Search Results - "Tumba, Nancy"

The Neutralization Breadth of HIV-1 Develops Incrementally over Four Years and Is Associated with CD4+ T Cell Decline and High Viral Load during Acute Infection by GRAY, Elin S, MADIGA, Maphuti C, ABDOOL KARIM, Salim S, MORRIS, Lynn, HERMANUS, Tandile, MOORE, Penny L, WIBMER, Constantinos Kurt, TUMBA, Nancy L, WERNER, Lise, MLISANA, Koleka, SIBEKO, Sengeziwe, WILLIAMSON, Carolyn

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Evolution of an HIV glycan–dependent broadly neutralizing antibody epitope through immune escape by Moore, Penny L, Gray, Elin S, Wibmer, C Kurt, Bhiman, Jinal N, Nonyane, Molati, Sheward, Daniel J, Hermanus, Tandile, Bajimaya, Shringkhala, Tumba, Nancy L, Abrahams, Melissa-Rose, Lambson, Bronwen E, Ranchobe, Nthabeleng, Ping, Lihua, Ngandu, Nobubelo, Karim, Quarraisha Abdool, Karim, Salim S Abdool, Swanstrom, Ronald I, Seaman, Michael S, Williamson, Carolyn, Morris, Lynn

“…A minority of HIV-1–infected individuals develop broadly neutralizing antibodies, which are considered an important goal of many HIV vaccine strategies. Moore…”
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Covalent binding of human two-domain CD4 to an HIV-1 subtype C SOSIP.664 trimer modulates its structural dynamics by Tumba, Nancy L., Naicker, Previn, Stoychev, Stoyan, Killick, Mark A., Owen, Gavin R., Papathanasopoulos, Maria A.

“…The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) mediates host cell infection by binding to the cellular receptor CD4. Recombinant…”
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Ibogaine administration following repeated morphine administration upregulates myelination markers 2', 3'-cyclic nucleotide 3'-phosphodiesterase (CNP) and myelin basic protein (MBP) mRNA and protein expression in the internal capsule of Sprague Dawley rats by Govender, Demi, Moloko, Leila, Papathanasopoulos, Maria, Tumba, Nancy, Owen, Gavin, Calvey, Tanya

“…Ibogaine is a psychedelic alkaloid being investigated as a possible treatment for opioid use disorder. Ibogaine has a multi-receptor profile with affinities…”
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Viral escape from HIV-1 neutralizing antibodies drives increased plasma neutralization breadth through sequential recognition of multiple epitopes and immunotypes by Wibmer, Constantinos Kurt, Bhiman, Jinal N, Gray, Elin S, Tumba, Nancy, Abdool Karim, Salim S, Williamson, Carolyn, Morris, Lynn, Moore, Penny L

“…Identifying the targets of broadly neutralizing antibodies to HIV-1 and understanding how these antibodies develop remain important goals in the quest to…”
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Strain-Specific V3 and CD4 Binding Site Autologous HIV-1 Neutralizing Antibodies Select Neutralization-Resistant Viruses by Moody, M. Anthony, Gao, Feng, Gurley, Thaddeus C., Amos, Joshua D., Kumar, Amit, Hora, Bhavna, Marshall, Dawn J., Whitesides, John F., Xia, Shi-Mao, Parks, Robert, Lloyd, Krissey E., Hwang, Kwan-Ki, Lu, Xiaozhi, Bonsignori, Mattia, Finzi, Andrés, Vandergrift, Nathan A., Alam, S. Munir, Ferrari, Guido, Shen, Xiaoying, Tomaras, Georgia D., Kamanga, Gift, Cohen, Myron S., Sam, Noel E., Kapiga, Saidi, Gray, Elin S., Tumba, Nancy L., Morris, Lynn, Zolla-Pazner, Susan, Gorny, Miroslaw K., Mascola, John R., Hahn, Beatrice H., Shaw, George M., Sodroski, Joseph G., Liao, Hua-Xin, Montefiori, David C., Hraber, Peter T., Korber, Bette T., Haynes, Barton F.

