Search Results - "Tumang, Joseph R."

PD-L2 expression extends beyond dendritic cells/macrophages to B1 cells enriched for VH11/VH12 and phosphatidylcholine binding by Zhong, Xuemei, Tumang, Joseph R, Gao, Wenda, Bai, Chunyan, Rothstein, Thomas L

“…B1 B cells are the major source of natural antibody that is essential for innate immunity. The B1 repertoire is skewed toward production of phosphatidylcholine…”
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Immunoglobulin secretion by B1 cells: Differential intensity and IRF4‐dependence of spontaneous IgM secretion by peritoneal and splenic B1 cells by Holodick, Nichol E, Tumang, Joseph R, Rothstein, Thomas L

“…Peritoneal B1 cells are typified by spontaneous, constitutive secretion of IgM natural antibody, detected by ELISPOT assay, among other means. Recently, this…”
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Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1 by Rosenbauer, Frank, Tenen, Daniel G, Owens, Bronwyn M, Yu, Li, Tumang, Joseph R, Steidl, Ulrich, Kutok, Jeffery L, Clayton, Linda K, Wagner, Katharina, Scheller, Marina, Iwasaki, Hiromi, Liu, Chunhui, Hackanson, Björn, Akashi, Koichi, Leutz, Achim, Rothstein, Thomas L, Plass, Christoph

“…Tight regulation of transcription factors, such as PU.1, is crucial for generation of all hematopoietic lineages. We previously reported that mice with a…”
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CD25 + B-1a Cells Express Aicda by Kaku, Hiroaki, Holodick, Nichol E, Tumang, Joseph R, Rothstein, Thomas L

“…B-1a cells are innate-like B-lymphocytes producing natural antibodies. Activation-induced cytidine deaminase (AID), a product of the gene, plays a central role…”
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Peritoneal and splenic B‐1 cells are separable by phenotypic, functional, and transcriptomic characteristics by Tumang, Joseph R., Hastings, William D., Bai, Chunyan, Rothstein, Thomas L.

“…B‐1 cells constitute a distinct B cell population with unique phenotypic and functional characteristics. Although the origin of B‐1 cells remains…”
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Cutting Edge: Spontaneously Ig-Secreting B-1 Cells Violate the Accepted Paradigm for Expression of Differentiation-Associated Transcription Factors by Tumang, Joseph R, Frances, Ruben, Yeo, Seung Geun, Rothstein, Thomas L

“…B-1 cells spontaneously secrete natural Ig that acts as a primary line of defense against infection. A major shortfall in our understanding of this key process…”
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Peritoneal B‐2 cells comprise a distinct B‐2 cell population with B‐1b‐like characteristics by Hastings, William D., Tumang, Joseph R., Behrens, Timothy W., Rothstein, Thomas L.

“…B‐1 and B‐2 cells are lymphocyte populations that differ in development, surface marker expression, tissue localization, and function. Though mainly found in…”
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Extreme skewing of annexin II and S100A6 expression identified by proteomic analysis of peritoneal B-1 cells by Francés, Rubén, Tumang, Joseph R., Rothstein, Thomas L.

“…B-1 cells differ phenotypically, biochemically and functionally from conventional B-2 cells. The origin of these differences remains uncertain. We hypothesized…”
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A CD25⁻ positive population of activated B1 cells expresses LIFR and responds to LIF by Tumang, Joseph R, Holodick, Nichol E, Vizconde, Teresa C, Kaku, Hiroaki, Francés, Rubén, Rothstein, Thomas L

“…B1 B cells defend against infectious microorganisms by spontaneous secretion of broadly reactive "natural" immunoglobulin that appears in the absence of…”
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Continual signaling is responsible for constitutive ERK phosphorylation in B-1a cells by Holodick, Nichol E., Tumang, Joseph R., Rothstein, Thomas L.

