors: a preliminary study by Emanuela, Bonaiuto, Minarini, Anna, Tumiatti, Vincenzo, Milelli, Andrea, Lunelli, Michele, Pegoraro, Maurizio, Rizzoli, Valeria, Di Paolo, Maria Luisa

“…In the last few decades, medicinal chemists have carried out extensive research on synthetic polyamines for use as anticancer drugs and multitarget-directed…”
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Lipoic acid, a lead structure for multi-target-directed drugs for neurodegeneration by Bolognesi, Maria L, Minarini, Anna, Tumiatti, Vincenzo, Melchiorre, Carlo

“…Nowadays, drug discovery based on a single-target-directed strategy seems inappropriate for the treatment of complex diseases that have multiple pathogenic…”
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Study of the cytotoxic effects of the new synthetic Isothiocyanate CM9 and its fullerene derivative on human T-leukemia cells by De Gianni, Elena, Turrini, Eleonora, Milelli, Andrea, Maffei, Francesca, Carini, Marco, Minarini, Anna, Tumiatti, Vincenzo, Ros, Tatiana Da, Prato, Maurizio, Fimognari, Carmela

“…One important strategy to develop effective anticancer agents is based on natural products. Many active phytochemicals are in human clinical trials and have…”
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Cytotoxicity of methoctramine and methoctramine-related polyamines by Zini, Maddalena, Passariello, Catherine L., Gottardi, Davide, Cetrullo, Silvia, Flamigni, Flavio, Pignatti, Carla, Minarini, Anna, Tumiatti, Vincenzo, Milelli, Andrea, Melchiorre, Carlo, Stefanelli, Claudio

“…Methoctramine and its analogues are polymethylene tetramines that selectively bind to a variety of receptor sites. Although these compounds are widely used as…”
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Glycogen Synthase Kinase 3β: A New Gold Rush in Anti-Alzheimer's Disease Multitarget Drug Discovery? by De Simone, Angela, Tumiatti, Vincenzo, Andrisano, Vincenza, Milelli, Andrea

“…Alzheimer's disease (AD), like other multifactorial diseases, is the result of a systemic breakdown of different physiological networks. As result, several…”
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