“…The third variable (V3) loop and the CD4 binding site (CD4bs) of the HIV-1 envelope are frequently targeted by neutralizing antibodies (nAbs) in infected…”
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Polyclonal B Cell Responses to Conserved Neutralization Epitopes in a Subset of HIV-1-Infected Individuals by TOMARAS, Georgia D, BINLEY, James M, DECKER, Julie, WIBMER, Constantinos Kurt, FENG GAO, ALAM, S. Munir, EASTERBROOK, Philippa, KARIM, Salim Abdool, KAMANGA, Gift, CRUMP, John A, COHEN, Myron, SHAW, George M, GRAY, Elin S, MASCOLA, John R, HAYNES, Barton F, MONTEFIORI, David C, MORRIS, Lynn, CROOKS, Emma T, OSAWA, Keiko, MOORE, Penny L, TUMBA, Nancy, TONG, Tommy, XIAOYING SHEN, YATES, Nicole L

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Potent and Broad Neutralization of HIV-1 Subtype C by Plasma Antibodies Targeting a Quaternary Epitope Including Residues in the V2 Loop by MOORE, Penny L, GRAY, Elin S, SIBEKO, Sengeziwe, MLISANA, Koleka, ABDOOL KARIM, Salim S, WILLIAMSON, Carolyn, PINTER, Abraham, MORRIS, Lynn, SHEWARD, Daniel, MADIGA, Maphuti, RANCHOBE, Nthabeleng, ZHONG LAI, HONNEN, William J, NONYANE, Molati, TUMBA, Nancy, HERMANUS, Tandile

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Immunization with HIV-1 trimeric SOSIP.664 BG505 or founder virus C (FVCEnv) covalently complexed to two-domain CD4S60C elicits cross-clade neutralizing antibodies in New Zealand white rabbits by Tumba, Nancy L., Owen, Gavin R., Killick, Mark A., Papathanasopoulos, Maria A.

“…Background: An ongoing challenge in HIV-1 vaccine research is finding a novel HIV-1 envelope glycoprotein (Env)-based immunogen that elicits broadly…”
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UCLA1, a Synthetic Derivative of a gp120 RNA Aptamer, Inhibits Entry of Human Immunodeficiency Virus Type 1 Subtype C by MUFHANDU, Hazel T, GRAY, Elin S, MADIGA, Maphuti C, TUMBA, Nancy, ALEXANDRE, Kabamba B, KHOZA, Thandeka, WIBMER, Constantinos Kurt, MOORE, Penny L, MORRIS, Lynn, KHATI, Makobetsa

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Correction: Features of Recently Transmitted HIV-1 Clade C Viruses that Impact Antibody Recognition: Implications for Active and Passive Immunization by Rademeyer, Cecilia, Korber, Bette, Seaman, Michael S, Giorgi, Elena E, Thebus, Ruwayhida, Robles, Alexander, Sheward, Daniel J, Wagh, Kshitij, Garrity, Jetta, Carey, Brittany R, Gao, Hongmei, Greene, Kelli M, Tang, Haili, Bandawe, Gama P, Marais, Jinny C, Diphoko, Thabo E, Hraber, Peter, Tumba, Nancy, Moore, Penny L, Gray, Glenda E, Kublin, James, McElrath, M Juliana, Vermeulen, Marion, Middelkoop, Keren, Bekker, Linda-Gail, Hoelscher, Michael, Maboko, Leonard, Makhema, Joseph, Robb, Merlin L, Karim, Salim Abdool, Karim, Quarraisha Abdool, Kim, Jerome H, Hahn, Beatrice H, Gao, Feng, Swanstrom, Ronald, Morris, Lynn, Montefiori, David C, Williamson, Carolyn

“…[This corrects the article DOI: 10.1371/journal.ppat.1005742.]…”
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Amino Acid Changes in the HIV-1 gp41 Membrane Proximal Region Control Virus Neutralization Sensitivity by Bradley, Todd, Trama, Ashley, Tumba, Nancy, Gray, Elin, Lu, Xiaozhi, Madani, Navid, Jahanbakhsh, Fatemeh, Eaton, Amanda, Xia, Shi-Mao, Parks, Robert, Lloyd, Krissey E., Sutherland, Laura L., Scearce, Richard M., Bowman, Cindy M., Barnett, Susan, Abdool-Karim, Salim S., Boyd, Scott D., Melillo, Bruno, Smith, Amos B., Sodroski, Joseph, Kepler, Thomas B., Alam, S.Munir, Gao, Feng, Bonsignori, Mattia, Liao, Hua-Xin, Moody, M. Anthony, Montefiori, David, Santra, Sampa, Morris, Lynn, Haynes, Barton F.