“…B-1a cells constitutively express phosphorylated, activated ERK, but the origin of pERK in B-1 cells has not been determined. To address this issue, we…”
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Functional Outcome of B Cell Activation by Chromatin Immune Complex Engagement of the B Cell Receptor and TLR9 by Busconi, Liliana, Bauer, Jason W, Tumang, Joseph R, Laws, Amy, Perkins-Mesires, Kristin, Tabor, Abigail S, Lau, Christina, Corley, Ronald B, Rothstein, Thomas L, Lund, Frances E, Behrens, Timothy W, Marshak-Rothstein, Ann

“…We have previously shown that rheumatoid factors produced by Fas-deficient autoimmune-prone mice typically bind autologous IgG2a with remarkably low affinity…”
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B cell receptor crosstalk: B cells express osteopontin through the combined action of the alternate and classical BCR signaling pathways by Guo, Benchang, Tumang, Joseph R., Rothstein, Thomas L.

“…Classical BCR signaling requires a number of signalosome mediators that are bypassed when BCR signaling follows an alternate pathway produced by prior exposure…”
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Eμ-BRD2 transgenic mice develop B-cell lymphoma and leukemia by Greenwald, Rebecca J., Tumang, Joseph R., Sinha, Anupama, Currier, Nicolas, Cardiff, Robert D., Rothstein, Thomas L., Faller, Douglas V., Denis, Gerald V.

“…Transgenic mice with lymphoid-restricted overexpression of the double bromodomain protein bromodomain-containing 2 (Brd2) develop splenic B-cell lymphoma and,…”
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Cutting Edge: B-1 Cells Are Deficient in Lck: Defective B Cell Receptor Signal Transduction in B-1 Cells Occurs in the Absence of Elevated Lck Expression by Frances, Ruben, Tumang, Joseph R, Rothstein, Thomas L

“…B-1 cells constitute a unique B cell subset that is primarily responsible for producing nonimmune Ig. This natural Ig acts as a principal line of defense…”
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B-1 cells express transgelin 2: Unexpected lymphocyte expression of a smooth muscle protein identified by proteomic analysis of peritoneal B-1 cells by Francés, Rubén, Tumang, Joseph R., Kaku, Hiroaki, Gurdak, Sean M., Rothstein, Thomas L.

“…B-1 cells constitute a unique B cell subset that differs phenotypically, biochemically, and functionally from the predominant population of conventional B-2…”
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CD5 +/Mac-1 − peritoneal B cells: A novel B cell subset that exhibits characteristics of B-1 cells by Hastings, William D., Gurdak, Sean M., Tumang, Joseph R., Rothstein, Thomas L.

“…The peritoneal cavity of mice is enriched for B-1 B cells, a lymphocyte subset that differs from conventional B-2 cells phenotypically, functionally, and…”
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Disruption of Cyclin D3 Blocks Proliferation of Normal B-1a Cells, but Loss of Cyclin D3 Is Compensated by Cyclin D2 in Cyclin D3-Deficient Mice by Mataraza, Jennifer M, Tumang, Joseph R, Gumina, Maria R, Gurdak, Sean M, Rothstein, Thomas L, Chiles, Thomas C

“…Peritoneal B-1a cells differ from splenic B-2 cells in the molecular mechanisms that control G(0)-S progression. In contrast to B-2 cells, cyclin D2 is…”
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c-Rel Is Required for the Protection of B Cells from Antigen Receptor-Mediated, But Not Fas-Mediated, Apoptosis by Owyang, Alexander M, Tumang, Joseph R, Schram, Brian R, Hsia, Constance Y, Behrens, Timothy W, Rothstein, Thomas L, Liou, Hsiou-Chi

“…The NF-kappaB/Rel transcription factor family has been shown to protect many cell types from apoptotic signals. However, it is not known whether NF-kappaB is…”
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Immunoglobulin kappa enhancers are differentially regulated at the level of chromatin structure by Nikolajczyk, Barbara S., Sardi, Sylvia H., Tumang, Joseph R., Ganley-Leal, Lisa M.

“…The κ intronic and the κ3′ enhancers synergize to regulate recombination and transcription of the Igκ locus. Although these enhancers have overlapping…”
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Characteristic features of B cells in murine cervical lymph nodes by Geun Yeo, Seung, Tumang, Joseph R., Rothstein, Thomas L.

“…Conclusion. B cells in cervical lymph nodes correspond to typical conventional B cells (B-2). Objective. The special status of cervical lymph nodes in relation…”
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