Search Results - "Tumer, Nihal"

Protective effects of resveratrol on aging-induced cognitive impairment in rats by Gocmez, Semil Selcen, Gacar, Nejat, Utkan, Tijen, Gacar, Gulcin, Scarpace, Philip J., Tumer, Nihal

“…•Aging impaired emotional and spatial learning and memory in rats.•Inflammatory cytokines were increased by aging.•Resveratrol reversed the aging impaired…”
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Regulation of adiponectin and leptin gene expression in white and brown adipose tissues: influence of β3-adrenergic agonists, retinoic acid, leptin and fasting by Zhang, Yi, Matheny, Michael, Zolotukhin, Sergei, Tumer, Nihal, Scarpace, Philip J

“…Circulating adiponectin levels fall whereas leptin levels rise with obesity, suggesting that regulation of these two adipocyte-derived hormones may be…”
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The act of voluntary wheel running reverses dietary hyperphagia and increases leptin signaling in ventral tegmental area of aged obese rats by Shapiro, Alexandra, Cheng, Kit-Yan, Gao, Yongxin, Seo, Dong-Oh, Anton, Steve, Carter, Christy S, Zhang, Yi, Tumer, Nihal, Scarpace, Philip J

“…To test the hypothesis that exercise increases central leptin signaling, and thus reduces dietary weight gain in an aged obese model, we assessed the effects…”
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Short-term exercise training can improve myocardial tolerance to I/R without elevation in heat shock proteins by Hamilton, K L, Powers, S K, Sugiura, T, Kim, S, Lennon, S, Tumer, N, Mehta, J L

“…We examined the effects of 3 days of exercise in a cold environment on the expression of left ventricular (LV) heat shock proteins (HSPs) and contractile…”
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Simultaneous POMC gene transfer to hypothalamus and brainstem increases physical activity, lipolysis and reduces adult-onset obesity by Zhang, Yi, Rodrigues, Enda, Li, Gang, Gao, Yongxin, King, Michael, Carter, Christy S., Tumer, Nihal, Cheng, Kit-Yan, Scarpace, Philip J.

“…Pro‐opiomelanocortin (POMC) neurons are identified in two brain sites, the arcuate nucleus of the hypothalamus and nucleus of the solitary tract (NTS) in…”
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Effect of high-fat diet feeding on hypothalamic redox signaling and central blood pressure regulation by Erdos, Benedek, Broxson, Christopher S, Cudykier, Idan, Basgut, Bilgen, Whidden, Melissa, Landa, Tessa, Scarpace, Philip J, Tümer, Nihal

“…We examined the effect of high-fat (HF) feeding on blood pressure (BP) regulation, including hypothalamic redox signaling, as well as the changes in diurnal…”
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A Proteomic Evaluation of Sympathetic Activity Biomarkers of the Hypothalamus-Pituitary-Adrenal Axis by Western Blotting Technique Following Experimental Traumatic Brain Injury by Toklu, Hale Zerrin, Sakarya, Yasemin, Tümer, Nihal

“…Endocrine disorders and autonomic dysfunction are common paradigms following traumatic brain injury (TBI). Alterations in the hypothalamus-pituitary-adrenal…”
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Rapamycin Normalizes Serum Leptin by Alleviating Obesity and Reducing Leptin Synthesis in Aged Rats by Scarpace, Philip J, Matheny, Michael, Strehler, Kevin Y E, Toklu, Hale Zerrin, Kirichenko, Nataliya, Carter, Christy S, Morgan, Drake, Tümer, Nihal

“…This investigation examines whether a low intermittent dose of rapamycin will avoid the hyperlipidemia and diabetes-like syndrome associated with rapamycin…”
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Overpressure blast injury-induced oxidative stress and neuroinflammation response in rat frontal cortex and cerebellum by Toklu, Hale Z., Yang, Zhihui, Oktay, Sehkar, Sakarya, Yasemin, Kirichenko, Nataliya, Matheny, Michael K., Muller-Delp, Judy, Strang, Kevin, Scarpace, Philip J., Wang, Kevin K.W., Tümer, Nihal

“…[Display omitted] •Overpressure blast injury (OBI) induces oxidative stress and inflammation in lung and brain.•Repeated OBI causes edema and disrupts blood…”
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Prevention and reversal of diet-induced leptin resistance with a sugar-free diet despite high fat content by Shapiro, Alexandra, Tümer, Nihal, Gao, Yongxin, Cheng, Kit-Yan, Scarpace, Philip J.