“…Most HIV-1 vaccines elicit neutralizing antibodies that are active against highly sensitive (tier-1) viruses or rare cases of vaccine-matched…”
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Structure and immune recognition of trimeric pre-fusion HIV-1 Env by Pancera, Marie, Zhou, Tongqing, Druz, Aliaksandr, Georgiev, Ivelin S., Soto, Cinque, Gorman, Jason, Huang, Jinghe, Acharya, Priyamvada, Chuang, Gwo-Yu, Ofek, Gilad, Stewart-Jones, Guillaume B. E., Stuckey, Jonathan, Bailer, Robert T., Joyce, M. Gordon, Louder, Mark K., Tumba, Nancy, Yang, Yongping, Zhang, Baoshan, Cohen, Myron S., Haynes, Barton F., Mascola, John R., Morris, Lynn, Munro, James B., Blanchard, Scott C., Mothes, Walther, Connors, Mark, Kwong, Peter D.

“…The human immunodeficiency virus type 1 (HIV-1) envelope (Env) spike, comprising three gp120 and three gp41 subunits, is a conformational machine that…”
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Features of Recently Transmitted HIV-1 Clade C Viruses that Impact Antibody Recognition: Implications for Active and Passive Immunization by Rademeyer, Cecilia, Korber, Bette, Seaman, Michael S, Giorgi, Elena E, Thebus, Ruwayhida, Robles, Alexander, Sheward, Daniel J, Wagh, Kshitij, Garrity, Jetta, Carey, Brittany R, Gao, Hongmei, Greene, Kelli M, Tang, Haili, Bandawe, Gama P, Marais, Jinny C, Diphoko, Thabo E, Hraber, Peter, Tumba, Nancy, Moore, Penny L, Gray, Glenda E, Kublin, James, McElrath, M Juliana, Vermeulen, Marion, Middelkoop, Keren, Bekker, Linda-Gail, Hoelscher, Michael, Maboko, Leonard, Makhema, Joseph, Robb, Merlin L, Abdool Karim, Salim, Abdool Karim, Quarraisha, Kim, Jerome H, Hahn, Beatrice H, Gao, Feng, Swanstrom, Ronald, Morris, Lynn, Montefiori, David C, Williamson, Carolyn

“…The development of biomedical interventions to reduce acquisition of HIV-1 infection remains a global priority, however their potential effectiveness is…”
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A Fusion Intermediate gp41 Immunogen Elicits Neutralizing Antibodies to HIV-1 by Lai, Rachel P.J., Hock, Miriam, Radzimanowski, Jens, Tonks, Paul, Hulsik, David Lutje, Effantin, Gregory, Seilly, David J., Dreja, Hanna, Kliche, Alexander, Wagner, Ralf, Barnett, Susan W., Tumba, Nancy, Morris, Lynn, LaBranche, Celia C., Montefiori, David C., Seaman, Michael S., Heeney, Jonathan L., Weissenhorn, Winfried

“…The membrane-proximal external region (MPER) of the human immunodeficiency virus, type 1 (HIV-1) envelope glycoprotein subunit gp41 is targeted by potent…”
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Viral Escape from HIV-1 Neutralizing Antibodies Drives Increased Plasma Neutralization Breadth through Sequential Recognition of Multiple Epitopes and Immunotypes: e1003738 by Wibmer, Constantinos Kurt, Bhiman, Jinal N, Gray, Elin S, Tumba, Nancy, Karim, Salim SAbdool, Williamson, Carolyn, Morris, Lynn, Moore, Penny L

“…Identifying the targets of broadly neutralizing antibodies to HIV-1 and understanding how these antibodies develop remain important goals in the quest to…”
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Structure and immune recognition of trimeric prefusion HIV-1 Env by Pancera, Marie, Zhou, Tongqing, Druz, Aliaksandr, Georgiev, Ivelin S., Soto, Cinque, Gorman, Jason, Huang, Jinghe, Acharya, Priyamvada, Chuang, Gwo-Yu, Ofek, Gilad, Stewart-Jones, Guillaume B. E., Stuckey, Jonathan, Bailer, Robert T., Joyce, M. Gordon, Louder, Mark K., Tumba, Nancy, Yang, Yongping, Zhang, Baoshan, Cohen, Myron S., Haynes, Barton F., Mascola, John R., Morris, Lynn, Munro, James B., Blanchard, Scott C., Mothes, Walther, Connors, Mark, Kwong, Peter D.

“…The HIV-1-envelope (Env) spike, comprising three gp120 and three gp41 subunits, is a conformational machine that facilitates HIV-1 entry by rearranging from a…”
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Comparative analysis of expression and secretion of placental leptin in mammals by Zhao, Jing, Kunz, Thomas H, Tumba, Nancy, Schulz, Laura Clamon, Li, Chris, Reeves, Monica, Widmaier, Eric P

“…Increased plasma level of leptin appears to be a ubiquitous feature of pregnant mammals. The mechanisms by which leptin levels are increased may be species…”
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