“…Chronic consumption of a Western-type diet, containing both elevated sugar and fat, results in leptin resistance. We hypothesised that fructose, as part of the…”
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ACE2 activator diminazene aceturate reduces adiposity but preserves lean mass in young and old rats by Bruce, Erin B., Sakarya, Yasemin, Kirichenko, Nataliya, Toklu, Hale Z., Sumners, Colin, Morgan, Drake, Tümer, Nihal, Scarpace, Philip J., Carter, Christy S.

“…The obesity epidemic is multi-generational and is particularly debilitating in the aging population, necessitating the use of pharmaceutical interventions…”
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Rapamycin Versus Intermittent Feeding: Dissociable Effects on Physiological and Behavioral Outcomes When Initiated Early and Late in Life by Carter, Christy S, Khamiss, Dallas, Matheny, Michael, Toklu, Hale Z, Kirichenko, Nataliya, Strehler, Kevin Y E, Tümer, Nihal, Scarpace, Philip J, Morgan, Drake

“…Rapamycin, an inhibitor of the mammalian target of rapamycin pathway, has been shown to increase mammalian life span; less is known concerning its effect on…”
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Short-term exercise training protects against doxorubicin-induced cardiac mitochondrial damage independent of HSP72 by Kavazis, Andreas N, Smuder, Ashley J, Min, Kisuk, Tümer, Nihal, Powers, Scott K

“…Doxorubicin (Dox) is an antitumor agent used in cancer treatment, but its clinical use is limited due to cardiotoxicity. Although exercise training can defend…”
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Synergy Between Leptin Therapy and a Seemingly Negligible Amount of Voluntary Wheel Running Prevents Progression of Dietary Obesity in Leptin-Resistant Rats by Shapiro, Alexandra, Matheny, Michael, Zhang, Yi, Tümer, Nihal, Cheng, Kit-Yan, Rogrigues, Enda, Zolotukhin, Sergei, Scarpace, Philip J.

“…Synergy Between Leptin Therapy and a Seemingly Negligible Amount of Voluntary Wheel Running Prevents Progression of Dietary Obesity in Leptin-Resistant Rats…”
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Effect of High-Salt Diet on Age-Related High Blood Pressure and Hypothalamic Redox Signaling by Basgut, Bilgen, Whidden, Melissa A, Kirichenko, Nataliya, Woods, Mary, Erdos, Benedek, Scarpace, Philip J, Tümer, Nihal

“…The aim of this study was to investigate the effect of a high salt (HS) diet on age-related changes in blood pressure (BP) and the possible role played by…”
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Oestradiol and leptin have separate but additive anorexigenic effects and differentially target fat mass in rats by Côté, Isabelle, Green, Sara M., Yarrow, Joshua F., Conover, Christine F., Toklu, Hale Z., Morgan, Drake, Carter, Christy S., Tümer, Nihal, Scarpace, Philip J.

“…We recently showed that male rats exhibit lower hypophagia and body weight loss compared to female rats following central leptin delivery, suggesting a role…”
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Intracerebroventricular tempol administration in older rats reduces oxidative stress in the hypothalamus but does not change STAT3 signalling or SIRT1/AMPK pathway by Toklu, Hale Z, Scarpace, Philip J, Sakarya, Yasemin, Kirichenko, Nataliya, Matheny, Michael, Bruce, Erin B, Carter, Christy S, Morgan, Drake, Tümer, Nihal

“…Hypothalamic inflammation and increased oxidative stress are believed to be mechanisms that contribute to obesity…”
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Anorexic response to rapamycin does not appear to involve a central mechanism by Toklu, Hale Z., Bruce, Erin B., Sakarya, Yasemin, Carter, Christy S., Morgan, Drake, Matheny, Michael K., Kirichenko, Nataliya, Scarpace, Philip J., Tümer, Nihal

“…Summary The authors have previously demonstrated that a low and intermittent peripheral dose of rapamycin (1 mg/kg three times/week) to rats inhibited mTORC1…”
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Onset of leptin resistance shows temporal differences related to dose or pulsed treatment by Strehler, Kevin Y.E., Matheny, Michael, Kirichenko, Nataliya, Sakarya, Yasemin, Bruce, Erin, Toklu, Hale Zerrin, Carter, Christy S., Morgan, Drake, Tümer, Nihal, Scarpace, Philip J.

“…Leptin administration results in leptin resistance presenting a significant barrier to therapeutic use of leptin. Consequently, we examined two hypotheses. The…”
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Lifelong caloric restriction prevents age-induced oxidative stress in the sympathoadrenal system of Fischer 344 x Brown Norway rats by Whidden, Melissa A., Kirichenko, Nataliya, Halici, Zekai, Erdos, Benedek, Foster, Thomas C., Tümer, Nihal

“…► Lipid peroxidation and tyrosine nitration are elevated in the adrenal medulla of aged rats. ► Endogenous antioxidant enzymes are depleted in the hypothalamus…”
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